Search Results - "Isakson, Peter C"

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  1. 1

    Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents by Kurumbail, Ravi G, Stevens, Anna M, Gierse, James K, McDonald, Joseph J, Stegeman, Roderick A, Pak, Jina Y, Gildehaus, Daniel, iyashiro, Julie M, Penning, Thomas D, Seibert, Karen, Isakson, Peter C, Stallings, William C

    Published in Nature (London) (26-12-1996)
    “…Prostaglandins and glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of…”
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  2. 2

    Effects of Celecoxib, a Novel Cyclooxygenase-2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial by Leese, Philip T., Hubbard, Richard C., Karim, Aziz, Isakson, Peter C., Yu, Shawn S., Geis, G. Steven

    Published in Journal of clinical pharmacology (01-02-2000)
    “…Conventional nonsteroidal anti‐inflammatory drugs (NSAIDs) nonspecifically inhibit cyclooxygenase‐1 (COX‐1), an enzyme critical to normal platelet function,…”
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  3. 3

    Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity by Gierse, James K, Zhang, Yan, Hood, William F, Walker, Mark C, Trigg, Jennifer S, Maziasz, Timothy J, Koboldt, Carol M, Muhammad, Jerry L, Zweifel, Ben S, Masferrer, Jaime L, Isakson, Peter C, Seibert, Karen

    “…The discovery of a second isoform of cyclooxygenase (COX) led to the search for compounds that could selectively inhibit COX-2 in humans while sparing…”
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  4. 4

    Pharmacology of celecoxib in rat brain after kainate administration by Ciceri, Paola, Zhang, Yan, Shaffer, Alex F, Leahy, Kathleen M, Woerner, Mark B, Smith, Walter G, Seibert, Karen, Isakson, Peter C

    “…Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its…”
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  5. 5

    Characterization of celecoxib and valdecoxib binding to cyclooxygenase by Hood, William F, Gierse, James K, Isakson, Peter C, Kiefer, James R, Kurumbail, Ravi G, Seibert, Karen, Monahan, Joseph B

    Published in Molecular pharmacology (01-04-2003)
    “…Two compounds (celecoxib and valdecoxib) from the diarylheterocycle class of cyclooxygenase inhibitors were radiolabeled and used to characterize their binding…”
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    Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release by DIRIG, D. M, KONIN, G. P, ISAKSON, P. C, YAKSH, T. L

    Published in European journal of pharmacology (23-07-1997)
    “…Spinally delivery of the non-specific cyclooxygenase inhibitor, S(+)-ibuprofen, reduces the second phase of the formalin test and the evoked release of…”
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    Celecoxib versus diclofenac in long-term management of rheumatoid arthritis : randomised double-blind comparison by EMERY, P, ZEIDLER, H, KVIEN, T. K, GUSLANDI, M, NAUDIN, R, STEAD, H, VERBURG, K. M, ISAKSON, P. C, HUBBARD, R. C, GEIS, G. S

    Published in The Lancet (British edition) (18-12-1999)
    “…Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX), which leads to suppression of COX-1-mediated production of…”
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  10. 10

    Pharmacological Analysis of Cyclooxygenase-1 in Inflammation by Smith, Christopher J., Zhang, Yan, Koboldt, Carol M., Muhammad, Jerry, Zweifel, Ben S., Shaffer, Alex, Talley, John J., Masferrer, Jaime L., Seibert, Karen, Isakson, Peter C.

    “…The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs…”
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  11. 11

    Effects of celecoxib and naproxen on renal function in the elderly by Whelton, A, Schulman, G, Wallemark, C, Drower, E J, Isakson, P C, Verburg, K M, Geis, G S

    Published in Archives of internal medicine (1960) (22-05-2000)
    “…To compare the effects of celecoxib, a cyclooxygenase 2-specific inhibitor, with the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in…”
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  12. 12
  13. 13

    Kinetic basis for selective inhibition of cyclo-oxygenases by Gierse, J K, Koboldt, C M, Walker, M C, Seibert, K, Isakson, P C

    Published in Biochemical journal (01-05-1999)
    “…Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostaglandins by cyclo-oxygenases (COX). The discovery of a second COX isoform (COX-2)…”
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    Cyclooxygenase-2 Inhibition Prevents Delayed Death of CA1 Hippocampal Neurons Following Global Ischemia by Nakayama, Masaki, Uchimura, Koichi, Zhu, Raymond Li, Nagayama, Tetsuya, Rose, Marie E., Stetler, R. Anne, Isakson, Peter C., Chen, Jun, Graham, Steven H.

    “…The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important…”
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  16. 16

    Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production by Zhang, Y, Shaffer, A, Portanova, J, Seibert, K, Isakson, P C

    “…PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. In the present study, we…”
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  17. 17

    Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats by Dirig, D M, Isakson, P C, Yaksh, T L

    “…Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role…”
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  18. 18

    Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic by MASFERRER, J. L, ZWEIFEL, B. S, MANNING, P. T, HAUSER, S. D, LEAHY, K. M, SMITH, W. G, ISAKSON, P. C, SEIBERT, K

    “…We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces…”
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  19. 19

    A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors by Walker, M C, Kurumbail, R G, Kiefer, J R, Moreland, K T, Koboldt, C M, Isakson, P C, Seibert, K, Gierse, J K

    Published in Biochemical journal (01-08-2001)
    “…Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms,…”
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  20. 20

    1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2 by Khanna, Ish K, Weier, Richard M, Yu, Yi, Collins, Paul W, Miyashiro, Julie M, Koboldt, Carol M, Veenhuizen, Amy W, Currie, Jerry L, Seibert, Karen, Isakson, Peter C

    Published in Journal of medicinal chemistry (23-05-1997)
    “…Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The…”
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