Search Results - "Isa, Kaoru"
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Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues
Published in Nature communications (27-04-2020)“…Whole-organ/body three-dimensional (3D) staining and imaging have been enduring challenges in histology. By dissecting the complex physicochemical environment…”
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Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus
Published in Nature communications (11-01-2019)“…In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness…”
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Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex
Published in Neuroscience research (01-04-2015)“…Here we investigated the transduction characteristics of adeno-associated viral vector (AAV) serotypes 1, 2, 5, 8 and 9 in the marmoset cerebral cortex. Using…”
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Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys
Published in Proceedings of the National Academy of Sciences - PNAS (17-01-2017)“…The direct cortico-motoneuronal connection is believed to be essential for the control of dexterous hand movements, such as precision grip in primates. It was…”
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Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety
Published in Gene therapy (01-06-2021)“…Pathway-selective gene delivery would be critical for future gene therapy against neuropsychiatric disorders, traumatic neuronal injuries, or neurodegenerative…”
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Genetic dissection of the circuit for hand dexterity in primates
Published in Nature (London) (12-07-2012)“…A new double-infection technique with viral vectors is used to interrupt transmission through the propriospinal neurons (PNs) in macaque monkeys, and this is…”
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Stage-dependent role of interhemispheric pathway for motor recovery in primates
Published in Nature communications (22-08-2024)“…Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the…”
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Dissecting the Tectal Output Channels for Orienting and Defense Responses
Published in eNeuro (01-09-2020)“…Electrical stimulation and lesion experiments in 1980's suggested that the crossed descending pathway from the deeper layers of superior colliculus (SCd)…”
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Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis
Published in Scientific reports (12-09-2022)“…Tyramide signal amplification (TSA) is a highly sensitive method for histochemical analysis. Previously, we reported a TSA system, biotinyl tyramine-glucose…”
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Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus
Published in Frontiers in neural circuits (07-01-2022)“…In our previous study, we showed that the defense responses induced by the selective optogenetic activation of the uncrossed output pathway from the deeper…”
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Nigral Inhibition of GABAergic Neurons in Mouse Superior Colliculus
Published in The Journal of neuroscience (22-10-2008)“…The current dominant concept for the control of saccadic eye movements by the basal ganglia is that release from tonic GABAergic inhibition by the substantia…”
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Protocol for making an animal model of “blindsight” in macaque monkeys
Published in STAR protocols (17-03-2023)“…Patients with damage to the primary visual cortex (V1) can respond correctly to visual stimuli in their lesion-affected visual field above the chance level, an…”
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Formation of descending pathways mediating cortical command to forelimb motoneurons in neonatally hemidecorticated rats
Published in Journal of neurophysiology (01-09-2010)“…Neonatally hemidecorticated rats show fairly normal reaching and grasping behaviors of the forelimb contralateral to the lesion at the adult stage. Previous…”
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Organization of GABAergic inhibition in the motor output layer of the superior colliculus
Published in The European journal of neuroscience (01-02-2011)“…The direction and amplitude of saccadic eye movements are determined by the location of the center of gravity of burst activity over a neuronal population on…”
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Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF
Published in iScience (21-01-2022)“…The mammalian brain is organized over sizes that span several orders of magnitude, from synapses to the entire brain. Thus, a technique to visualize neural…”
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Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains
Published in IEEE access (2021)“…Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices…”
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Large-scale reorganization of corticofugal fibers after neonatal hemidecortication for functional restoration of forelimb movements
Published in The European journal of neuroscience (01-11-2009)“…As an experimental model to study the mechanism of large‐scale network plasticity of the juvenile brain, functional compensation after neonatal brain damage…”
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Reorganization of sensory pathways after neonatal hemidecortication in rats
Published in Neuroscience research (01-02-2014)“…We investigated ascending somatosensory pathways in neonatally hemidecorticated rats. Injection of an anterograde tracer, biotinylated dextran amine (BDA),…”
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Identity of a pathway for saccadic suppression
Published in Proceedings of the National Academy of Sciences - PNAS (17-04-2007)“…Neurons in the superficial gray layer (SGS) of the superior colliculus receive visual input and excite intermediate layer (SGI) neurons that play a critical…”
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Cholinergic Responses in Crossed Tecto-Reticular Neurons of Rat Superior Colliculus
Published in Journal of neurophysiology (01-11-2008)“…1 Department of Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; 2 Department of Developmental Physiology, National…”
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