Search Results - "Irwin, Scott M"

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis by DRIVER, Emily R, RYAN, Gavin J, HOFF, Donald R, IRWIN, Scott M, BASARABA, Randall J, KRAMNIK, Igor, LENAERTS, Anne J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis by Irwin, Scott M, Driver, Emily, Lyon, Edward, Schrupp, Christopher, Ryan, Gavin, Gonzalez-Juarrero, Mercedes, Basaraba, Randall J, Nuermberger, Eric L, Lenaerts, Anne J

“…Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel…”
Get full text

Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis by Henao-Tamayo, Marcela I, Ordway, Diane J, Irwin, Scott M, Shang, Shaobin, Shanley, Crystal, Orme, Ian M

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives by Via, Laura E, Savic, Rada, Weiner, Danielle M, Zimmerman, Matthew D, Prideaux, Brendan, Irwin, Scott M, Lyon, Eddie, O’Brien, Paul, Gopal, Pooja, Eum, Seokyong, Lee, Myungsun, Lanoix, Jean-Philippe, Dutta, Noton K, Shim, TaeSun, Cho, Jeong Su, Kim, Wooshik, Karakousis, Petros C, Lenaerts, Anne, Nuermberger, Eric, Barry, Clifton E, Dartois, Véronique

“…Pyrazinamide has played a critical role in shortening therapy against drug-sensitive, drug-resistant, active, and latent tuberculosis (TB). Despite widespread…”
Get full text

Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein by Irwin, Scott M, Izzo, Angelo A, Dow, Steven W, Skeiky, Y. A. W, Reed, Steven G, Alderson, Mark R, Orme, Ian M

“…This study used a major histocompatibility complex class I tetramer reagent to track antigen-specific CD8 T cells in the lungs of mice immunized with the…”
Get full text

Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas by IRWIN, Scott M, GRUPPO, Veronica, LENAERTS, Anne J, BROOKS, Elizabeth, GILLILAND, Janet, SCHERMAN, Michael, REICHLEN, Matthew J, LEISTIKOW, Rachel, KRAMNIK, Igor, NUERMBERGER, Eric L, VOSKUIL, Martin I

“…New drugs and drugs with a novel mechanism of action are desperately needed to shorten the duration of tuberculosis treatment, to prevent the emergence of drug…”
Get full text

Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models by Li, Si-Yang, Irwin, Scott M, Converse, Paul J, Mdluli, Khisi E, Lenaerts, Anne J, Nuermberger, Eric L

“…In the recently concluded REMox-TB trial, two 4-month moxifloxacin-containing regimens did not meet the criteria for noninferiority compared to the current…”
Get full text

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice by Irwin, Scott M, Prideaux, Brendan, Lyon, Edward R, Zimmerman, Matthew D, Brooks, Elizabeth J, Schrupp, Christopher A, Chen, Chao, Reichlen, Matthew J, Asay, Bryce C, Voskuil, Martin I, Nuermberger, Eric L, Andries, Koen, Lyons, Michael A, Dartois, Véronique, Lenaerts, Anne J

“…BALB/c and Swiss mice are routinely used to validate the effectiveness of tuberculosis drug regimens, although these mouse strains fail to develop human-like…”
Get full text

T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis by Henao-Tamayo, Marcela, Irwin, Scott M, Shang, Shaobin, Ordway, Diane, Orme, Ian M

“…Summary Predictive biomarkers illustrating the effectiveness of chemotherapeutic regimens for tuberculosis still remain elusive. To date, most are predicated…”
Get full text

Sensitization with atypical mycobacteria is a potent risk factor for cross-reaction with the delayed type hypersensitivity assay in mice by Junqueira Kipnis, Ana Paula

“…Tuberculosis is a disease that infects approximately two billion people worldwide. The current diagnostic test utilizes purified protein derivative (PPD)…”
Get full text

Rapid Treatments for Depression and Anxiety (411-B) by Irwin, Scott, MD PhD

Get full text

“Mr. Smith Killed Himself Last Night”: The Scope of Suicidality in Hospice Care (TH302) by Meier, Martina, MD, Prommer, Eric, MD HMDC FAAHPM, Irwin, Scott, MD PhD, Deslauriers, Shannon, MSW, Ortolano, Richard, MA

“…Information about the session entitled, "Mr. Smith Killed Him Last Night": The Scope of Suicidality in Hospice Care (TH302) is presented. The objectives of the…”
Get full text

A Retrospective Case Series of Suicide Attempts Leading to Hospice Admission (417-C) by Fairman, Nathan, MD MPH, Irwin, Scott, MD PhD

Get full text

Ketamine for the Management of Depression in Palliative Care: An Update on the Science (FR413) by Irwin, Scott, MD PhD, Hirst, Jeremy, MD, Fairman, Nathan, MD MPH, Prommer, Eric, MD FAAHPM

Get full text

Can Delirium Be Prevented in Palliative Care? Incorporating the Lessons of Geriatrics, Oncology, and Surgery (505) by Shega, Joe, MD, Reidy, Jennifer, MD, Irwin, Scott, MD PhD

Get full text

The role of CD8 T cells during pulmonary infection with Mycobacterium tuberculosis by Irwin, Scott M

“…With over 8 million deaths per year and incidence rates increasing in many countries, tuberculosis is a world-wide pandemic which has not been effectively…”
Get full text

A Retrospective Case Series of Completed Suicides in Hospice (417-B) by Fairman, Nathan, MD MPH, Morrison, Katherine, MD, Ligon, Kathy, MD, Nelesen, Richard, PhD, Irwin, Scott, MD PhD

Get full text

Delirium: A Study of Difficult Cases (329) by Weckmann, Michelle, MD MS, Irwin, Scott, MD PhD, Hirst, Jeremy, MD, von Gunten, Charles, MD PhD FAAHPM FACP

Get full text

A Retrospective Chart Review of the Efficacy of Ketamine for Depression in Patients Receiving Hospice Care (FR416-A) by Morrison, Katherine, MD, Irwin, Scott, MD PhD, Nelesen, Richard, PhD, Ligon, Kathy, MD, Koo, Derek, BS, Fairman, Nathan, MD MPH, Aiglewicz, Alana, MD

Get full text

Dementia-Related Agitation in Advanced Dementia: An Evidence-Based Update (504) by Shega, Joseph, MD, Sachs, Greg, MD, Irwin, Scott, MD PhD

Get full text