Search Results - "Isha Jain"

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism by Jain, Isha H., Calvo, Sarah E., Markhard, Andrew L., Skinner, Owen S., To, Tsz-Leung, Ast, Tslil, Mootha, Vamsi K.

“…Human cells are able to sense and adapt to variations in oxygen levels. Historically, much research in this field has focused on hypoxia-inducible factor (HIF)…”
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Turning the Oxygen Dial: Balancing the Highs and Lows by Baik, Alan H., Jain, Isha H.

“…Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the human body and is required for several hundred diverse biochemical…”
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Hypoxia as a therapy for mitochondrial disease by Jain, Isha H., Zazzeron, Luca, Goli, Rahul, Alexa, Kristen, Schatzman-Bone, Stephanie, Dhillon, Harveen, Goldberger, Olga, Peng, Jun, Shalem, Ophir, Sanjana, Neville E., Zhang, Feng, Goessling, Wolfram, Zapol, Warren M., Mootha, Vamsi K.

“…Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We…”
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Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome by Ferrari, Michele, Jain, Isha H., Goldberger, Olga, Rezoagli, Emanuele, Thoonen, Robrecht, Cheng, Kai-Hung, Sosnovik, David E., Scherrer-Crosbie, Marielle, Mootha, Vamsi K., Zapol, Warren M.

“…The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of…”
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Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells by Shivaraju, Manjunatha, Chitta, Udbhav K, Grange, Robert M H, Jain, Isha H, Capen, Diane, Liao, Lan, Xu, Jianming, Ichinose, Fumito, Zapol, Warren M, Mootha, Vamsi K, Rajagopal, Jayaraj

“…Neuroendocrine (NE) cells are epithelial cells that possess many of the characteristics of neurons, including the presence of secretory vesicles and the…”
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Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation by Jain, Isha H, Zazzeron, Luca, Goldberger, Olga, Marutani, Eizo, Wojtkiewicz, Gregory R, Ast, Tslil, Wang, Hong, Schleifer, Grigorij, Stepanova, Anna, Brepoels, Kathleen, Schoonjans, Luc, Carmeliet, Peter, Galkin, Alexander, Ichinose, Fumito, Zapol, Warren M, Mootha, Vamsi K

“…Leigh syndrome is a devastating mitochondrial disease for which there are no proven therapies. We previously showed that breathing chronic, continuous hypoxia…”
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A high resolution map of a cyanobacterial transcriptome by Vijayan, Vikram, Jain, Isha H, O'Shea, Erin K

“…Previous molecular and mechanistic studies have identified several principles of prokaryotic transcription, but less is known about the global transcriptional…”
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Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism by Midha, Ayush D., Zhou, Yuyin, Queliconi, Bruno B., Barrios, Alec M., Haribowo, Augustinus G., Chew, Brandon T.L., Fong, Cyril O.Y., Blecha, Joseph E., VanBrocklin, Henry, Seo, Youngho, Jain, Isha H.

“…Oxygen deprivation can be detrimental. However, chronic hypoxia is also associated with decreased incidence of metabolic syndrome and cardiovascular disease in…”
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Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria by Jain, Isha H, Vijayan, Vikram, O’Shea, Erin K

“…Many cyanobacteria have been shown to harbor multiple chromosome copies per cell, yet little is known about the organization, replication, and segregation of…”
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Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes by Baik, Alan H., Haribowo, Augustinus G., Chen, Xuewen, Queliconi, Bruno B., Barrios, Alec M., Garg, Ankur, Maishan, Mazharul, Campos, Alexandre R., Matthay, Michael A., Jain, Isha H.

