Search Results - "Isfort, Robert J."

Red-COLA1: a human fibroblast reporter cell line for type I collagen transcription by Wong, Hui Hui, Seet, Sze Hwee, Bascom, Charles C., Isfort, Robert J., Bard, Frederic

“…Type I collagen is a key protein of most connective tissue and its up-regulation is required for wound healing but is also involved in fibrosis. Control of…”
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Newborn infant skin gene expression: Remarkable differences versus adults by Visscher, Marty O, Hu, Ping, Carr, Andrew N, Bascom, Charles C, Isfort, Robert J, Creswell, Kellen, Adams, Rachel, Tiesman, Jay P, Lammers, Karen, Narendran, Vivek

“…At birth, human infants are poised to survive in harsh, hostile conditions. An understanding of the state of newborn skin development and maturation is key to…”
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Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women by Abadi, Arkan, Glover, Elisa I, Isfort, Robert J, Raha, Sandeep, Safdar, Adeel, Yasuda, Nobuo, Kaczor, Jan J, Melov, Simon, Hubbard, Alan, Qu, Xiaoyan, Phillips, Stuart M, Tarnopolsky, Mark

“…Advancements in animal models and cell culture techniques have been invaluable in the elucidation of the molecular mechanisms that regulate muscle atrophy…”
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Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment by Sherrill, Joseph D, Finlay, Deborah, Binder, Robert L, Robinson, Michael K, Wei, Xingtao, Tiesman, Jay P, Flagler, Michael J, Zhao, Wenzhu, Miller, Catherine, Loftus, Jean M, Kimball, Alexa B, Bascom, Charles C, Isfort, Robert J

“…Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate…”
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Sex differences in global mRNA content of human skeletal muscle by Maher, Amy C, Fu, Minghua H, Isfort, Robert J, Varbanov, Alex R, Qu, Xiaoyan A, Tarnopolsky, Mark A

“…Women oxidize more fat as compared to men during endurance exercise and several groups have shown that the mRNA content of selected genes related to fat…”
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Mouse hair cycle expression dynamics modeled as coupled mesenchymal and epithelial oscillators by Tasseff, Ryan, Bheda-Malge, Anjali, DiColandrea, Teresa, Bascom, Charles C, Isfort, Robert J, Gelinas, Richard

“…The hair cycle is a dynamic process where follicles repeatedly move through phases of growth, retraction, and relative quiescence. This process is an example…”
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Quantitative proteogenomic profiling of epidermal barrier formation in vitro by Winget, Jason M, Watts, Julian D, Hoopmann, Michael R, DiColandrea, Teresa, Robinson, Michael K, Huggins, Tom, Bascom, Charles C, Isfort, Robert J, Moritz, Robert L

“…Highlights • Proteomics and transcriptomics were performed for a model of epidermal development. • 3661 proteins were identified across three developmentally…”
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Aging-Associated Changes in the Adult Human Skin Microbiome and the Host Factors that Affect Skin Microbiome Composition by Howard, Brian, Bascom, Charles C., Hu, Ping, Binder, Robert L., Fadayel, Gina, Huggins, Tom G., Jarrold, Bradley B., Osborne, Rosemarie, Rocchetta, Heather L., Swift, Dionne, Tiesman, Jay P., Song, Yuli, Wang, Yu, Wehmeyer, Kenneth, Kimball, Alexa B., Isfort, Robert J.

“…Understanding the changes in the skin microbiome and their relationship to host skin factors during aging remains largely unknown. To better understand this…”
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Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor by Hinkle, Richard T., Hodge, Karen M.B., Cody, David B., Sheldon, Russell J., Kobilka, Brian K., Isfort, Robert J.

“…Analyses were performed to evaluate the roles of the β1‐ and β2‐adrenergic receptors in the skeletal muscle hypertrophy and anti‐atrophy response to the…”
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Transcriptional profiling of epidermal barrier formation in vitro by Bachelor, Michael, Binder, Robert L, Cambron, R. Thomas, Kaczvinsky, Joseph R, Spruell, Russell, Wehmeyer, Kenneth R, Reilman, Raymond, Adams, Rachel, Tiesman, Jay P, Wang, Yu, Bascom, Charles C, Isfort, Robert J, DiColandrea, Teresa

“…Abstract Background Barrier function is integral to the health of epithelial tissues. Currently, there is a broad need to develop and improve our knowledge…”
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Autophagy promotes cell survival by maintaining NAD levels by Kataura, Tetsushi, Sedlackova, Lucia, Otten, Elsje G., Kumari, Ruchika, Shapira, David, Scialo, Filippo, Stefanatos, Rhoda, Ishikawa, Kei-ichi, Kelly, George, Seranova, Elena, Sun, Congxin, Maetzel, Dorothea, Kenneth, Niall, Trushin, Sergey, Zhang, Tong, Trushina, Eugenia, Bascom, Charles C., Tasseff, Ryan, Isfort, Robert J., Oblong, John E., Miwa, Satomi, Lazarou, Michael, Jaenisch, Rudolf, Imoto, Masaya, Saiki, Shinji, Papamichos-Chronakis, Manolis, Manjithaya, Ravi, Maddocks, Oliver D.K., Sanz, Alberto, Sarkar, Sovan, Korolchuk, Viktor I.

