The Experience of Using Multipotent Mesenchymal Stromal Cells in the Treatment of Severe Recurrent Cholangitis in Children with Biliary Atresia after Kasai Surgery

This article describes the experience of application of multipotent mesenchymal stromal cells in the complex therapy of severe recurrent cholangitis in 2 children with biliary atresia after Kasai surgery. In both children, hepatic cellular insufficiency and portal hypertension developed against the...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 174; no. 1; pp. 164 - 173
Main Authors:	Degtyareva, A. V., Isaeva, М. H., Silachev, D. N., Goryunov, K. V., Shevtsova, Yu. А., Dubrovina, I. V., Burov, A. A., Filippova, E. A., Zubkov, V. V., Krechetova, L. V., Vtorushina, V. V., Inviyaeva, E. V., Sukhikh, G. T.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-11-2022 Springer Springer Nature B.V
Subjects:	Biliary atresia Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Cell therapy Children Cholangitis Complications Health aspects Hypertension Inflammation Internal Medicine Laboratory Medicine Liver Liver transplantation Mesenchymal stem cells Mesenchyme Pathology Postoperative Recovery of function Stem cells Stromal cells Surgery Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Transplantation of organs, tissues, etc biliary atresia cholangitis cell therapy mesenchymal stromal cells
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Summary:	This article describes the experience of application of multipotent mesenchymal stromal cells in the complex therapy of severe recurrent cholangitis in 2 children with biliary atresia after Kasai surgery. In both children, hepatic cellular insufficiency and portal hypertension developed against the background of long-term inflammatory process poorly controlled by standard therapy, which was the indication for liver transplantation. During the course of mesenchymal stromal cells therapy, the relief of the inflammatory process and functional recovery of the liver were achieved. At the time of preparing the article, the follow-up of two children since the start of multipotent mesenchymal stromal cell therapy was 3 years 9 months and 2 years 6 months. No recurrence of cholangitis was observed in the patients during the follow-up period, the liver function was preserved. There are no indications for liver transplantation at this moment. Thus, despite the fact that the mechanisms of therapeutic action of multipotent mesenchymal stromal cells in biliary atresia require further investigation, we obtained promising results suggesting the possibility of using mesenchymal stromal cells in the treatment of postoperative complications in children with biliary atresia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-022-05667-0