Search Results - "Irwin, S."

Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group by Irwin, Meredith S, Naranjo, Arlene, Zhang, Fan F, Cohn, Susan L, London, Wendy B, Gastier-Foster, Julie M, Ramirez, Nilsa C, Pfau, Ruthann, Reshmi, Shalini, Wagner, Elizabeth, Nuchtern, Jed, Asgharzadeh, Shahab, Shimada, Hiroyuki, Maris, John M, Bagatell, Rochelle, Park, Julie R, Hogarty, Michael D

“…Treatment planning for children with neuroblastoma requires accurate assessment of prognosis. The most recent Children's Oncology Group (COG) risk…”
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Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis by Seow, C H, Newman, A, Irwin, S P, Steinhart, A H, Silverberg, M S, Greenberg, G R

“…Antibodies to infliximab reduce serum infliximab with loss of clinical benefit, but undetectable trough serum concentrations of infliximab may occur without…”
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A Multicenter Study of ICU Telemedicine Reengineering of Adult Critical Care by Lilly, Craig M., MD, FCCP, McLaughlin, John M., PhD, MSPH, Zhao, Huifang, PhD, Baker, Stephen P., MScPH, Cody, Shawn, RN, MSN, MBA, Irwin, Richard S., MD, Master FCCP

“…Background Few studies have evaluated both the overall effect of ICU telemedicine programs and the effect of individual components of the intervention on…”
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Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project by Sokol, Elizabeth, Desai, Ami V, Applebaum, Mark A, Valteau-Couanet, Dominique, Park, Julie R, Pearson, Andrew D J, Schleiermacher, Gudrun, Irwin, Meredith S, Hogarty, Michael, Naranjo, Arlene, Volchenboum, Samuel, Cohn, Susan L, London, Wendy B

“…The Children's Oncology Group (COG) stratifies the treatment of patients with neuroblastoma on the basis of a combination of biomarkers that include age and…”
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Heterogeneity of MYCN amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasis by Marrano, Paula, Irwin, Meredith S., Thorner, Paul S.

“…Amplification of the MYCN gene in neuroblastoma is associated with a poor prognosis and is considered to remain unchanged in post‐treatment specimens and…”
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Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma by Koneru, Balakrishna, Lopez, Gonzalo, Farooqi, Ahsan, Conkrite, Karina L, Nguyen, Thinh H, Macha, Shawn J, Modi, Apexa, Rokita, Jo Lynne, Urias, Eduardo, Hindle, Ashly, Davidson, Heather, Mccoy, Kristyn, Nance, Jonas, Yazdani, Vanda, Irwin, Meredith S, Yang, Shengping, Wheeler, David A, Maris, John M, Diskin, Sharon J, Reynolds, C Patrick

“…Neuroblastoma is a childhood cancer with heterogeneous clinical outcomes. To comprehensively assess the impact of telomere maintenance mechanism (TMM) on…”
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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation by Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B., Radulovich, Nikolina, Poon, Betty P. K., St-Germain, Jonathan, Cook, Jonathan D., Valencia-Sama, Ivette, Grant, Benjamin M. M., Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S., Lee, Jeffrey E., Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael

“…Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2…”
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Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity by Blanch, Alvaro, Robinson, Fiona, Watson, Ian R, Cheng, Lynn S, Irwin, Meredith S

“…The p53 family of transcription factors is a key regulator of cell proliferation and death. In this report we identify the eukaryotic translation elongation…”
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors by Gebregiworgis, Teklab, Kano, Yoshihito, St-Germain, Jonathan, Radulovich, Nikolina, Udaskin, Molly L., Mentes, Ahmet, Huang, Richard, Poon, Betty P. K., He, Wenguang, Valencia-Sama, Ivette, Robinson, Claire M., Huestis, Melissa, Miao, Jinmin, Yeh, Jen Jen, Zhang, Zhong-Yin, Irwin, Meredith S., Lee, Jeffrey E., Tsao, Ming-Sound, Raught, Brian, Marshall, Christopher B., Ohh, Michael, Ikura, Mitsuhiko

