Search Results - "Isacke, C M"

Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance by Plaza-Menacho, I, Morandi, A, Robertson, D, Pancholi, S, Drury, S, Dowsett, M, Martin, L-A, Isacke, C M

“…Endocrine therapy is the main therapeutic option for patients with estrogen receptor (ERα)-positive breast cancer. Resistance to this treatment is often…”
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Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome by Henry, L A, Johnson, D A, Sarrió, D, Lee, S, Quinlan, P R, Crook, T, Thompson, A M, Reis-Filho, J S, Isacke, C M

“…Tumor growth factor-β (TGF-β) signaling in cancer has been implicated in growth suppression of early lesions and enhancing tumor cell invasion and metastasis…”
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Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts by Esseghir, S, Reis-Filho, JS, Kennedy, A, James, M, O'Hare, MJ, Jeffery, R, Poulsom, R, Isacke, CM

“…This study demonstrates, through a combination of stringent screening methods and thorough validation, that it is possible to identify transmembrane proteins…”
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Expression of Endo180 is spatially and temporally regulated during wound healing by Honardoust, H A, Jiang, G, Koivisto, L, Wienke, D, Isacke, C M, Larjava, H, Häkkinen, L

“…Aims:  Interactions of cells with the extracellular matrix are important for normal wound healing and may play a role in scar formation. Remarkably, wound…”
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A comparative proteinomic analysis of nipple aspiration fluid from healthy women and women with breast cancer by Noble, J.L, Dua, R.S, Coulton, G.R, Isacke, C.M, Gui, G.P.H

“…Abstract This pilot study examines the feasibility of nipple aspiration to distinguish women with breast cancer from healthy women using surface-enhanced laser…”
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Directional sensing of a phorbol ester gradient requires CD44 and is regulated by CD44 phosphorylation by TZIRCOTIS, G, THORNE, R. F, ISACKE, C. M

“…Cancer progression is associated with enhanced directional cell migration, both of the tumour cells invading into the stroma and stromal cells infiltrating the…”
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The role of cytoplasmic domain in regulating CD44 function by ISACKE, C. M

“…ABSTRACT…”
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Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? by Sartelet, A., Klingbeil, P., Franklin, C. K., Fasquelle, C., Géron, S., Isacke, C. M., Georges, M., Charlier, C.

“…Summary We report the identification of a second loss‐of‐function mutation (c.1906T>C) in the bovine MRC2 gene causing the Crooked Tail Syndrome in Belgian…”
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Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning by WHEATLEY, S. C, ISACKE, C. M, CROSSLEY, P. H

“…CD44 is a multifunctional adhesion protein that acts as a major receptor for the hygroscopic extracellular matrix component, hyaluronan. This receptor-ligand…”
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The Cytoplasmic Tail of CD44 Is Required for Basolateral Localization in Epithelial MDCK Cells but Does Not Mediate Association with the Detergent-Insoluble Cytoskeleton of Fibroblasts by Neame, Stephen J., Isacke, Clare M.

“…A number of recent reports on the trafficking of receptor proteins in MDCK epithelial cells have provided evidence that delivery to the basolateral domain…”
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The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo by GOULD, C. L, WOODGETT, J. R, ISACKE, C. M, HUNTER, T

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Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin‐related peptide, gastrin‐releasing peptide by Isacke, C.M., Meisenhelder, J., Brown, K.D., Gould, K.L., Gould, S.J., Hunter, T.

“…Bombesin and the related mammalian peptides, such as gastrin‐releasing peptide (GRP), are potent mitogens for some fibroblast cell lines. Here we have examined…”
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Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids by ISACKE, C. M, LINDBERG, R. A, HUNTER, T

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Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44 by Legg, James W., Isacke, Clare M.

“…ERM (ezrin, radixin and moesin) proteins function as linkers between the actin cytoskeleton and the plasma membrane (reviewed in [1–3]). In addition to this…”
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Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor by Sheikh, H, Yarwood, H, Ashworth, A, Isacke, C M

“…Endo180 was previously characterized as a novel, cell type specific, recycling transmembrane glycoprotein. This manuscript describes the isolation of a full…”
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Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies by ISACKE, C. M, TROWBRIDGE, I. S, HUNTER, T

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Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan by Lewis, C A, Townsend, P A, Isacke, C M

“…CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell…”
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GPI-Anchored uPAR Requires Endo180 for Rapid Directional Sensing during Chemotaxis by Sturge, Justin, Wienke, Dirk, East, Lucy, Jones, Gareth E., Isacke, Clare M.

“…Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological…”
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p180, a novel recycling transmembrane glycoprotein with restricted cell type expression by Isacke, C M, van der Geer, P, Hunter, T, Trowbridge, I S

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Structural heterogeneity of human Pgp-1 and its relationship with p85 by OMARY, M. B, TROWBRIDGE, I. S, LETARTE, M, KAGNOFF, M. F, ISACKE, C. M

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