Search Results - "Ishikawa, Tokiro"

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step by Ninagawa, Satoshi, Okada, Tetsuya, Sumitomo, Yoshiki, Kamiya, Yukiko, Kato, Koichi, Horimoto, Satoshi, Ishikawa, Tokiro, Takeda, Shunichi, Sakuma, Tetsushi, Yamamoto, Takashi, Mori, Kazutoshi

“…Glycoproteins misfolded in the endoplasmic reticulum (ER) are subjected to ER-associated glycoprotein degradation (gpERAD) in which Htm1-mediated mannose…”
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Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF6 by Koba, Hibiki, Jin, Shengyu, Imada, Nanami, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Sakuma, Tetsushi, Yamamoto, Takashi, Mori, Kazutoshi

“…ATF6α is an endoplasmic reticulum (ER)-embedded transcription factor which is rapidly activated by ER stress, and a major regulator of ER chaperone levels in…”
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EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD by George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Saito, Taiki, Ishikawa, Tokiro, Sakuma, Tetsushi, Yamamoto, Takashi, Imami, Koshi, Ishihama, Yasushi, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi

“…Sequential mannose trimming of N-glycan (Man GlcNAc -> Man GlcNAc -> Man GlcNAc ) facilitates endoplasmic reticulum-associated degradation of misfolded…”
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A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b by Saito, Shunsuke, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Mori, Kazutoshi

“…A causal relationship between endoplasmic reticulum (ER) stress and the development of neurodegenerative diseases remains controversial. Here, we focused on…”
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Proteomic analysis of fatty liver induced by starvation of medaka fish larvae by Ikeda, Tomoyo, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Ono, Masaya, Mori, Kazutoshi

“…When medaka fish (Oryzias latipes) larvae are grown in the absence of exogenous nutrition, the liver becomes dark and positive to Oil Red O staining from 7…”
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Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish by Jin, Byungseok, Ishikawa, Tokiro, Taniguchi, Mai, Ninagawa, Satoshi, Okada, Tetsuya, Kagaya, Shigehide, Mori, Kazutoshi

“…Three types of transmembrane protein, IRE1α/IRE1β, PERK, and ATF6α/ATF6β, are expressed ubiquitously in vertebrates as transducers of the unfolded protein…”
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Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD by George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Furukawa, Jun-ichi, Hashii, Noritaka, Ishii-Watabe, Akiko, Deng, Ying, Matsushita, Kazutoshi, Ishikawa, Tokiro, Mamahit, Yugoviandi P, Maki, Yuta, Kajihara, Yasuhiro, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi

“…Sequential mannose trimming of N -glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates…”
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Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway by Ninagawa, Satoshi, Okada, Tetsuya, Sumitomo, Yoshiki, Horimoto, Satoshi, Sugimoto, Takehiro, Ishikawa, Tokiro, Takeda, Shunichi, Yamamoto, Takashi, Suzuki, Tadashi, Kamiya, Yukiko, Kato, Koichi, Mori, Kazutoshi

“…Glycoproteins and non-glycoproteins possessing unfolded/misfolded parts in their luminal regions are cleared from the endoplasmic reticulum (ER) by…”
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A Collection of Transgenic Medaka Strains for Efficient Site-Directed Transgenesis Mediated by phiC31 Integrase by Ishikawa, Tokiro, Ansai, Satoshi, Kinoshita, Masato, Mori, Kazutoshi

“…Genetic analysis is facilitated by the efficient production of transgenic strains expressing a DNA of interest as a single copy at a designated chromosomal…”
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SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation by Sugimoto, Takehiro, Ninagawa, Satoshi, Yamano, Shimpei, Ishikawa, Tokiro, Okada, Tetsuya, Takeda, Shunichi, Mori, Kazutoshi

