Search Results - "Isakson, Brant"

Differentiating connexin hemichannels and pannexin channels in cellular ATP release by Lohman, Alexander W., Isakson, Brant E.

“…Adenosine triphosphate (ATP) plays a fundamental role in cellular communication, with its extracellular accumulation triggering purinergic signaling cascades…”
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AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus by Liu, Shufeng, DeLalio, Leon J, Isakson, Brant E, Wang, Tony T

“…RATIONALE:The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question about how the virus gets into human…”
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Pharmacology of pannexin channels by Koval, Michael, Schug, Wyatt J., Isakson, Brant E.

“…Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic…”
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Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice by Bisht, Kanchan, Okojie, Kenneth A., Sharma, Kaushik, Lentferink, Dennis H., Sun, Yu-Yo, Chen, Hong-Ru, Uweru, Joseph O., Amancherla, Saipranusha, Calcuttawala, Zainab, Campos-Salazar, Antony Brayan, Corliss, Bruce, Jabbour, Lara, Benderoth, Jordan, Friestad, Bria, Mills, William A., Isakson, Brant E., Tremblay, Marie-Ève, Kuan, Chia-Yi, Eyo, Ukpong B.

“…Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, the extent of their interactions with the vasculature and…”
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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia by Kuhn, Viktoria, Diederich, Lukas, Keller, 4th, T C Stevenson, Kramer, Christian M, Lückstädt, Wiebke, Panknin, Christina, Suvorava, Tatsiana, Isakson, Brant E, Kelm, Malte, Cortese-Krott, Miriam M

“…Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events,…”
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Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension by Brown, Isola A.M, Diederich, Lukas, Good, Miranda E, DeLalio, Leon J, Murphy, Sara A, Cortese-Krott, Miriam M, Hall, Jennifer L, Le, Thu H, Isakson, Brant E

“…Cardiovascular disease is a leading cause of death worldwide and accounts for >17.3 million deaths per year, with an estimated increase in incidence to 23.6…”
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Mechanisms of ATP release and signalling in the blood vessel wall by LOHMAN, Alexander W, BILLAUD, Marie, ISAKSON, Brant E

“…The nucleotide adenosine 5'-triphosphate (ATP) has classically been considered the cell's primary energy currency. Importantly, a novel role for ATP as an…”
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity by Ottolini, Matteo, Hong, Kwangseok, Cope, Eric L., Daneva, Zdravka, DeLalio, Leon J., Sokolowski, Jennifer D., Marziano, Corina, Nguyen, Nhiem Y., Altschmied, Joachim, Haendeler, Judith, Johnstone, Scott R., Kalani, Mohammad Y., Park, Min S., Patel, Rakesh P., Liedtke, Wolfgang, Isakson, Brant E., Sonkusare, Swapnil K.

“…BACKGROUND:Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca signaling in endothelial cells…”
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Bedding as a variable affecting fasting blood glucose and vascular physiology in mice by Sveeggen, Timothy M, Isakson, Brant E, Straub, Adam C, Bagher, Pooneh

“…Rodent husbandry requires careful consideration of environmental factors that may impact colony performance and subsequent physiological studies. Of note,…”
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Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism by Polizio, Ariel H, Marino, Lucila, Min, Kyung-Duk, Yura, Yoshimitsu, Rolauer, Luca, Cochran, Jesse D, Evans, Megan A, Park, Eunbee, Doviak, Heather, Miura-Yura, Emiri, Good, Miranda E, Wolpe, Abigail G, Grandoch, Maria, Isakson, Brant, Walsh, Kenneth

“…Hypertension incidence increases with age and represents one of the most prevalent risk factors for cardiovascular disease. Clonal events in the hematopoietic…”
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Connexins and Pannexins in Vascular Function and Disease by Molica, Filippo, Figueroa, Xavier F, Kwak, Brenda R, Isakson, Brant E, Gibbins, Jonathan M

“…Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and…”
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Guidelines for the measurement of vascular function and structure in isolated arteries and veins by Wenceslau, Camilla F, McCarthy, Cameron G, Earley, Scott, England, Sarah K, Filosa, Jessica A, Goulopoulou, Styliani, Gutterman, David D, Isakson, Brant E, Kanagy, Nancy L, Martinez-Lemus, Luis A, Sonkusare, Swapnil K, Thakore, Pratish, Trask, Aaron J, Watts, Stephanie W, Webb, R Clinton

“…The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the…”
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Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation by Lohman, Alexander W., Leskov, Igor L., Butcher, Joshua T., Johnstone, Scott R., Stokes, Tara A., Begandt, Daniela, DeLalio, Leon J., Best, Angela K., Penuela, Silvia, Leitinger, Norbert, Ravichandran, Kodi S., Stokes, Karen Y., Isakson, Brant E.

“…Inflammatory cell recruitment to local sites of tissue injury and/or infection is controlled by a plethora of signalling processes influencing cell-to-cell…”
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TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates Gq Protein–Coupled Receptor–Induced Vasoconstriction by Hong, Kwangseok, Cope, Eric L, DeLalio, Leon J, Marziano, Corina, Isakson, Brant E, Sonkusare, Swapnil K

“…OBJECTIVE—Several physiological stimuli activate smooth muscle cell (SMC) GqPCRs (Gq protein–coupled receptors) to cause vasoconstriction. As a protective…”
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Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation by Filiberto, Amanda C., Spinosa, Michael D., Elder, Craig T., Su, Gang, Leroy, Victoria, Ladd, Zachary, Lu, Guanyi, Mehaffey, J. Hunter, Salmon, Morgan D., Hawkins, Robert B., Ravichandran, Kodi S., Isakson, Brant E., Upchurch, Gilbert R., Sharma, Ashish K.

“…Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases…”
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Heme metabolism in nonerythroid cells by Dunaway, Luke S., Loeb, Skylar A., Petrillo, Sara, Tolosano, Emanuela, Isakson, Brant E.

“…Heme is an iron-containing prosthetic group necessary for the function of several proteins termed “hemoproteins.” Erythrocytes contain most of the body’s heme…”
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Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure by Leo, Francesca, Suvorava, Tatsiana, Heuser, Sophia K., Li, Junjie, LoBue, Anthea, Barbarino, Frederik, Piragine, Eugenia, Schneckmann, Rebekka, Hutzler, Beate, Good, Miranda E., Fernandez, Bernadette O., Vornholz, Lukas, Rogers, Stephen, Doctor, Allan, Grandoch, Maria, Stegbauer, Johannes, Weitzberg, Eddie, Feelisch, Martin, Lundberg, Jon O., Isakson, Brant E., Kelm, Malte, Cortese-Krott, Miriam M.

“…Current paradigms suggest that nitric oxide (NO) produced by endothelial cells (ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the…”
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Brain endothelial cell TRPA1 channels initiate neurovascular coupling by Thakore, Pratish, Alvarado, Michael G, Ali, Sher, Mughal, Amreen, Pires, Paulo W, Yamasaki, Evan, Pritchard, Harry At, Isakson, Brant E, Tran, Cam Ha T, Earley, Scott

“…Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels…”
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Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis by Ravichandran, Kodi S, Chekeni, Faraaz B, Elliott, Michael R, Sandilos, Joanna K, Walk, Scott F, Kinchen, Jason M, Lazarowski, Eduardo R, Armstrong, Allison J, Penuela, Silvia, Laird, Dale W, Salvesen, Guy S, Isakson, Brant E, Bayliss, Douglas A

“…Apoptotic cells release 'find-me' signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me…”
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