Search Results - "Isaji, Masayuki"

SGLT2 inhibitors: molecular design and potential differences in effect by Isaji, Masayuki

“…The physiological and pathological handling of glucose via sodium–glucose cotransporter-2 (SGLT2) in the kidneys has been evolving, and SGLT2 inhibitors have…”
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Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models by Fujimori, Yoshikazu, Katsuno, Kenji, Nakashima, Ikumi, Ishikawa-Takemura, Yukiko, Fujikura, Hideki, Isaji, Masayuki

“…The low-affinity sodium glucose cotransporter (SGLT2) plays an important role in renal glucose reabsorption and is a remarkable transporter as a molecular…”
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Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level by Katsuno, Kenji, Fujimori, Yoshikazu, Takemura, Yukiko, Hiratochi, Masahiro, Itoh, Fumiaki, Komatsu, Yoshimitsu, Fujikura, Hideki, Isaji, Masayuki

“…The low-affinity sodium glucose cotransporter (SGLT2), which is expressed specifically in the kidney, plays a major role in renal glucose reabsorption in the…”
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Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation by Inoue, Toshihiro, Takemura, Masaaki, Fushimi, Nobuhiko, Fujimori, Yoshikazu, Onozato, Tomoya, Kurooka, Takao, Asari, Tetsuya, Takeda, Hiroo, Kobayashi, Mamoru, Nishibe, Hironori, Isaji, Masayuki

“…Chronic constipation is a highly common functional gastrointestinal disorder that adversely affects patient quality of life. At present, limited therapeutic…”
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KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models by Shibazaki, Toshihide, Tomae, Masaki, Ishikawa-Takemura, Yukiko, Fushimi, Nobuhiko, Itoh, Fumiaki, Yamada, Mitsuhiko, Isaji, Masayuki

“…The high-affinity sodium glucose cotransporter (SGLT1) plays a critical role in glucose absorption from the gastrointestinal tract. We have developed…”
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Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout by Tatani, Kazuya, Hiratochi, Masahiro, Kikuchi, Norihiko, Kuramochi, Yu, Watanabe, Shinjiro, Yamauchi, Yuji, Itoh, Fumiaki, Isaji, Masayuki, Shuto, Satoshi

“…To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary…”
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Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats by Fujimori, Yoshikazu, Katsuno, Kenji, Ojima, Kazuma, Nakashima, Ikumi, Nakano, Shigeru, Ishikawa-Takemura, Yukiko, Kusama, Hiroshi, Isaji, Masayuki

“…The low-affinity sodium glucose cotransporter (SGLT2) is responsible for most of the glucose reabsorption in the kidney and has been highlighted as a novel…”
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Identification of 8‑Aminoadenosine Derivatives as a New Class of Human Concentrative Nucleoside Transporter 2 Inhibitors by Tatani, Kazuya, Hiratochi, Masahiro, Nonaka, Yoshinori, Isaji, Masayuki, Shuto, Satoshi

“…Purine-rich foods have long been suspected as a major cause of hyperuricemia. We hypothesized that inhibition of human concentrative nucleoside transporter 2…”
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Phlorizin Prevents Electrically-Induced Ventricular Tachyarrhythmia during Ischemia in Langendorff-Perfused Guinea-Pig Hearts by Hirose, Masamichi, Shibazaki, Toshihide, Nakada, Tsutomu, Kashihara, Toshihide, Yano, Shiharu, Okamoto, Yoshie, Isaji, Masayuki, Matsushita, Naoko, Taira, Eiichi, Yamada, Mitsuhiko

“…Phlorizin is a type of flavonoids and has a peroxynitrite scavenging effect. This study aimed to elucidate the effects of phlorizin on ischemia-induced…”
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Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin by Oana, Fumiki, Takeda, Hiroo, Hayakawa, Kohichi, Matsuzawa, Akane, Akahane, Satoshi, Isaji, Masayuki, Akahane, Masuo

“…Obese (fa/fa) Zucker rat is a spontaneous genetic obesity model and, by comparison with lean Zucker rat, exhibits hyperphagia, hyperinsulinemia, and…”
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Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo by Isaji, Masayuki, Miyata, Hiroshi, Ajisawa, Yoshiyuki, Takehana, Yasuo, Yoshimura, Nagahisa

“…1 First developed as an antiallergic drug, tranilast inhibits chemical mediator release from mast cells. In the present study, we examine the effects of…”
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Sodium-glucose cotransporter inhibitors for diabetes by Isaji, Masayuki

“…In the search for potential new drug targets for the treatment of diabetes, sodium-glucose cotransporters (SGLTs), in particular SGLT2, have been the subject…”
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Rat model of the hypercalcaemia induced by parathyroid hormone-related protein: characteristics of three bisphosphonates by Komatsu, Yoshimitsu, Imai, Yohsuke, Itoh, Fumiaki, Kojima, Masami, Isaji, Masayuki, Shibata, Nobuo

“…In our preliminary experiment, we found that a constant infusion of a high dose of parathyroid hormone-related protein induced both hyperphosphataemia and…”
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Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor by Shimizu, Kazuo, Fujikura, Hideki, Fushimi, Nobuhiko, Nishimura, Toshihiro, Tatani, Kazuya, Katsuno, Kenji, Fujimori, Yoshikazu, Watanabe, Shinjiro, Hiratochi, Masahiro, Nakabayashi, Takeshi, Kamada, Noboru, Arakawa, Koichi, Hikawa, Hidemasa, Azumaya, Isao, Isaji, Masayuki

“…[Display omitted] We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to…”
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Remogliflozin Etabonate Improves Fatty Liver Disease in Diet-Induced Obese Male Mice by Nakano, Shigeru, Katsuno, Kenji, Isaji, Masayuki, Nagasawa, Tatsuya, Buehrer, Benjamin, Walker, Susan, Wilkison, William O, Cheatham, Bentley

“…Background Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) are serious conditions and are being diagnosed at an increased rate. The…”
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Inhibitory Effects of Tranilast on the Proliferation and Functions of Human Pterygium-derived Fibroblasts by Isaji, Masayuki, Kikuchi, Shinji, Miyata, Hiroshi, Ajisawa, Yukiyoshi, Araki-Inazawa, Kaori, Tsukamoto, Yuji, Amano, Yoshinari

“…PURPOSE.We studied the possibility that tranilast, an antiallergic and antiproliferative drug, may be beneficial for the treatment of pterygium…”
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Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in rats by Isaji, Masayuki, Miyata, Hiroshi, Ajisawa, Yukiyoshi, Yoshimura, Nagahisa

“…We studied the effects of tranilast, an anti-allergic and anti-proliferative drug in clinical use, on VEGF/VPF-induced vascular permeability in a rat air pouch…”
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Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice by Katsuno, Kenji, Fujimori, Yoshikazu, Ishikawa-Takemura, Yukiko, Isaji, Masayuki

“…Sergliflozin etabonate, a novel oral selective low-affinity sodium glucose cotransporter (SGLT2) inhibitor, improves hyperglycemia by suppressing renal glucose…”
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Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides by Hiratochi, Masahiro, Tatani, Kazuya, Shimizu, Kazuo, Kuramochi, Yu, Kikuchi, Norihiko, Kamada, Noboru, Itoh, Fumiaki, Isaji, Masayuki

“…We have developed concentrative nucleoside transporter 2 (CNT2) inhibitors as a novel pharmacological approach for improving hyperuricemia by inhibiting…”
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Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase by Tsuji, Eiichi, Okazaki, Kosuke, Isaji, Masayuki, Takeda, Kei

“…Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a monomeric enzyme that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to…”
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