Search Results - "Isaguliants, M G"

Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer by Baklaushev, V. P., Kilpeläinen, A., Petkov, S., Abakumov, M. A., Grinenko, N. F., Yusubalieva, G. M., Latanova, A. A., Gubskiy, I. L., Zabozlaev, F. G., Starodubova, E. S., Abakumova, T. O., Isaguliants, M. G., Chekhonin, V. P.

“…Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk of their immune elimination. We have studied this effect in a mouse…”
Get full text

Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity by Latanova, A. A., Petkov, S., Kilpelainen, A., Jansons, J., Latyshev, O. E., Kuzmenko, Y. V., Hinkula, J., Abakumov, M. A., Valuev-Elliston, V. T., Gomelsky, M., Karpov, V. L., Chiodi, F., Wahren, B., Logunov, D. Y., Starodubova, E. S., Isaguliants, M. G.

“…DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak…”
Get full text

Therapeutic Vaccines Against Human Papilloma Viruses: Achievements and Prospects by Vonsky, M. S., Runov, A. L., Gordeychuk, I. V., Isaguliants, M. G.

“…Human papillomaviruses of high carcinogenic risk (HR HPVs) are major etiological agents of malignant diseases of the cervix, vulva, penis, anal canal, larynx,…”
Get full text

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context by Mikhaylov, Mikhail I., Isaeva, O. V., Karlsen, A. A., Soboleva, N. V., Kyuregyan, K. K., Kichatova, V. S., Isaguliants, Maria

“…Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of…”
Get full text

Assessment of the Parameters of Adaptive Cell-Mediated Immunity in Naïve Common Marmosets (Callithrix jacchus) by Gordeychuk, I V, Tukhvatulin, A I, Petkov, S P, Abakumov, M A, Gulyaev, S A, Tukhvatulina, N M, Gulyaeva, T V, Mikhaylov, M I, Logunov, D Y, Isaguliants, M G

“…Common marmosets are small New World primates that have been increasingly used in biomedical research. This report presents efficient protocols for assessment…”
Get full text

Influence of Drug Resistance Mutations on the Activity of HIV-1 Subtypes A and B Integrases: a Comparative Study by Shadrina, O A, Zatsepin, T S, Agapkina, Yu Yu, Isaguliants, M G, Gottikh, M B

“…Integration of human immunodeficiency virus (HIV-1) DNA into the genome of an infected cell is one of the key steps in the viral replication cycle. The viral…”
Get full text

Expression of HIV-1 Reverse Transcriptase in Murine Cancer Cells Increases Mitochondrial Respiration by Zakirova, N. F., Kondrashova, A. S., Golikov, M. V., Ivanova, O. N., Ivanov, A. V., Isaguliants, M. G., Bayurova, E. O.

“…— Changes in metabolic pathways are often associated with the development of a wide range of pathologies. Increased glycolysis under conditions of sufficient…”
Get full text

Fusion to the Lysosome Targeting Signal of the Invariant Chain Alters the Processing and Enhances the Immunogenicity of HIV-1 Reverse Transcriptase by Starodubova, E S, Isaguliants, M G, Kuzmenko, Y V, Latanova, A A, Krotova, O A, Karpov, V L

“…Intracellular processing of the antigen encoded by a DNA vaccine is one of the key steps in generating an immune response. Immunization with DNA constructs…”
Get full text

HCV and oxidative stress in the liver by Ivanov, Alexander V, Bartosch, Birke, Smirnova, Olga A, Isaguliants, Maria G, Kochetkov, Sergey N

“…Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2-3% of the population worldwide. HCV infection often…”
Get full text

Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines by Starodubova, E S, Isaguliants, M G, Karpov, V L

“…Immunization with naked genes (DNA-immunization) is a perspective modern approach to prophylactic as well as therapeutic vaccination against pathogens, as well…”
Get full text

Sequence-Specific Minor Groove Binding Ligands as Potential Regulators of Gene Expression in Xenopus Laevis Oocytes by Belikov, S. V., Grokhovsky, S. L., Isaguliants, M. G., Surovaya, A. N., Gursky, G. V.

