Search Results - "Isabelle E. J. A. François"

In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis by TAVARES, Patricia M, THEVISSEN, Karin, CAMMUE, Bruno P. A, FRANCOIS, Isabelle E. J. A, BARRETO-BERGTER, Eliana, TABORDA, Carlos P, MARQUES, Alexandre F, RODRIGUES, Marcio L, NIMRICHTER, Leonardo

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Therapeutic potential of antifungal plant and insect defensins by Thevissen, Karin, Kristensen, Hans-Henrik, Thomma, Bart P.H.J., Cammue, Bruno P.A., François, Isabelle E.J.A.

“…To defend themselves against invading fungal pathogens, plants and insects largely depend on the production of a wide array of antifungal molecules, including…”
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A putative novel role for plant defensins: a defensin from the zinc hyper‐accumulating plant, Arabidopsis halleri, confers zinc tolerance by Mirouze, Marie, Sels, Jan, Richard, Odile, Czernic, Pierre, Loubet, Stéphanie, Jacquier, Amaury, François, Isabelle E.J.A., Cammue, Bruno P.A., Lebrun, Michel, Berthomieu, Pierre, Marquès, Laurence

“…Summary The metal tolerance of metal hyper‐accumulating plants is a poorly understood mechanism. In order to unravel the molecular basis of zinc (Zn) tolerance…”
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Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial by François, Isabelle E. J. A., Lescroart, Olivier, Veraverbeke, Wim S., Marzorati, Massimo, Possemiers, Sam, Evenepoel, Pieter, Hamer, Henrike, Houben, Els, Windey, Karen, Welling, Gjalt W., Delcour, Jan A., Courtin, Christophe M., Verbeke, Kristin, Broekaert, Willem F.

“…Wheat bran extract (WBE) is a food-grade soluble fibre preparation that is highly enriched in arabinoxylan oligosaccharides. In this placebo-controlled…”
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Arabinoxylan-oligosaccharides (AXOS) reduce preneoplastic lesions in the colon of rats treated with 1,2-dimethylhydrazine (DMH) by Femia, Angelo Pietro, Salvadori, Maddalena, Broekaert, Willem F, François, Isabelle E. J. A, Delcour, Jan A, Courtin, Christophe M, Caderni, Giovanna

“…Background Prebiotics are non-digestible compounds that beneficially affect the host by stimulating the growth and/or activity of one or a limited number of…”
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Transgenic Expression in Arabidopsis of a Polyprotein Construct Leading to Production of Two Different Antimicrobial Proteins by Isabelle E. J. A. François, Miguel F. C. De Bolle, Geoff Dwyer, Inge J. W. M. Goderis, Piet F. J. Woutors, Peter D. Verhaert, Paul Proost, Wim M. M. Schaaper, Bruno P. A. Cammue, Broekaert, Willem F.

“…We developed a method for expression in Arabidopsis of a transgene encoding a cleavable chimeric polyprotein. The polyprotein precursor consists of a leader…”
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Membrane Rafts Are Involved in Intracellular Miconazole Accumulation in Yeast Cells by François, Isabelle E.J.A., Bink, Anna, Vandercappellen, Jo, Ayscough, Kathryn R., Toulmay, Alexandre, Schneiter, Roger, van Gyseghem, Elke, Van den Mooter, Guy, Borgers, Marcel, Vandenbosch, Davy, Coenye, Tom, Cammue, Bruno P.A., Thevissen, Karin

“…Azoles inhibit ergosterol biosynthesis, resulting in ergosterol depletion and accumulation of toxic 14α-methylated sterols in membranes of susceptible yeast…”
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Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins by Aerts, An M, Thevissen, Karin, Bresseleers, Sara M, Sels, Jan, Wouters, Piet, Cammue, Bruno P. A, François, Isabelle E. J. A

“…Human beta-defensin-2 (hBD-2) is a small antimicrobial peptide with potent activity against different Gram-negative bacteria and fungal/yeast species. Since…”
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Novel fungicidal benzylsulfanyl-phenylguanidines by Thevissen, Karin, Pellens, Klaartje, De Brucker, Katrijn, François, Isabelle E.J.A., Chow, Kwok K., Meert, Els M.K., Meert, Wim, Van Minnebruggen, Geert, Borgers, Marcel, Vroome, Valérie, Levin, Jeremy, De Vos, Dirk, Maes, Louis, Cos, Paul, Cammue, Bruno P.A.

