Search Results - "Isaac Quiros-Fernandez"

Dual T cell receptor/chimeric antigen receptor engineered NK‐92 cells targeting the HPV16 E6 oncoprotein and the tumor‐associated antigen L1CAM exhibit enhanced cytotoxicity and specificity against tumor cells by Quiros‐Fernandez, Isaac, Libório‐Ramos, Sofia, Leifert, Lena, Schönfelder, Bruno, Vlodavsky, Israel, Cid‐Arregui, Angel

“…The human papillomavirus type 16 (HPV16) causes a large fraction of genital and oropharyngeal carcinomas. To maintain the transformed state, the tumor cells…”
Get full text

Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle by José Arturo Molina-Mora, Susana Mesen-Porras, Isaac Quiros-Fernandez, Mariana Kop-Montero, Andrea Rojas-Cespedes, Steve Quiros, Francisco Siles, Rodrigo Mora

“…Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and drug multiresistance emergence. The sphingolipid (SL)…”
Get full text

Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals by Quiros-Fernandez, Isaac, Poorebrahim, Mansour, Fakhr, Elham, Cid-Arregui, Angel

“…Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of…”
Get full text

Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells by Quiros-Fernandez, Isaac, Figueroa-Protti, Lucía, Arias-Arias, Jorge L, Brenes-Cordero, Norman, Siles, Francisco, Mora, Javier, Mora-Rodríguez, Rodrigo Antonio

“…In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting…”
Get full text

A costimulatory chimeric antigen receptor targeting TROP2 enhances the cytotoxicity of NK cells expressing a T cell receptor reactive to human papillomavirus type 16 E7 by Poorebrahim, Mansour, Quiros-Fernandez, Isaac, Marmé, Frederik, Burdach, Stefan EG, Cid-Arregui, Angel

“…Immune cells modified to express a tumor-reactive T cell receptor (TCR) have shown limited efficacy as stand-alone therapy against solid tumors. Genital and…”
Get full text

Generation of CAR-T cells using lentiviral vectors by Poorebrahim, Mansour, Quiros-Fernandez, Isaac, Fakhr, Elham, Cid-Arregui, Angel

“…Cancer immunotherapy is nowadays largely focused on the development of therapeutic antibodies and chimeric antigen receptors (CARs). Two CARs targeting CD19…”
Get full text