Search Results - "Isakson, Peter C"
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Published in Nature (London) (26-12-1996)“…Prostaglandins and glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of…”
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Effects of Celecoxib, a Novel Cyclooxygenase-2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial
Published in Journal of clinical pharmacology (01-02-2000)“…Conventional nonsteroidal anti‐inflammatory drugs (NSAIDs) nonspecifically inhibit cyclooxygenase‐1 (COX‐1), an enzyme critical to normal platelet function,…”
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3
Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity
Published in The Journal of pharmacology and experimental therapeutics (01-03-2005)“…The discovery of a second isoform of cyclooxygenase (COX) led to the search for compounds that could selectively inhibit COX-2 in humans while sparing…”
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Pharmacology of celecoxib in rat brain after kainate administration
Published in The Journal of pharmacology and experimental therapeutics (01-09-2002)“…Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its…”
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Characterization of celecoxib and valdecoxib binding to cyclooxygenase
Published in Molecular pharmacology (01-04-2003)“…Two compounds (celecoxib and valdecoxib) from the diarylheterocycle class of cyclooxygenase inhibitors were radiolabeled and used to characterize their binding…”
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The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E2 Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1
Published in The Journal of neuroscience (15-08-2001)“…Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective…”
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Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release
Published in European journal of pharmacology (23-07-1997)“…Spinally delivery of the non-specific cyclooxygenase inhibitor, S(+)-ibuprofen, reduces the second phase of the formalin test and the evoked release of…”
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Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis: A Randomized Controlled Trial
Published in JAMA : the journal of the American Medical Association (24-11-1999)“…CONTEXT In vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not COX-1, suggesting that this drug may have anti-inflammatory and…”
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9
Celecoxib versus diclofenac in long-term management of rheumatoid arthritis : randomised double-blind comparison
Published in The Lancet (British edition) (18-12-1999)“…Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX), which leads to suppression of COX-1-mediated production of…”
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Pharmacological Analysis of Cyclooxygenase-1 in Inflammation
Published in Proceedings of the National Academy of Sciences - PNAS (27-10-1998)“…The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs…”
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Effects of celecoxib and naproxen on renal function in the elderly
Published in Archives of internal medicine (1960) (22-05-2000)“…To compare the effects of celecoxib, a cyclooxygenase 2-specific inhibitor, with the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in…”
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1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Published in Journal of medicinal chemistry (01-10-1995)Get full text
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13
Kinetic basis for selective inhibition of cyclo-oxygenases
Published in Biochemical journal (01-05-1999)“…Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostaglandins by cyclo-oxygenases (COX). The discovery of a second COX isoform (COX-2)…”
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Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
Published in Journal of Allergy and Clinical Immunology (01-05-2003)“…Background: Subjects with aspirin-intolerant asthma (AIA) respond with bronchoconstriction and extrapulmonary adverse reactions to conventional nonsteroidal…”
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Cyclooxygenase-2 Inhibition Prevents Delayed Death of CA1 Hippocampal Neurons Following Global Ischemia
Published in Proceedings of the National Academy of Sciences - PNAS (01-09-1998)“…The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important…”
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Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production
Published in The Journal of pharmacology and experimental therapeutics (01-12-1997)“…PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. In the present study, we…”
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Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats
Published in The Journal of pharmacology and experimental therapeutics (01-06-1998)“…Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role…”
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Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic
Published in Proceedings of the National Academy of Sciences - PNAS (12-04-1994)“…We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces…”
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
Published in Biochemical journal (01-08-2001)“…Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms,…”
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1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2
Published in Journal of medicinal chemistry (23-05-1997)“…Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The…”
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