“…Benzylsulfanyl-phenylguanidines 665 and 667 combined potent fungicidal and bactericidal activity. These compounds exhibited minor toxicity in a Caenorhabditis…”
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Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae by Thevissen, Karin, Yen, Wei-Lien, Carmona-Gutierrez, Didac, Idkowiak-Baldys, Jolanta, Aerts, An M, François, Isabelle E.J.A, Madeo, Frank, Klionsky, Daniel J, Hannun, Yusuf A, Cammue, Bruno P.A

“…We demonstrated that a yeast deletion mutant in IPT1 and SKN1, encoding proteins involved in the biosynthesis of mannosyldiinositolphosphoryl ceramides, is…”
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The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans by Aerts, An M., Carmona-Gutierrez, Didac, Lefevre, Sophie, Govaert, Gilmer, François, Isabelle E.J.A., Madeo, Frank, Santos, Renata, Cammue, Bruno P.A., Thevissen, Karin

“…We show that the antifungal plant defensin Raphanus sativus antifungal protein 2 (RsAFP2) from radish induces apoptosis and concomitantly triggers activation…”
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Effects of Wheat Bran Extract Containing Arabinoxylan Oligosaccharides on Gastrointestinal Parameters in Healthy Preadolescent Children by François, Isabelle E.J.A., Lescroart, Olivier, Veraverbeke, Wim S., Marzorati, Massimo, Possemiers, Sam, Hamer, Henrike, Windey, Karen, Welling, Gjalt W., Delcour, Jan A., Courtin, Christophe M., Verbeke, Kristin, Broekaert, Willem F.

“…ABSTRACT Objectives: We assessed whether wheat bran extract (WBE) containing arabinoxylan‐oligosaccharides (AXOS) elicited a prebiotic effect and modulated…”
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Tolerance and the effect of high doses of wheat bran extract, containing arabinoxylan–oligosaccharides, and oligofructose on faecal output: a double-blind, randomised, placebo-controlled, cross-over trial by François, Isabelle E. J. A., Lescroart, Olivier, Veraverbeke, Wim S., Windey, Karen, Verbeke, Kristin, Broekaert, Willem F.

“…Wheat bran extract (WBE) is a food-grade soluble fibre preparation that is highly enriched in arabinoxylan–oligosaccharides. In this placebo-controlled…”
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Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast by Thevissen, Karin, Ayscough, Kathryn R., Aerts, An M., Du, Wei, De Brucker, Katrijn, Meert, Els M.K., Ausma, Jannie, Borgers, Marcel, Cammue, Bruno P.A., François, Isabelle E.J.A.

“…The antifungal compound miconazole inhibits ergosterol biosynthesis and induces reactive oxygen species (ROS) in susceptible yeast species. To further uncover…”
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DmAMP1, an antifungal plant defensin from dahlia ( Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae by Thevissen, Karin, François, Isabelle E.J.A, Takemoto, Jon Y, Ferket, Kathelijne K.A, Meert, Els M.K, Cammue, Bruno P.A

“…DmAMP1, an antifungal plant defensin from Dahlia merckii, was shown previously to require the presence of sphingolipids for fungicidal action against…”
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Fungicidal activity of truncated analogues of dihydrosphingosine by Thevissen, Karin, Hillaert, Ulrik, Meert, Els M.K., Chow, Kuen K., Cammue, Bruno P.A., Van Calenbergh, Serge, François, Isabelle E.J.A.

“…Truncated dihydrosphingosine (DHS) derivatives have been evaluated for antifungal activity. DHS derivatives with C15 or C17 showed 10-fold increased fungicidal…”
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Antifungal activity of synthetic peptides derived from Impatiens balsamina antimicrobial peptides Ib-AMP1 and Ib-AMP4 by Thevissen, Karin, François, Isabelle E.J.A., Sijtsma, Lolke, Amerongen, Aart van, Schaaper, Wim M.M., Meloen, Rob, Posthuma-Trumpie, Truus, Broekaert, Willem F., Cammue, Bruno P.A.

“…Seeds of Impatiens balsamina contain a set of related antimicrobial peptides (Ib-AMPs). We have produced a synthetic variant of Ib-AMP1, oxidized to the…”
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Safety Assessment of a Wheat Bran Extract Containing Arabinoxylan-Oligosaccharides: Mutagenicity, Clastogenicity, and 90-Day Rat-Feeding Studies by François, Isabelle E. J. A., Lescroart, Olivier, Veraverbeke, Wim S., Kubaszky, Raluca, Hargitai, Judit, Esdaile, David J., Beres, Erzsébet, Soni, Madhu G., Cockburn, Andrew, Broekaert, Willem F.

“…Wheat bran extract (WBE) is a food-grade preparation that is highly enriched in arabinoxylan-oligosaccharides. As part of the safety evaluation of WBE, its…”
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Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives by François, Isabelle E.J.A., Cammue, Bruno P.A., Bresseleers, Sara, Fleuren, Hein, Hoornaert, Georges, Mehta, Vaibhav P., Modha, Sachin G., Van der Eycken, Erik V., Thevissen, Karin

“…A family of pyrazinone derivatives has been synthesized and the in vitro fungicidal activity against Candida albicans was analyzed. Compounds 11 and 20 were…”
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Neutral glycolipids of the filamentous fungus Neurospora crassa:altered expression in plant defensin-resistant mutants by Park, Chaeho, Bennion, Beau, François, Isabelle E.J.A., Ferket, Kathelijne K.A., Cammue, Bruno P.A., Thevissen, Karin, Levery, Steven B.

“…To defend themselves against fungal pathogens, plants produce numerous antifungal proteins and peptides, including defensins, some of which have been proposed…”
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