Search Results - "Ishaya, Kristin"

Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas by Broz, Marina T., Ko, Emily Y., Ishaya, Kristin, Xiao, Jinfen, De Simone, Marco, Hoi, Xen Ping, Piras, Roberta, Gala, Basia, Tessaro, Fernando H. G., Karlstaedt, Anja, Orsulic, Sandra, Lund, Amanda W., Chan, Keith Syson, Guarnerio, Jlenia

“…T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors…”
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1432 Cancer-associated fibroblasts metabolic targeting overcomes T-cell exclusion and chemoresistance by Broz, Marina, Ko, Emily, Ishaya, Kristin, Xiao, Jinfen, DeSimone, Marco, Xen Ping Hoi, Piras, Roberta, Gala, Basia, Fernando HG Tessaro, Orsulic, Sandra, Balzer, Bonnie, Chan, Keith Syson, Guarnerio, Jlenia

“…BackgroundRecent advances in T cell-based immunotherapies have shown promise in controlling tumor growth, but their effectiveness is limited in immune-excluded…”
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Abstract 1364: Profiling tumor microenvironment for therapeutic intervention to soft-tissue sarcomas by Xiao, Jin-Fen, Broz, Marina, Piras, Roberta, Ishaya, Kristin, Ko, Emily, Guarnerio, Jlenia

“…Abstract Soft-tissue sarcomas (STS) are mesenchymal tumors having remarkably diverse histological features. Genomic studies reported that STS have low…”
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Abstract 1255: Glucose dependent CD73+ CAFs enforce a tumor metabolic barrier that promotes T cell exclusion by Broz, Marina, Ko, Emily, Xiao, Jinfen, DeSimone, Marco, Piras, Roberta, Ishaya, Kristin, Hoi, Xen Ping, Guarnerio, Jlenia

“…Abstract Trafficking of T lymphocytes from the lymph nodes to the tumor microenvironment is a critical process of the tumor immunity cycle to elicit cytotoxic…”
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