Search Results - "Ishak Gabra, Mari B."

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 by Yang, Ying, Ishak Gabra, Mari B., Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Li, Haiqing, Milman, Neta, Liu, Juan, Reid, Michael A., Locasale, Jason W., Gil, Ziv, Kong, Mei

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which…”
Get full text

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth by Ishak Gabra, Mari B., Yang, Ying, Li, Haiqing, Senapati, Parijat, Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Zhang, Lishi, Doan, Linda T., Xu, Xiangdong, Schones, Dustin E., Fruman, David A., Kong, Mei

“…Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells…”
Get full text

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake by Lowman, Xazmin H., Hanse, Eric A., Yang, Ying, Ishak Gabra, Mari B., Tran, Thai Q., Li, Haiqing, Kong, Mei

“…Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of…”
Get full text

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes by Tran, Thai Q, Ishak Gabra, Mari B, Lowman, Xazmin H, Yang, Ying, Reid, Michael A, Pan, Min, O'Connor, Timothy R, Kong, Mei

“…Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this…”
Get full text

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing by Davis, Ryan T., Blake, Kerrigan, Ma, Dennis, Gabra, Mari B. Ishak, Hernandez, Grace A., Phung, Anh T., Yang, Ying, Maurer, Dustin, Lefebvre, Austin E. Y. T., Alshetaiwi, Hamad, Xiao, Zhengtao, Liu, Juan, Locasale, Jason W., Digman, Michelle A., Mjolsness, Eric, Kong, Mei, Werb, Zena, Lawson, Devon A.

“…Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here, we…”
Get full text

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer by Tran, Thai Q, Hanse, Eric A, Habowski, Amber N, Li, Haiqing, Ishak Gabra, Mari B, Yang, Ying, Lowman, Xazmin H, Ooi, Amelia M, Liao, Shu Y, Edwards, Robert A, Waterman, Marian L, Kong, Mei

“…Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental…”
Get full text

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3 by Reid, Michael A, Lowman, Xazmin H, Pan, Min, Tran, Thai Q, Warmoes, Marc O, Ishak Gabra, Mari B, Yang, Ying, Locasale, Jason W, Kong, Mei

“…Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how…”
Get full text

The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte by Hanse, Eric A, Pan, Min, Liu, Wenzhu, Yang, Ying, Ishak Gabra, Mari B, Tran, Thai Q, Lowman, Xazmin H, Ruiz, Bryan, Wang, Qiong A, Kong, Mei

“…Adipose tissue plays a major role in maintaining organismal metabolic equilibrium. Control over the fate decision from mesenchymal stem cells (MSCs) to…”
Get full text

IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation by Ishak Gabra, Mari B., Yang, Ying, Lowman, Xazmin H., Reid, Michael A., Tran, Thai Q., Kong, Mei

“…One of the hallmarks of cancer is the ability to reprogram cellular metabolism to increase the uptake of necessary nutrients such as glucose and glutamine…”
Get full text

Adaptations to Glutamine Deprivation in Cancer and Its Use as a Dietary Supplement in Cancer Therapeutics by Ishak Gabra, Mari B

“…Tumors reprogram pathways of nutrient acquisition and metabolism to meet their bioenergetic needs and fast proliferation. Glutamine, a non-essential amino…”
Get full text

Bcl-2 inhibitor scaffolds that are preorganized along an axis of chirality; the effect of atropisomerism on protein binding by Ishak Gabra, Mari B

“…Atropisomerism is a form of chirality that arises from hindered rotation around a bond resulting in rotational isomers that are non-superimposable mirror image…”
Get full text