“…Cancer cells bearing distinct KRAS mutations exhibit variable sensitivity to SHP2 inhibitors (SHP2i). Here we show that cells harboring KRAS Q61H are uniquely…”
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Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines by Irwin, Richard S

“…To critically review and summarize the literature on cough and gastroesophageal reflux disease (GERD), and to make evidence-based recommendations regarding the…”
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HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function by Lau, L M S, Nugent, J K, Zhao, X, Irwin, M S

“…Nutlin-3, a small molecule inhibitor, activates p53 by disrupting p53-HDM2 association. In this study, we found that Nutlin-3 suppressed cell growth and…”
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The challenge of defining “ultra‐high‐risk” neuroblastoma by Morgenstern, Daniel A., Bagatell, Rochelle, Cohn, Susan L., Hogarty, Michael D., Maris, John M., Moreno, Lucas, Park, Julie R., Pearson, Andrew D., Schleiermacher, Gudrun, Valteau‐Couanet, Dominique, London, Wendy B., Irwin, Meredith S.

“…Given the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to determining appropriate treatment. Historically, most…”
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Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12- to 18-Month Change in Age Cutoff in Children's Oncology Group Risk Stratification by Bender, Hannah G, Irwin, Meredith S, Hogarty, Michael D, Castleberry, Robert, Maris, John M, Kao, Pei-Chi, Zhang, Fan F, Naranjo, Arlene, Cohn, Susan L, London, Wendy B

“…In 2006, Children's Oncology Group (COG) reclassified subgroups of toddlers diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age…”
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ICU Telemedicine Program Financial Outcomes by Lilly, Craig M., MD, FCCP, Motzkus, Christine, MPH, Rincon, Teresa, RN, BSN, Cody, Shawn E., PhD, MSN/MBA, RN, Landry, Karen, BS, Irwin, Richard S., MD, Master FCCP

“…Background ICU telemedicine improves access to high-quality critical care, has substantial costs, and can change financial outcomes. Detailed information about…”
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Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome by Irwin, Scott A., Galvez, Roberto, Greenough, William T.

“…Fragile-X syndrome is the most common single-gene inherited form of mental retardation. Morphological studies suggest a possible failure of the synapse…”
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Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1 by Wang, Yi, Roche, Olga, Xu, Chaoying, Moriyama, Eduardo H, Heir, Pardeep, Chung, Jacky, Roos, Frederik C, Chen, Yonghong, Finak, Greg, Milosevic, Michael, Wilson, Brian C, Teh, Bin Tean, Park, Morag, Irwin, Meredith S, Ohh, Michael

“…Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and…”
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Effects of Ankle Position While Performing One- and Two-Leg Floor Bridging Exercises on Core and Lower Extremity Muscle Recruitment by Escamilla, Rafael F, Thompson, Irwin S, Carinci, Joe, MacLean, Daniel, MacLean, Lisa, Aguinaldo, Arnel L

“…Given there are no known studies which have examined multiple lower extremity muscles between different ankle positions during bridging activities, the…”
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Prevalence and Test Characteristics of National Health Safety Network Ventilator-Associated Events by Lilly, Craig M, Landry, Karen E, Sood, Rahul N, Dunnington, Cheryl H, Ellison, Richard T, Bagley, Peter H, Baker, Stephen P, Cody, Shawn, Irwin, Richard S

“…OBJECTIVES:The primary aim of the study was to measure the test characteristics of the National Health Safety Network ventilator-associated…”
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Long term outcomes after concurrent ipsilateral nephrectomy versus kidney-sparing surgery for high-risk, intraabdominal neuroblastoma by Fahy, Aodhnait S, Roberts, Amanda, Nasr, Ahmed, Irwin, Meredith S, Gerstle, Justin T

“…The impact of the extent of surgical resection including nephrectomy for high-risk neuroblastoma patients is controversial. In this study, we compared the…”
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Managing unexplained chronic cough in adults: what are the unmet needs? by Irwin, Richard S, French, Cynthia L, Madison, J Mark

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