Search Results - "Iserloh, Ulrich"

Enantioselective Synthesis of the Oxadecalin Core of Phomactin A via a Highly Stereoselective Diels−Alder Reaction by Chemler, Sherry R, Iserloh, Ulrich, Danishefsky, Samuel J

“…Phomactin A (1) is a selective antagonist of platelet activating factor (PAF). Herein, we report our progress toward the construction of the oxadecalin core of…”
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Radical Cyclizations of Acylgermane Oxime Ethers and Hydrazones:  Direct Routes to Cyclic Hydrazones and Oximes by Iserloh, Ulrich, Curran, Dennis P

“…Efficient syntheses of ω-halo-, phenylseleno-, and vinylacylgermane hydrazones and oxime ethers have been developed, and the radical cyclizations of these…”
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Enantioselective conjugate radical addition reactions mediated by chiral Lewis acid complexes of ( R, R)-4,6-dibenzofurandiyl-2,2′-bis(4-phenyloxazoline) (DBFOX/Ph) by Iserloh, Ulrich, Curran, Dennis P, Kanemasa, Shuji

“…A high-yielding synthesis (50% overall yield) of tridentate bisoxazoline ligand ( R, R)-4,6-dibenzofurandiyl-2,2′-bis(4-phenyloxazoline) (DBFOX/Ph) was…”
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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease by Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W

“…Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein…”
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Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity by Wang, Zhi-Guang, Zhang, Xufang, Visser, Michael, Live, David, Zatorski, Andrzej, Iserloh, Ulrich, Lloyd, Kenneth O., Danishefsky, Samuel J.

“…Blood typing with the ABO classification is based on cell‐surface glycoproteins. In a significant step toward the synthesis of these compounds, the laboratory…”
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Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor by Cumming, Jared N., Smith, Elizabeth M., Wang, Lingyan, Misiaszek, Jeffrey, Durkin, James, Pan, Jianping, Iserloh, Ulrich, Wu, Yusheng, Zhu, Zhaoning, Strickland, Corey, Voigt, Johannes, Chen, Xia, Kennedy, Matthew E., Kuvelkar, Reshma, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Czarniecki, Michael F., Greenlee, William J., McKittrick, Brian A., Parker, Eric M., Stamford, Andrew W.

“…From an initial lead 1, a structure-based design approach led to identification of a novel, high-affinity iminohydantoin BACE1 inhibitor that lowers…”
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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors by McKittrick, Brian A., Caldwell, John P., Bara, Thomas, Boykow, George, Chintala, Madhu, Clader, John, Czarniecki, Michael, Courneya, Brandy, Duffy, Ruth, Fleming, Linda, Giessert, Rachel, Greenlee, William J., Heap, Charles, Hong, Liwu, Huang, Ying, Iserloh, Ulrich, Josien, Hubert, Khan, Tanweer, Korfmacher, Walter, Liang, Xian, Mazzola, Robert, Mitra, Soumya, Moore, Kristina, Orth, Peter, Rajagopalan, Murali, Roy, Sudipta, Sakwa, Samuel, Strickland, Corey, Vaccaro, Henry, Voigt, Johannes, Wang, Hongwu, Wong, Jesse, Zhang, Rumin, Zych, Andrew

“…The development of renin inhibitors with favorable oral pharmacokinetic profiles has been a longstanding challenge for the pharmaceutical industry. As part of…”
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Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity by Wang, Zhi-Guang, Zhang, Xufang, Visser, Michael, Live, David, Zatorski, Andrzej, Iserloh, Ulrich, Lloyd, Kenneth O., Danishefsky, Samuel J.

“…Die AB0‐Blutgruppen‐Bestimmung beruht auf Glycoproteinen auf der Zelloberfläche. Ein bedeutender Schritt in Richtung der Synthese dieser Verbindungen ist die…”
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A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant by Wang, Zhi-Guang, Warren, J. David, Dudkin, Vadim Y., Zhang, Xufang, Iserloh, Ulrich, Visser, Michael, Eckhardt, Matthias, Seeberger, Peter H., Danishefsky, Samuel J.

“…The total synthesis of an H-type blood group determinant in a model biological setting is described. The construct is comprised of a high mannose core…”
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P3‐272: Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease by Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Cumming, Jared, Iserloh, Ulrich, McKittrick, Brian, Pan, Janping, Smith, Elizabeth, Sun, Zhong-Yue, Stamford, Andrew, Zhu, Zhaoning, Beyer, Brian, Strickland, Corey, Voigt, Johannes, Wang, Yu-Sen, Wyss, Daniel, Parker, Eric M.

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Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease by Kennedy, Matthew E, Chen, Xia, Kuvelkar, Reshma, Cumming, Jared, Iserloh, Ulrich, McKittrick, Brian, Pan, Janping, Smith, Elizabeth, Sun, Zhong-Yue, Stamford, Andrew, Zhu, Zhaoning, Beyer, Brian, Strickland, Corey, Voigt, Johannes, Wang, Yu-Sen, Wyss, Daniel, Parker, Eric M

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Reducing oligosaccharides via glycal assembly: on the remarkable stability of anomeric hydroxyl groups to global deprotection with sodium in liquid ammonia by Iserloh, Ulrich, Dudkin, Vadim, Wang, Zhi-Guang, Danishefsky, Samuel J

“…Several partially benzylated 1-hydroxy sugars were rapidly deprotected by sodium/liquid ammonia. The terminal hemiketal linkage of the substrates remained…”
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Free radical chemistry: New synthetic methods and studies towards penitrem D by Iserloh, Ulrich

“…A new route to triphenylacylgermanes and related oxime ethers and hydrazones has been implemented. The reaction of Ph3GeCu with 5-bromovaleryl chloride gave…”
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A Strategy for Probing the Autonomy of Cross-Domain Stereochemical Communication in Glycoconjugates by Live, David H, Wang, Zhi-Guang, Iserloh, Ulrich, Danishefsky, Samuel J

“…Glycoproteins contain carbohydrate and peptide sectors. As a model for studying whether there exists stereochemical “communication” between the two domains, we…”
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Design and development of BACE-1 inhibitors by Cumming, Jared N, Iserloh, Ulrich, Kennedy, Matthew E

“…In early 1999, beta-amyloid cleaving enzyme-1 (BACE-1) was identified as the protease responsible for the critical first step in the processing of beta-amyloid…”
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Web Site: A Free and Fast Chemical Reaction Search by Iserloh, Ulrich

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Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity This work was supported by the National Institutes of Health (Grant nos.: HL-25848 and CA-28824 (to S.J.D.), and CA-710506 (to K.O.L.)). Postdoctoral fellowship support is gratefully acknowledged by Z.-G.W. (US Army breast cancer grant no.: DAMD17-97-1-7119) and M.V. (NIH grant no.: CA-62948-04). We gratefully acknowledge Dr. George Sukenick of the Sl by Wang, Zhi-Guang, Zhang, Xufang, Visser, Michael, Live, David, Zatorski, Andrzej, Iserloh, Ulrich, Lloyd, Kenneth O., Danishefsky, Samuel J.

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Web Site: Frei zugängliche, schnelle Suche nach chemischen Reaktionen by Iserloh, Ulrich

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Web Site: Frei zugängliche, schnelle Suche nach chemischen Reaktionen by Iserloh, Ulrich

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