Search Results - "Ishikawa, Hiroki"

JunB regulates homeostasis and suppressive functions of effector regulatory T cells by Koizumi, Shin-ichi, Sasaki, Daiki, Hsieh, Tsung-Han, Taira, Naoyuki, Arakaki, Nana, Yamasaki, Shinichi, Wang, Ke, Sarkar, Shukla, Shirahata, Hiroki, Miyagi, Mio, Ishikawa, Hiroki

“…Foxp3-expressing CD4 + regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor…”
Get full text

One-step syntheses of diaza-dioxa-fenestranes via the sequential (3 + 2) cycloadditions of linear precursors and their structural analyses by Fuse, Shinichiro, Ishikawa, Hiroki, Kitamura, Hiroshi, Masui, Hisashi, Takahashi, Takashi

“…Fenestranes, in which four rings share one carbon atom, have garnered much attention because of their flattened quaternary carbon centers. In addition, the…”
Get full text

JunB is essential for IL-23-dependent pathogenicity of Th17 cells by Hasan, Zafrul, Koizumi, Shin-ichi, Sasaki, Daiki, Yamada, Hayato, Arakaki, Nana, Fujihara, Yoshitaka, Okitsu, Shiho, Shirahata, Hiroki, Ishikawa, Hiroki

“…CD4 + T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (T H 17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity…”
Get full text

Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells by Koizumi, Shin-Ichi, Ishikawa, Hiroki

“…Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance…”
Get full text

Chiral Symmetry Breaking of Monoacylated Anhydroerythritols and meso‐1,2‐Diols through Crystallization‐Induced Deracemization by Sanada, Kazutaka, Washio, Aoi, Ishikawa, Hiroki, Yoshida, Yasushi, Mino, Takashi, Sakamoto, Masami

“…We developed a chiral symmetry breaking method for monoacylated meso diols. The X‐ray crystal structure analysis of monoacylated 1,4‐anhydroerythritols, meso…”
Get full text

Effect of Ethanol Vapor Inhalation Treatment on Lethal Respiratory Viral Infection With Influenza A by Tamai, Miho, Taba, Seita, Mise, Takeshi, Yamashita, Masao, Ishikawa, Hiroki, Shintake, Tsumoru

“…Abstract Ethanol (EtOH) effectively inactivates enveloped viruses in vitro, including influenza and severe acute respiratory syndrome coronavirus 2. Inhaled…”
Get full text

The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression by Ito-Kureha, Taku, Miyao, Takahisa, Nishijima, Saori, Suzuki, Toru, Koizumi, Shin-ichi, Villar-Briones, Alejandro, Takahashi, Akinori, Akiyama, Nobuko, Morita, Masahiro, Naguro, Isao, Ishikawa, Hiroki, Ichijo, Hidenori, Akiyama, Taishin, Yamamoto, Tadashi

“…A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are…”
Get full text

Normal menstrual flow volume range and its characteristics measured from sanitary napkins in Japanese women: Discrepancy between measured and subjective menstrual flow volume by Atsuko, Shiota, Hiromi, Teraoka, Hiroki, Ishikawa

“…Aim The 2018 International Federation of Gynecology and Obstetrics abnormal uterine bleeding System‐1 defines menstrual flow volume on a 3‐point scale based on…”
Get full text

HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages by Nagashima, Ryuichi, Ishikawa, Hiroki, Kuno, Yoshihiro, Kohda, Chikara, Iyoda, Masayuki

“…Hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors are therapeutic agents for renal anemia that work through HIF2-mediated upregulation of…”
Get full text

Essential role of hydride ion in ruthenium-based ammonia synthesis catalysts by Kitano, Masaaki, Inoue, Yasunori, Ishikawa, Hiroki, Yamagata, Kyosuke, Nakao, Takuya, Tada, Tomofumi, Matsuishi, Satoru, Yokoyama, Toshiharu, Hara, Michikazu, Hosono, Hideo

“…The efficient reduction of atmospheric nitrogen to ammonia under low pressure and temperature conditions has been a challenge in meeting the rapidly increasing…”
Get full text

STING pathway and regulation of innate immune signaling in response to DNA pathogens by Ishikawa, Hiroki, Barber, Glen N

