Search Results - "Ishikawa, Kin'ya"

Spinocerebellar ataxia type 31 (SCA31) by Ishikawa, Kinya

“…Spinocerebellar ataxia type 31 (SCA31) is one of the most common forms of autosomal-dominant cerebellar ataxia in Japan. SCA31 has a strong founder effect,…”
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Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31) by Ishikawa, Kinya, Nagai, Yoshitaka

“…Spinocerebellar ataxia type 31 (SCA31) is one of the autosomal-dominant neurodegenerative disorders that shows progressive cerebellar ataxia as a cardinal…”
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Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model by Shibata, Tomonori, Nagano, Konami, Ueyama, Morio, Ninomiya, Kensuke, Hirose, Tetsuro, Nagai, Yoshitaka, Ishikawa, Kinya, Kawai, Gota, Nakatani, Kazuhiko

“…Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine…”
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Tandem internal models execute motor learning in the cerebellum by Honda, Takeru, Nagao, Soichi, Hashimoto, Yuji, Ishikawa, Kinya, Yokota, Takanori, Mizusawa, Hidehiro, Ito, Masao

“…In performing skillful movement, humans use predictions from internal models formed by repetition learning. However, the computational organization of internal…”
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Gait disorders induced by photothrombotic cerebellar stroke in mice by Inoue, Keisuke, Asaka, Meiko, Lee, Sachiko, Ishikawa, Kinya, Yanagihara, Dai

“…Patients with cerebellar stroke display relatively mild ataxic gaits. These motor deficits often improve dramatically; however, the neural mechanisms of this…”
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Insight Into Spinocerebellar Ataxia Type 31 (SCA31) From Drosophila Model by Ishiguro, Taro, Nagai, Yoshitaka, Ishikawa, Kinya

“…Spinocerebellar ataxia type 31 (SCA31) is a progressive neurodegenerative disease characterized by degeneration of Purkinje cells in the cerebellum. Its…”
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Cryptogenic New-onset Refractory Status Epilepticus with Hyperintensity of T1-weighted Magnetic Resonance Imaging in the Bilateral Basal Ganglia: An Autopsy Report by Takahashi, Sunao, Ono, Daisuke, Shintaku, Hiroshi, Oyama, Jun, Nishida, Yoichiro, Ishikawa, Kinya, Yokota, Takanori

“…We present a 76-year-old man with cryptogenic new-onset refractory status epilepticus (C-NORSE) with an initial abnormal signal in the nucleus accumbens and a…”
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Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 by Ishiguro, Taro, Sato, Nozomu, Ueyama, Morio, Fujikake, Nobuhiro, Sellier, Chantal, Kanegami, Akemi, Tokuda, Eiichi, Zamiri, Bita, Gall-Duncan, Terence, Mirceta, Mila, Furukawa, Yoshiaki, Yokota, Takanori, Wada, Keiji, Taylor, J. Paul, Pearson, Christopher E., Charlet-Berguerand, Nicolas, Mizusawa, Hidehiro, Nagai, Yoshitaka, Ishikawa, Kinya

“…Microsatellite expansion disorders are pathologically characterized by RNA foci formation and repeat-associated non-AUG (RAN) translation. However, their…”
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Spinocerebellar ataxia type 31: A clinical and radiological literature review by Saucier, Jacob, Al-Qadi, Mohammad, Amor, Mouna Ben, Ishikawa, Kinya, Chamard-Witkowski, Ludivine

“…Spinocerebellar ataxia type 31 (SCA31) is an autosomal dominant disease, classified amongst pure cerebellar ataxias (ADCA type 3). While SCA31 is the third…”
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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72 -linked ALS/FTD by Fujino, Yuzo, Ueyama, Morio, Ishiguro, Taro, Ozawa, Daisaku, Ito, Hayato, Sugiki, Toshihiko, Murata, Asako, Ishiguro, Akira, Gendron, Tania, Mori, Kohji, Tokuda, Eiichi, Taminato, Tomoya, Konno, Takuya, Koyama, Akihide, Kawabe, Yuya, Takeuchi, Toshihide, Furukawa, Yoshiaki, Fujiwara, Toshimichi, Ikeda, Manabu, Mizuno, Toshiki, Mochizuki, Hideki, Mizusawa, Hidehiro, Wada, Keiji, Ishikawa, Kinya, Onodera, Osamu, Nakatani, Kazuhiko, Petrucelli, Leonard, Taguchi, Hideki, Nagai, Yoshitaka

“…Abnormal expansions of GGGGCC repeat sequence in the noncoding region of the gene is the most common cause of familial amyotrophic lateral sclerosis and…”
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Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies by Zeniya, Satoshi, Sanjo, Nobuo, Kuwahara, Hiroya, Ishikawa, Kinya, Higashi, Miwa, Matsunaga, Akiko, Yoneda, Makoto, Mizusawa, Hidehiro, Yokota, Takanori

“…We herein report a 61-year-old woman who was genetically diagnosed with spinocerebellar ataxia type 31 whose symptoms were modified by anti-amino terminal of…”
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A commentary on confirmation and refinement of an autosomal dominant congenital motor nystagmus locus in chromosome 1q31.3-q32.1 by Ishikawa, Kinya