“…Accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). The ATF6 pathway is one of the…”
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Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes by Ninagawa, Satoshi, Tada, Seiichiro, Okumura, Masaki, Inoguchi, Kenta, Kinoshita, Misaki, Kanemura, Shingo, Imami, Koshi, Umezawa, Hajime, Ishikawa, Tokiro, Mackin, Robert B, Torii, Seiji, Ishihama, Yasushi, Inaba, Kenji, Anazawa, Takayuki, Nagamine, Takahiko, Mori, Kazutoshi

“…Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been…”
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Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish by Ishikawa, Tokiro, Kashima, Makoto, Nagano, Atsushi J, Ishikawa-Fujiwara, Tomoko, Kamei, Yasuhiro, Todo, Takeshi, Mori, Kazutoshi

“…When activated by the accumulation of unfolded proteins in the endoplasmic reticulum, metazoan IRE1, the most evolutionarily conserved unfolded protein…”
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Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish by Ishikawa, Tokiro, Taniguchi, Yoshihito, Okada, Tetsuya, Takeda, Shunichi, Mori, Kazutoshi

“…The accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). The ER stress signal is sensed and…”
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Sexually dimorphic dynamics of the microtubule network in medaka (Oryzias latipes) germ cells by Kikuchi, Mariko, Yoshimoto, Miyo, Ishikawa, Tokiro, Kanda, Yuto, Mori, Kazutoshi, Nishimura, Toshiya, Tanaka, Minoru

“…Gametogenesis is the process through which germ cells differentiate into sexually dimorphic gametes, eggs and sperm. In the teleost fish medaka (Oryzias…”
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Proteomic Analysis of Fatty Liver Induced by Starvation of Medaka Fish Larvae by Ikeda, Tomoyo, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Ono, Masaya, Mori, Kazutoshi

“…When medaka fish (Oryzias latipes) larvae are grown in the absence of exogenous nutrition, the liver becomes dark and positive to Oil Red O staining from 7…”
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Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice by Jin, Shengyu, Jin, Byungseok, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Koyasu, Sho, Harada, Hiroshi, Mori, Kazutoshi

“…To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1, PERK, and ATF6 arms, to maintain the…”
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UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner by Ishikawa, Tokiro, Toyama, Takuya, Nakamura, Yuki, Tamada, Kentaro, Shimizu, Hitomi, Ninagawa, Satoshi, Okada, Tetsuya, Kamei, Yasuhiro, Ishikawa-Fujiwara, Tomoko, Todo, Takeshi, Aoyama, Eriko, Takigawa, Masaharu, Harada, Akihiro, Mori, Kazutoshi

“…The unfolded protein response (UPR) handles unfolded/misfolded proteins accumulated in the endoplasmic reticulum (ER). However, it is unclear how vertebrates…”
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ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish by Ishikawa, Tokiro, Okada, Tetsuya, Ishikawa-Fujiwara, Tomoko, Todo, Takeshi, Kamei, Yasuhiro, Shigenobu, Shuji, Tanaka, Minoru, Saito, Taro L, Yoshimura, Jun, Morishita, Shinichi, Toyoda, Atsushi, Sakaki, Yoshiyuki, Taniguchi, Yoshihito, Takeda, Shunichi, Mori, Kazutoshi

“…ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to…”
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Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response using Medaka Fish by Jin, Byungseok, Ishikawa, Tokiro, Taniguchi, Mai, Ninagawa, Satoshi, Okada, Tetsuya, Kagaya, Shigehide, Mori, Kazutoshi

“…Three types of transmembrane protein, IRE1α/IRE1β, PERK, and ATF6α/ATF6β, are expressed ubiquitously in vertebrates as transducers of the unfolded protein…”
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Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish by Jin, Byungseok, Ishikawa, Tokiro, Kashima, Makoto, Komura, Rei, Hirata, Hiromi, Okada, Tetsuya, Mori, Kazutoshi

“…The unfolded protein response is triggered in vertebrates by ubiquitously expressed IRE1α/β (although IRE1β is gut-specific in mice), PERK, and ATF6α/β,…”
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