“…The mouse mammary tumor virus (MMTV) promoter is induced by glucocorticoid hormone. A robust hormone- and receptor-dependent gene activation could be…”
Get full text

Analysis of the Domains of Hepatitis C Virus Core and NS5A Proteins that Activate the Nrf2/ARE Cascade by Smirnova, O A, Ivanova, O N, Mukhtarov, F Sh, Tunitskaya, V L, Jansons, J, Isaguliants, M G, Kochetkov, S N, Ivanov, A V

“…The hepatitis C virus (HCV) triggers a chronic disease that is often accompanied by a spectrum of liver pathologies and metabolic alterations. The oxidative…”
Get full text

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits by Isaguliants, M G, Gudima, S O, Ivanova, O V, Levi, M, Hinkula, J, Garaev, M M, Kochetkov, S N, Wahren, B

“…Genetic immunization may be one way to prime individuals for a subsequent broad anti-HIV-1 immune response. Reverse transcriptase of HIV-1 (RT) presents a…”
Get more information

Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA by Zuber, Anne Kjerrström, Bråve, Andreas, Engström, Gunnel, Zuber, Bartek, Ljungberg, Karl, Fredriksson, Malin, Benthin, Reinhold, Isaguliants, Maria G, Sandström, Eric, Hinkula, Jorma, Wahren, Britta

“…We evaluated the compound imiquimod as a possible adjuvant for DNA immunization against human immunodeficiency virus (HIV). We found that gene-gun epidermal…”
Get full text

Artificial acceleration of HIV-1 reverse transcriptase turnover via the proteasome pathway by Starodubova, E S, Isaguliants, M G, Karpov, V L

“…Since the proteasome plays a key role in antigen presentation in complex with MHC class I molecules, it is promising to increase the proteasomal targeting of…”
Get full text

Specificity of humoral and cellular immune response against recombinant particles of nucleocapsid protein of human hepatitis B virus in rabbits by Isaguliants, M G, Kadoshnikov, Y P, Kalinina, T I, Smirnov, V D, Wahren, B

“…Nucleocapsid (core) protein of hepatitis B virus (HBcAg) induces potent cellular and humoral responses that have a clear protective potential. Rabbits were…”
Get more information

HIV-1 epitopes exposed by hybrid hepatitis B core particles affect proliferation of peripheral blood mononuclear cells from HIV-1 positive donors by Isaguliants, M.G., Nordlund, S., Sällberg, M., Smirnov, V.D., Rudén, U., Wahren, B.

“…Hepatitis B virus core protein (HBc) in particulate form is a potent immunogen for the design of vaccines with a broad T-cell reactivity. Hybrid HBc proteins…”
Get full text

Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells by Isaguliants, Maria G., Petrakova, Natalia V., Kashuba, Elena V., Suzdaltzeva, Yulia G., Belikov, Sergey V., Mokhonov, Vladislav V., Prilipov, Alexei G., Matskova, Ludmila, Smirnova, Irina S., Jolivet-Reynaud, Colette, Nordenfelt, Erik

“…Numerous attempts to induce immunity against HCV core (HCV-C) by DNA immunization met serious difficulties in optimizing T-helper cell and antibody responses…”
Get full text

Gene immunization may induce secondary antibodies reacting with DNA by Isaguliants, Maria G, Iakimtchouk, Konstantin, Petrakova, Natalia V, Yermalovich, Marina A, Zuber, Anne Kjerrström, Kashuba, Vladimir I, Belikov, Sergey V, Andersson, Sören, Kochetkov, Sergey N, Klinman, Dennis M, Wahren, Britta

“…The fear of autoimmunity in DNA-vaccine recipients initiated screening for anti-DNA antibodies in rabbits immunized with genes of viral nucleic acid-binding…”
Get full text

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model by Isaguliants, Maria G., Zuber, Bartek, Boberg, Andreas, Sjöstrand, Dan, Belikov, Sergey V., Rollman, Erik, Zuber, Anne Kjerrström, Rechinsky, Vladimir O., Rytting, Ann-Sofie, Källander, Clas F.R., Hinkula, Jorma, Kochetkov, Sergey N., Liu, Margaret, Wahren, Britta

“…Drug resistance is becoming a problem in the treatment of the human immunodeficiency virus type one (HIV-1). To obtain therapeutic DNA vaccines that would…”
Get full text