“…Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms remain largely unknown. Here, we systematically investigate the…”
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Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer by Ravichandran, Mirunalini, Hu, Jingjie, Cai, Charles, Ward, Nathan P, Venida, Anthony, Foakes, Callum, Kuljanin, Miljan, Yang, Annan, Hennessey, Connor J, Yang, Yang, Desousa, Brandon R, Rademaker, Gilles, Staes, Annelot A L, Cakir, Zeynep, Jain, Isha H, Aguirre, Andrew J, Mancias, Joseph D, Shen, Yin, DeNicola, Gina M, Perera, Rushika M

“…The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma (PDA) cells to pharmacologic inhibition of RAS-MAPK signaling are largely…”
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Oral Manifestations of Tuberculosis: Step towards Early Diagnosis by Jain, Pankaj, Jain, Isha

“…Tuberculosis, as known universally, is a chronic infectious disease that can affect any part of the body including mouth. It usually affects the lungs, TB…”
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Evaluation of the effect of bimaxillary, mandibular setback, and advancement surgeries on the pharyngeal airway space and positions of the hyoid bone, soft palate, and tongue by Jain, Isha, Pradhan, Tejashri, Sethia, Aarti

“…Introduction: This study aims to assess the postoperative changes in the pharyngeal airway space and the positions of the hyoid bone, soft palate, and tongue…”
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Comparison of hemodynamic effects of intravenous labetalol plus intravenous fentanyl and intravenous fentanyl alone for attenuating reflex responses to laryngoscopy and intubation: A prospective randomized controlled trial by Jain, Isha, Satyendra Singh Yadav, Shakti Singhal, Jaykumar Kolewar, Preeti Goyal

“…Background: Laryngoscopy is an essential part of endotracheal intubation. Direct laryngoscopy and tracheal intubation are a noxious stimulation that causes…”
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Comparative evaluation of antimicrobial efficacy of three different formulations of mouth rinses with multi-herbal mouth rinse by Jain, Isha, Jain, Pankaj

“…Context: In response to the propagation of various anti-Streptococcus preventive agents, the discovery of newer and more efficient agents which are more…”
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Current advancements and future prospects of COVID-19 vaccines and therapeutics: a narrative review by Sanyaolu, Adekunle, Okorie, Chuku, Marinkovic, Aleksandra, Prakash, Stephanie, Williams, Martina, Haider, Nafees, Mangat, Jasmine, Hosein, Zaheeda, Balendra, Vyshnavy, Abbasi, Abu Fahad, Desai, Priyank, Jain, Isha, Utulor, Stephen, Abioye, Amos

“…Coronavirus disease 2019 (COVID-19) has made a global impact on the daily lives of humanity, devastating health systems, and cataclysmically affecting the…”
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Comparative Evaluation of Antibacterial Efficacy of Six Indian Plant Extracts against Streptococcus Mutans by Jain, Isha, Jain, Pankaj, Bisht, Dakshina, Sharma, Alosha, Srivastava, Binita, Gupta, Nidhi

“…To assess the antimicrobial efficacy of six plant extracts of Indian origin often used as traditional medicine against standard strains of Streptococcus…”
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In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response by Chen, Xuewen, Haribowo, Augustinus G, Baik, Alan H, Fossati, Andrea, Stevenson, Erica, Chen, Yiwen R, Reyes, Nabora S, Peng, Tien, Matthay, Michael A, Traglia, Michela, Pico, Alexander R, Jarosz, Daniel F, Buchwalter, Abigail, Ghaemmaghami, Sina, Swaney, Danielle L, Jain, Isha H

“…Oxygen deprivation and excess are both toxic. Thus, the body's ability to adapt to varying oxygen tensions is critical for survival. While the hypoxia…”
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Reactogenicity to COVID-19 vaccination in the United States of America by Sanyaolu, Adekunle, Marinkovic, Aleksandra, Prakash, Stephanie, Desai, Priyank, Haider, Nafees, Abbasi, Abu Fahad, Mehraban, Nasima, Jain, Isha, Ekeh, Amarachi, Shazley, Omar, Okorie, Chuku, Orish, Verner N

“…In the United States, Pfizer-BioNTech, Moderna, and Janssen's coronavirus disease 2019 (COVID-19) vaccines have been granted Emergency Use Authorization (EUA)…”
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Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration by Hoptak-Solga, Angela D., Nielsen, Sarah, Jain, Isha, Thummel, Ryan, Hyde, David R., Iovine, M. Kathryn

“…In zebrafish, mutations in the gap junction gene connexin43 lead to short bony fin ray segments that give rise to the short fin phenotype. The sofb123 mutant…”
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