Search Results - "Isbrucker, Richard A"

Pivotal Shigella Vaccine Efficacy Trials-Study Design Considerations from a Shigella Vaccine Trial Design Working Group by Pavlinac, Patricia B, Rogawski McQuade, Elizabeth T, Platts-Mills, James A, Kotloff, Karen L, Deal, Carolyn, Giersing, Birgitte K, Isbrucker, Richard A, Kang, Gagandeep, Ma, Lyou-Fu, MacLennan, Calman A, Patriarca, Peter, Steele, Duncan, Vannice, Kirsten S

“…Vaccine candidates for are approaching phase 3 clinical trials in the target population of young children living in low- and middle-income countries. Key study…”
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Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin by Isbrucker, Richard A., Cummins, Jennifer, Pomponi, Shirley A., Longley, Ross E., Wright, Amy E.

“…Dictyostatin-1 had previously been isolated from a marine sponge of the genus Spongia sp. and described as a cytotoxic agent to murine and human cancer cells,…”
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Early effects of lasonolide a on pancreatic cancer cells by Isbrucker, Richard A, Guzmán, Esther A, Pitts, Tara P, Wright, Amy E

“…Lasonolide A, a novel polyketide-derived macrolide, was previously identified from an extract of the marine sponge Forcepia sp. in an assay for protein kinase…”
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Modified binding assay for improved sensitivity and specificity in the detection of residual pertussis toxin in vaccine preparations by Isbrucker, Richard A, Bliu, Alex, Prior, Fiona

“…Abstract A binding assay was recently published that differentiates between pertussis toxin (PTx) and the pertussis toxoid (PTd) used in acellular pertussis…”
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Five New Discodermolide Analogues from the Marine Sponge Discodermia Species by Gunasekera, Sarath P, Paul, Gopal K, Longley, Ross E, Isbrucker, Richard A, Pomponi, Shirley A

“…Discodermolide (1) and five new discodermolide analogues trivially named 2-epi-discodermolide (2), 2-des-methyldiscodermolide (3),…”
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Semisynthetic Analogues of the Microtubule-Stabilizing Agent Discodermolide:  Preparation and Biological Activity by Gunasekera, Sarath P, Longley, Ross E, Isbrucker, Richard A

“…A series of 12 semisynthetic discodermolide analogues, 2−13, have been prepared using natural (+)-discodermolide (1) and evaluated for in vitro cytotoxicity…”
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Plakolide A, a New γ-Lactone from the Marine Sponge Plakortis sp by Gunasekera, Sarath P, Isbrucker, Richard A, Longley, Ross E, Wright, Amy E, Pomponi, Shirley A, Reed, John K

“…Plakolide A (1), a new α-exomethylene-γ-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS)…”
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Acetylated Analogues of the Microtubule-Stabilizing Agent Discodermolide:  Preparation and Biological Activity by Gunasekera, Sarath P, Longley, Ross E, Isbrucker, Richard A

“…A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured…”
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Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity by ISBRUCKER, Richard A, GUNASEKERA, Sarath P, LONGLEY, Ross E

“…Discodermolide, a natural product from the marine sponge Discodermia dissoluta, has been previously described as an antimitotic agent with microtubule…”
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Platelet-Derived Growth Factor and Pentoxifylline Modulation of Collagen Synthesis in Myofibroblasts by Isbrucker, Richard A., Peterson, Theresa C.

“…Fibroblast proliferation and extracellular matrix accumulation are two major events occurring in fibrosis. Hepatic stellate cells are the major…”
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Fibroproliferation in liver disease: role of monocyte factors by Peterson, T C, Isbrucker, R A

“…Fibroproliferation was measured as the uptake of [3H]thymidine into fibroblasts. Human fibroblasts were incubated with 200 microliters monocyte-conditioned…”
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In vitro effect of platelet-derived growth factor on fibroproliferation and effect of cytokine antagonists by Peterson, T C, Isbrucker, R A, Hooper, M L

“…Platelet-derived growth factor (PDGF) stimulates fibroblast proliferation and increases collagen synthesis. Fibroproliferation, as assessed by tritiated…”
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