Search Results - "Irwin, Chris R"

Human odontoblasts express functional thermo-sensitive TRP channels: Implications for dentin sensitivity by El Karim, Ikhlas A., Linden, Gerard J., Curtis, Timothy M., About, Imad, McGahon, Mary K., Irwin, Chris R., Lundy, Fionnuala T.

“…Odontoblasts form the outermost cellular layer of the dental pulp where they have been proposed to act as sensory receptor cells. Despite this suggestion,…”
Get full text

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo by Scott, Aaron, Weldon, Sinéad, Buchanan, Paul J, Schock, Bettina, Ernst, Robert K, McAuley, Danny F, Tunney, Michael M, Irwin, Chris R, Elborn, J Stuart, Taggart, Clifford C

“…Human cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In…”
Get full text

Biodentine Reduces Tumor Necrosis Factor Alpha–induced TRPA1 Expression in Odontoblastlike Cells by El Karim, Ikhlas A., BDS, PhD, McCrudden, Maelíosa T.C., BSc, PhD, McGahon, Mary K., BSc, PhD, Curtis, Tim M., BSc, PhD, Jeanneau, Charlotte, PhD, Giraud, Thomas, DDS, Irwin, Chris R., BSc, BDS, PhD, Linden, Gerard J., BSc, BDS, PhD, Lundy, Fionnuala T., BSc, PhD, About, Imad, MS, PhD

“…Abstract Introduction The transient receptor potential (TRP) ion channels have emerged as important cellular sensors in both neuronal and non-neuronal cells,…”
Get full text

LL-37 in periodontal health and disease and its susceptibility to degradation by proteinases present in gingival crevicular fluid by McCrudden, Maelíosa T. C., Orr, David F., Yu, Yang, Coulter, Wilson A., Manning, Gwen, Irwin, Chris R., Lundy, Fionnuala T.

“…Aim To determine the levels of LL‐37 in and its susceptibility to degradation by components of gingival crevicular fluid (GCF) in periodontal health and…”
Get full text

Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts by El karim, Ikhlas A., BDS, PhD, Linden, Gerard J., BDS, BSc, PhD, Irwin, Chris R., BSc, BDS, PhD, Lundy, Fionnuala T., BSc, PhD

“…Abstract Introduction Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts…”
Get full text

Regulation of HGF and SDF-1 expression by oral fibroblasts – Implications for invasion of oral cancer by Daly, Aisling J, McIlreavey, Leanne, Irwin, Chris R

“…Summary Invasion and metastasis of oral squamous cell carcinoma (OSCC) is dependent on signals received from stromal fibroblasts present in the surrounding…”
Get full text

Effects of LL-37 on Gingival Fibroblasts: A Role in Periodontal Tissue Remodeling? by McCrudden, Maelíosa T C, O'Donnell, Katherine, Irwin, Chris R, Lundy, Fionnuala T

“…Mounting evidence suggests that the host defence peptide, LL-37, plays a role in both inflammation and in wound healing; however, the role of this peptide in…”
Get full text

Substance P Expression by Human Dental Pulp Fibroblasts: A Potential Role in Neurogenic Inflammation by Killough, Simon A., BSc, BDS, MFDS, PhD, Lundy, Fionnuala T., BSc, PhD, Irwin, Chris R., BSc, BDS, FDS (Rest Dent), PhD, FFD

“…Abstract Neurogenic inflammation describes the local release of neuropeptides, notably substance P (SP), from afferent neurons and might play a role in the…”
Get full text

Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression by Shannon, Diane B., McKeown, Scott T.W., Lundy, Fionnuala T., Irwin, Chris R.

“…ABSTRACT Wounds of the oral mucosa heal in an accelerated fashion with reduced scarring compared with cutaneous wounds. The differences in healing outcome…”
Get full text

The cytotoxic effects of human neutrophil peptide-1 (HNP1) and lactoferrin on oral squamous cell carcinoma (OSCC) in vitro by McKeown, Scott T.W., Lundy, Fionnuala T., Nelson, John, Lockhart, Derek, Irwin, Chris R., Cowan, C. Gerard, Marley, John J.

