Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH-4, a monoclonal antibody specific for the eccrine gland

The histogenesis of apocrine and eccrine neoplasms has always interested dermatopathologists. In addition, the histologic differential diagnosis of eccrine carcinoma from metastatic adenocarcinoma is of practical importance. We describe a novel monoclonal antibody IKH‐4 which stains the eccrine secr...

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Bibliographic Details
Published in:	Journal of cutaneous pathology Vol. 25; no. 2; pp. 100 - 105
Main Authors:	Ishihara, Masabiko, Mehregan, Darius R., Hashimoto, Ken, Yotsumoto, Shinichi, Toi, Yoichiro, Pietruk, Teresa, Mehregan, Amir H., Mehregan, David A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-02-1998 Blackwell
Subjects:	Adenocarcinoma - chemistry Adenocarcinoma - pathology Adenocarcinoma - secondary Animals Antibodies, Monoclonal - analysis Antibodies, Monoclonal - immunology Apocrine Glands - chemistry Apocrine Glands - pathology Biological and medical sciences Dermatology Eccrine Glands - chemistry Eccrine Glands - immunology Eccrine Glands - pathology Immunohistochemistry Medical sciences Mice Mice, Inbred BALB C Skin - chemistry Skin - pathology Skin Neoplasms - chemistry Skin Neoplasms - pathology Staining and Labeling - methods Sweat Gland Neoplasms - chemistry Sweat Gland Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions Adenocarcinoma Human Immunohistochemistry Pathology Skin disease Apocrine gland Tumor Monoclonal antibody Metastasis Differential diagnostic Eccrine gland
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Summary:	The histogenesis of apocrine and eccrine neoplasms has always interested dermatopathologists. In addition, the histologic differential diagnosis of eccrine carcinoma from metastatic adenocarcinoma is of practical importance. We describe a novel monoclonal antibody IKH‐4 which stains the eccrine secretory coil, but not the apocrine secretory segment. Positive staining was observed in eccrine hidradenoma, eccrine poroma, eccrine spiradenoma, papillary eccrine adenoma, eccrine hidrocystoma, syringoma, eccrine carcinoma, and in 1 case of syringocystadenoma papilliferum. Negative staining was observed in apocrine adenocarcinoma, hidradenoma papilliferum, erosive adenomatosis of the nipple, and primary and metastatic adenocarcinomas. IKH‐4 antibody was useful in differentiating eccrine from apocrine neoplasms and in differentiating eccrine carcinoma from metastatic adenocarcinomas.
Bibliography:	ArticleID:CUP100 ark:/67375/WNG-1KK83FQ0-9 istex:9194A47B3EEEAABE2D682BA46F5905862459BA52 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0303-6987 1600-0560
DOI:	10.1111/j.1600-0560.1998.tb01697.x