Search Results - "Ishida, Keishi"

Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota by Shao, Yongqi, Chen, Bosheng, Sun, Chao, Ishida, Keishi, Hertweck, Christian, Boland, Wilhelm

“…Insects develop efficient antimicrobial strategies to flourish in a bacterial world. It has long been proposed that native gut microbiota is an important…”
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Evaluation of the Estrogenic Action Potential of Royal Jelly by Genomic Signaling Pathway in Vitro and in Vivo by Ishida, Keishi, Matsumaru, Daisuke, Shimizu, Shinya, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Royal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals…”
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Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases by Peng, Huiyun, Ishida, Keishi, Sugimoto, Yuki, Jenke-Kodama, Holger, Hertweck, Christian

“…Polyketides produced by modular type I polyketide synthases (PKSs) play eminent roles in the development of medicines. Yet, the production of structural…”
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Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium by Pidot, Sacha, Ishida, Keishi, Cyrulies, Michael, Hertweck, Christian

“…Genome mining of the strictly anaerobic bacterium Clostridium beijerinckii, an industrial producer of solvents, revealed the presence of several cryptic gene…”
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The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions by Zilliges, Yvonne, Kehr, Jan-Christoph, Meissner, Sven, Ishida, Keishi, Mikkat, Stefan, Hagemann, Martin, Kaplan, Aaron, Börner, Thomas, Dittmann, Elke

“…Microcystins are cyanobacterial toxins that represent a serious threat to drinking water and recreational lakes worldwide. Here, we show that microcystin…”
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Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons by Ishida, Keishi, Kotake, Yaichiro, Sanoh, Seigo, Ohta, Shigeru

“…Lead is a persistent environmental pollutant and exposure to high environmental levels causes various deleterious toxicities, especially to the central nervous…”
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Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum by Lincke, Thorger, Behnken, Swantje, Ishida, Keishi, Roth, Martin, Hertweck, Christian

“…Choose sulfur in an oxygen‐free world: Closthioamide (1) was isolated from the anaerobe Clostridium cellulolyticum (see SEM image) after the induction of its…”
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Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A by Ishida, Keishi, Furukawa, Motoshi, Kunitani, Masataka, Yamagiwa, Rai, Hiromori, Youhei, Matsumaru, Daisuke, Hu, Jianying, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Low doses of bisphenol A (BPA), a typical endocrine-disrupting chemical (EDC), have been reported to exhibit estrogenic action in animals; however, the effects…”
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Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist by Ma, Haojia, Ishida, Keishi, Xu, Chenke, Takahashi, Kyosuke, Li, Yu, Zhang, Chenhao, Kang, Qiyue, Jia, Yingting, Hu, Wenxin, Matsumaru, Daisuke, Nakanishi, Tsuyoshi, Hu, Jianying

“…Although concerns have been raised about the adverse effects of triphenyl phosphate (TPhP) on female fertility, its risk to ovarian functioning remains…”
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Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons by Ishida, Keishi, Takeda, Kazuki, Takehara, Yuki, Takabayashi, Tomoki, Miyara, Masatsugu, Sanoh, Seigo, Kawai, Hidehiko, Ohta, Shigeru, Kotake, Yaichiro

“…Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular…”
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Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor by Trottmann, Felix, Ishida, Keishi, Franke, Jakob, Stanišić, Aleksa, Ishida‐Ito, Mie, Kries, Hajo, Pohnert, Georg, Hertweck, Christian

“…Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as…”
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Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination by Niehs, Sarah P., Kumpfmüller, Jana, Dose, Benjamin, Little, Rory F., Ishida, Keishi, Flórez, Laura V., Kaltenpoth, Martin, Hertweck, Christian

“…Genome mining of one of the protective symbionts (Burkholderia gladioli) of the invasive beetle Lagria villosa revealed a cryptic gene cluster that codes for…”
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Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity by Ishida, Keishi, Tatsumi, Kanoko, Minamigawa, Yoshiki, Mori, Kazuma, Matsumaru, Daisuke, Nagase, Hisamitsu, Kanda, Yasunari, Takuma, Kazuhiro, Nakanishi, Tsuyoshi

“…[Display omitted] Current in vivo developmental neurotoxicity (DNT) tests are not performed routinely for chemical risk assessment because they are time and…”
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Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant by Ishida, Keishi, Lincke, Thorger, Behnken, Swantje, Hertweck, Christian

“…Genetic manipulation of the LuxR-type quorum sensing regulator system in Burkholderia thailandensis caused a significant change in the metabolic profile: it…”
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Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom-Forming Cyanobacteria by Ziemert, Nadine, Ishida, Keishi, Liaimer, Anton, Hertweck, Christian, Dittmann, Elke

“…Decoding biosynthesis: Cage‐like depsipeptides have been investigated by a combination of genetic and chemical analyses. Heterologous expression and MALDI‐PSD…”
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Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway by Litomska, Agnieszka, Ishida, Keishi, Dunbar, Kyle L., Boettger, Marco, Coyne, Sébastien, Hertweck, Christian

“…6‐Thioguanine (6TG) is a DNA‐targeting therapeutic used in the treatment of various cancers. While 6TG was rationally designed as a proof of concept for…”
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Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis by Shiraishi, Erina, Ishida, Keishi, Matsumaru, Daisuke, Ido, Akiko, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Propolis is a resinous mixture produced by bees from their secretions and plant material, so its composition varies depending on its botanical origin. Propolis…”
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Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory by Shabuer, Gulimila, Ishida, Keishi, Pidot, Sacha J., Roth, Martin, Dahse, Hans-Martin, Hertweck, Christian

“…Around 25% of vegetable food is lost worldwide because of infectious plant diseases, including microbe-induced decay of harvested crops. In wet seasons and…”
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Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium by Krumbholz, Julia, Ishida, Keishi, Baunach, Martin, Teikari, Jonna E., Rose, Magdalena M., Sasso, Severin, Hertweck, Christian, Dittmann, Elke

“…Genomes of cyanobacteria feature a variety of cryptic biosynthetic pathways for complex natural products, but the peculiarities limiting the discovery and…”
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Exploiting the mosaic structure of trans -acyltransferase polyketide synthases for natural product discovery and pathway dissection by Hochmuth, Thomas, Hertweck, Christian, Taudien, Stefan, Ishida, Keishi, Jenke-Kodama, Holger, Dittmann, Elke, Platzer, Matthias, Nguyen, TuAnh, Gurgui, Cristian, Piel, Jörn

“…Modular polyketide synthases (PKSs) are giant bacterial enzymes that synthesize many polyketides of therapeutic value. In contrast to PKSs that provide…”
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