“…Autophagy is an essential catabolic process that promotes the clearance of surplus or damaged intracellular components. Loss of autophagy in age-related human…”
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Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells by Sadofsky, Laura R, Sreekrishna, Koti T, Lin, Yakang, Schinaman, Renee, Gorka, Kate, Mantri, Yogita, Haught, John Christian, Huggins, Thomas G, Isfort, Robert J, Bascom, Charles C, Morice, Alyn H

“…Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1…”
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Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions by Reichart, Deborah L, Hinkle, Richard T, Lefever, Frank R, Dolan, Elizabeth T, Dietrich, Jeffrey A, Sibley, David R, Isfort, Robert J

“…Control of skeletal muscle mass and force production is a complex physiological process involving numerous regulatory systems. Agents that increase skeletal…”
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Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy by Hinkle, Richard T., Dolan, Elizabeth, Cody, David B., Bauer, Mary Beth, Isfort, Robert J.

“…Several GTP‐binding protein (G‐protein)–coupled receptors that signal through Gαs (GTP‐binding protein α stimulatory) and the cyclic adenosine monophosphate…”
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Tonic repression of collagen I by the bradykinin receptor 2 in skin fibroblasts by Wong, Hui Hui, Seet, Sze Hwee, Bascom, Charles C, Isfort, Robert J, Bard, Frederic A

“…•Genetic analysis by RNAi reveals that collagen I is under tonic repression in fibroblasts.•Bradykinin receptor 2 (BDKRB2), a G-protein couple receptor repress…”
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Effects of a CRF2R agonist and exercise on mdx and wildtype skeletal muscle by Hall, Julie E., Kaczor, Jan J., Hettinga, Bart P., Isfort, Robert J., Tarnopolsky, Mark A.

“…Corticotrophin‐releasing factor 2 receptor (CRF2R) agonists prevent muscle atrophy due to immobilization, denervation, and corticosteroid‐induced muscle…”
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Quantitative Proteomic Analysis of Stratum Corneum Dysfunction in Adult Chronic Atopic Dermatitis by Winget, Jason M., Finlay, Deborah, Mills, Kevin J., Huggins, Tom, Bascom, Charles, Isfort, Robert J., Moritz, Robert L.

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Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age by Kimball, Alexa B., Alora-Palli, Maria B., Tamura, Makio, Mullins, Lisa A., Soh, Chieko, Binder, Robert L., Houston, Neil A., Conley, Emily D., Tung, Joyce Y., Annunziata, Nikki E., Bascom, Charles C., Isfort, Robert J., Jarrold, Bradley B., Kainkaryam, Raghu, Rocchetta, Heather L., Swift, Dionne D., Tiesman, Jay P., Toyama, Kazumi, Xu, Jun, Yan, Xianghong, Osborne, Rosemarie

“…Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. We evaluated molecular changes occurring in…”
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PyCoTools: a Python toolbox for COPASI by Welsh, Ciaran M, Fullard, Nicola, Proctor, Carole J, Martinez-Guimera, Alvaro, Isfort, Robert J, Bascom, Charles C, Tasseff, Ryan, Przyborski, Stefan A, Shanley, Daryl P

“…Abstract Motivation COPASI is an open source software package for constructing, simulating and analyzing dynamic models of biochemical networks. COPASI is…”
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Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy by Wong, Hui Hui, Seet, Sze Hwee, Maier, Michael, Gurel, Ayse, Traspas, Ricardo Moreno, Lee, Cheryl, Zhang, Shan, Talim, Beril, Loh, Abigail Y.T., Chia, Crystal Y., Teoh, Tze Shin, Sng, Danielle, Rensvold, Jarred, Unal, Sule, Shishkova, Evgenia, Cepni, Ece, Nathan, Fatima M., Sirota, Fernanda L., Liang, Chao, Yarali, Nese, Simsek-Kiper, Pelin O., Mitani, Tadahiro, Ceylaner, Serdar, Arman-Bilir, Ozlem, Mbarek, Hamdi, Gumruk, Fatma, Efthymiou, Stephanie, Uğurlu Çi̇men, Deniz, Georgiadou, Danai, Sotiropoulou, Kortessa, Houlden, Henry, Paul, Franziska, Pehlivan, Davut, Lainé, Candice, Chai, Guoliang, Ali, Nur Ain, Choo, Siew Chin, Keng, Soh Sok, Boisson, Bertrand, Yılmaz, Elanur, Xue, Shifeng, Coon, Joshua J., Ly, Thanh Thao Nguyen, Gilani, Naser, Hasbini, Dana, Kayserili, Hulya, Zaki, Maha S., Isfort, Robert J., Ordonez, Natalia, Tripolszki, Kornelia, Bauer, Peter, Rezaei, Nima, Seyedpour, Simin, Khotaei, Ghamar Taj, Bascom, Charles C., Maroofian, Reza, Chaabouni, Myriam, Alsubhi, Afaf, Eyaid, Wafaa, Işıkay, Sedat, Gleeson, Joseph G., Lupski, James R., Casanova, Jean-Laurent, Pagliarini, David J., Akarsu, Nurten A., Maurer-Stroh, Sebastian, Cetinkaya, Arda, Bertoli-Avella, Aida, Mathuru, Ajay S., Ho, Lena, Bard, Frederic A., Reversade, Bruno

“…Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a…”
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