“…The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR),…”
Get full text

Efficient and Stable Ammonia Synthesis by Self-Organized Flat Ru Nanoparticles on Calcium Amide by Inoue, Yasunori, Kitano, Masaaki, Kishida, Kazuhisa, Abe, Hitoshi, Niwa, Yasuhiro, Sasase, Masato, Fujita, Yusuke, Ishikawa, Hiroki, Yokoyama, Toshiharu, Hara, Michikazu, Hosono, Hideo

“…Efficient and stable catalysts for ammonia synthesis under mild conditions are required to meet the strong demand for NH3 as an important precursor chemical…”
Get full text

Cardiac interaction between mother and infant: enhancement of heart rate variability by Suga, Ayami, Uraguchi, Maki, Tange, Akiko, Ishikawa, Hiroki, Ohira, Hideki

“…The vagal activity of infants is represented by heart rate variability (HRV) and associated with both growth and socioemotional development. The enhancement of…”
Get full text

JunB Is Critical for Survival of T Helper Cells by Hsieh, Tsunghan, Sasaki, Daiki, Taira, Naoyuki, Chien, Hsiaochiao, Sarkar, Shukla, Seto, Yu, Miyagi, Mio, Ishikawa, Hiroki

“…Clonal expansion and differentiation of various T helper subsets, such as Th1, Th2, and Th17 cells, depend on a complex of transcription factors, IRF4 and a…”
Get full text

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity by Chen, Huihui, Sun, Hui, You, Fuping, Sun, Wenxiang, Zhou, Xiang, Chen, Lu, Yang, Jing, Wang, Yutao, Tang, Hong, Guan, Yukun, Xia, Weiwei, Gu, Jun, Ishikawa, Hiroki, Gutman, Delia, Barber, Glen, Qin, Zhihai, Jiang, Zhengfan

“…STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune…”
Get full text

Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols by Ishikawa, Hiroki, Touge, Taichiro, Kuriyama, Wataru, Kida, Michio, Matsumura, Kazuhiko

“…A highly efficient synthesis of sugar alcohols was achieved by selective hydrogenation with a homogeneous catalyst. Ru-MACHO-BH, the PNHP-ruthenium catalyst,…”
Get full text

Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung by Ishikawa, Hiroki, Fukui, Toshie, Ino, Satoshi, Sasaki, Hiraku, Awano, Naoki, Kohda, Chikara, Tanaka, Kazuo

“…Abstract The immunological mechanisms of secondary bacterial infection followed by influenza virus infection were examined. When mice were intranasally…”
Get full text

Anti-inflammatory Effect of the Water-Soluble Portion of Porcine Placental Extract in Lipopolysaccharide-Stimulated RAW264.7 Murine Macrophage Cells by Tebakari, Masahiko, Daigo, Yuki, Ishikawa, Hiroki, Nakamura, Mika, Kawashima, Junichi, Takano, Fumihide

“…Porcine placental extract (PPE) is used as a nonprescription drug for analeptics and in health foods and cosmetics in Japan, Korea and China. It was reported…”
Get full text

Impact of Relative Dose Intensity of Early-phase Lenvatinib Treatment on Therapeutic Response in Hepatocellular Carcinoma by Takahashi, Aya, Moriguchi, Michihisa, Seko, Yuya, Ishikawa, Hiroki, Yo, Takaharu, Kimura, Hiroyuki, Fujii, Hideki, Shima, Toshihide, Mitsumoto, Yasuhide, Ishiba, Hiroshi, Takashima, Hidetaka, Nagao, Yasuyuki, Jo, Masayasu, Arai, Masahiro, Hara, Tasuku, Okajima, Akira, Muramatsu, Akira, Morita, Atsuhiro, Yoshinami, Naomi, Nakajima, Tomoki, Mitsuyoshi, Hironori, Umemura, Atsushi, Nishikawa, Taichiro, Yamaguchi, Kanji, Itoh, Yoshito

“…Factors associated with response to lenvatinib have not been clarified in patients with hepatocellular carcinoma (HCC). This study retrospectively analyzed 50…”
Get full text

Improvement Effects of Trehangelin A on High-Fat Diet Causing Metabolic Clinical Conditions by Ishikawa, Hiroki, Ino, Satoshi, Nakashima, Takuji, Matsuo, Hirotaka, Takahashi, Yōko, Kohda, Chikara, Ōmura, Satoshi, Tanaka, Kazuo

“…The purpose of this study is to determine whether or not trehangelin A (THG-A) is effective in treating the metabolic clinical condition caused by a high-fat…”
Get full text