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Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model by Aikawa, Tomonori, Mogushi, Kaoru, Iijima-Tsutsui, Kumiko, Ishikawa, Kinya, Sakurai, Miyano, Tanaka, Hiroshi, Mizusawa, Hidehiro, Watase, Kei

“…Spinocerebellar ataxia type 6 (SCA6) is dominantly inherited neurodegenerative disease, caused by an expansion of CAG repeat encoding a polyglutamine (PolyQ)…”
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Uncovering the Localization and Function of a Novel Read-Through Transcript ' TOMM40-APOE ' by Chang, Shichen, Torii, Satoru, Inamo, Jun, Ishikawa, Kinya, Kochi, Yuta, Shimizu, Shigeomi

“…Recent advancements in genome analysis technology have revealed the presence of read-through transcripts in which transcription continues by skipping the polyA…”
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Impaired Adaptive Motor Learning Is Correlated With Cerebellar Hemispheric Gray Matter Atrophy in Spinocerebellar Ataxia Patients: A Voxel-Based Morphometry Study by Bando, Kyota, Honda, Takeru, Ishikawa, Kinya, Takahashi, Yuji, Mizusawa, Hidehiro, Hanakawa, Takashi

“…To evaluate the degree to which recently proposed parameters measured via a prism adaptation task are correlated with changes in cerebellar structure,…”
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Quantitative evaluation of human cerebellum-dependent motor learning through prism adaptation of hand-reaching movement by Hashimoto, Yuji, Honda, Takeru, Matsumura, Ken, Nakao, Makoto, Soga, Kazumasa, Katano, Kazuhiko, Yokota, Takanori, Mizusawa, Hidehiro, Nagao, Soichi, Ishikawa, Kinya

“…The cerebellum plays important roles in motor coordination and learning. However, motor learning has not been quantitatively evaluated clinically. It thus…”
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Comorbid argyrophilic grain disease in an 87-year-old male with spinocerebellar ataxia type 31 with dementia: a case report by Toru, Shuta, Ishida, Shoko, Uchihara, Toshiki, Hirokawa, Katsuiku, Kitagawa, Masanobu, Ishikawa, Kinya

“…Spinocerebellar ataxia type 31 (SCA31) is not usually associated with dementia, and autopsy in a patient with both conditions is very rare. An 87-year-old male…”
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Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42 by Hashiguchi, Shunta, Doi, Hiroshi, Kunii, Misako, Nakamura, Yukihiro, Shimuta, Misa, Suzuki, Etsuko, Koyano, Shigeru, Okubo, Masaki, Kishida, Hitaru, Shiina, Masaaki, Ogata, Kazuhiro, Hirashima, Fumiko, Inoue, Yukichi, Kubota, Shun, Hayashi, Noriko, Nakamura, Haruko, Takahashi, Keita, Katsumoto, Atsuko, Tada, Mikiko, Tanaka, Kenichi, Sasaoka, Toshikuni, Miyatake, Satoko, Miyake, Noriko, Saitsu, Hirotomo, Sato, Nozomu, Ozaki, Kokoro, Ohta, Kiyobumi, Yokota, Takanori, Mizusawa, Hidehiro, Mitsui, Jun, Ishiura, Hiroyuki, Yoshimura, Jun, Morishita, Shinichi, Tsuji, Shoji, Takeuchi, Hideyuki, Ishikawa, Kinya, Matsumoto, Naomichi, Ishikawa, Taro, Tanaka, Fumiaki

“…Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes…”
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A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging by Higashi, Miwa, Ozaki, Kokoro, Hattori, Takaaki, Ishii, Takashi, Soga, Kazumasa, Sato, Nozomu, Tomita, Makoto, Mizusawa, Hidehiro, Ishikawa, Kinya, Yokota, Takanori

“…Cerebellar ataxias (CAs) are heterogeneous conditions often require differential diagnosis. This study aimed to establish a diagnostic decision tree for…”
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Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial by Katsuno, Masahisa, MD, Banno, Haruhiko, MD, Suzuki, Keisuke, MD, Takeuchi, Yu, MD, Kawashima, Motoshi, MD, Yabe, Ichiro, MD, Sasaki, Hidenao, Prof, Aoki, Masashi, MD, Morita, Mitsuya, MD, Nakano, Imaharu, Prof, Kanai, Kazuaki, MD, Ito, Shoichi, MD, Ishikawa, Kinya, MD, Mizusawa, Hidehiro, Prof, Yamamoto, Tomotaka, MD, Tsuji, Shoji, Prof, Hasegawa, Kazuko, MD, Shimohata, Takayoshi, MD, Nishizawa, Masatoyo, Prof, Miyajima, Hiroaki, MD, Kanda, Fumio, Prof, Watanabe, Yasuhiro, MD, Nakashima, Kenji, Prof, Tsujino, Akira, MD, Yamashita, Taro, MD, Uchino, Makoto, Prof, Fujimoto, Yasushi, MD, Tanaka, Fumiaki, MD, Sobue, Gen, Prof

“…Summary Background Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen…”
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