“…α-Defensin or human neutrophil peptide-1 (HNP1) is a neutrophil-derived antimicrobial peptide with cytotoxic effects towards cancer cells. Lactoferrin is also…”
Get full text

The Effects of Cyclosporin on the Collagenolytic Activity of Gingival Fibroblasts by Hyland, Paula L., Traynor, Patrick S., Myrillas, Theofilos T., Marley, John J., Linden, Gerard J., Winter, Paul, Leadbetter, Nicola, Cawston, Timothy E., Irwin, Chris R.

“…Background: The immunosuppressive agent cyclosporin is associated with a number of major side‐effects including the development of gingival overgrowth…”
Get full text

The Role of Soluble Interleukin (IL)‐6 Receptor in Mediating the effects of IL‐6 on Matrix Metalloproteinase‐1 and Tissue Inhibitor of Metalloproteinase‐1 Expression by Gingival Fibroblasts by Irwin, Chris R., Myrillas, Theofilos T., Traynor, Patrick, Leadbetter, Nicola, Cawston, Timothy E.

“…Background: Interleukin‐6 (IL‐6) is a multifunctional cytokine thought to play a role in the tissue destruction that characterizes periodontal disease. IL‐6…”
Get full text

Characterisation of eppin function: expression and activity in the lung by Scott, Aaron, Glasgow, Arlene, Small, Donna, Carlile, Simon, McCrudden, Maelíosa, McLean, Denise, Brown, Ryan, Doherty, Declan, Lundy, Fionnuala T, Hamid, Umar I, O'Kane, Cecilia M, McAuley, Daniel F, Brodlie, Malcolm, Tunney, Michael, Elborn, J Stuart, Irwin, Chris R, Timson, David J, Taggart, Clifford C, Weldon, Sinéad

“…Eppin is a serine protease inhibitor expressed in male reproductive tissues.The aim of this study was to investigate the localisation and regulation of eppin…”
Get full text

Periodontal disease in the older patient by Irwin, Chris R

“…Population projections predict an increasing number of dentate older people who will require assessment and treatment of periodontal disease. Studies show that…”
Get full text

The Host Defence Peptide LL-37 is Susceptible to Proteolytic Degradation by Wound Fluid Isolated from Foot Ulcers of Diabetic Patients by McCrudden, Maelíosa T. C., McLean, Denise T. F., Zhou, Mei, Shaw, Julia, Linden, Gerard J., Irwin, Chris R., Lundy, Fionnuala T.

“…The pleiotropic effects of host defence peptides (HDPs), including the ability to kill microorganisms, enhance re-epithelialisation and increase angiogenesis,…”
Get full text

Chlorhexidine-containing mucoadhesive polymeric compacts designed for use in the oral cavity: an examination of their physical properties, in vitro/in vivo drug release properties and clinical acceptability by Irwin, Chris R, McCullough, Karen C, Jones, David S

“…This study describes the formulation, physicochemical and mucoadhesive properties and in in vitro/in vivo release of chlorhexidine from mucoadhesive, polymeric…”
Get full text

Cyclosporin A Regulates Interleukin‐1ßand Interleukin‐6 Expression in Gingiva: Implications for Gingival Overgrowth by Myrillas, Theofilos T., Linden, Gerard J., Marley, John J., Irwin, Chris R.

“…Background: Gingival overgrowth is a common side effect following the administration of cyclosporin A (CsA); however, the cellular mechanisms remain poorly…”
Get full text

Chlorhexidine-containing mucoadhesive polymeric compacts designed for use in the oral cavity: an examination of their physical properties,\+i\ in vitro\-i\/\+i\ in vivo\-i\ drug release properties and clinical acceptability by Irwin, Chris R, McCullough, Karen C, Jones, David S

“…This study describes the formulation, physicochemical and mucoadhesive properties and in in-vitro/in-vivo release of chlorhexidine from mucoadhesive, polymeric…”
Get full text

Comparative Effects of Cyclosporin on Glycosaminoglycan Synthesis by Gingival Fibroblasts by Newell, Jeff, Irwin, Chris R.

“…Histolotical studies show that drag‐induced gingival overgrowth results from an accumulation of the connective tissue component. Despite comprising a major…”
Get full text

Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth by Hyland, P. L., McKeown, S. T. W., Mackenzie, I. C., Irwin, C. R.

“…Background:  Epithelial proliferation is a histological characteristic of drug‐induced gingival overgrowth. Keratinocyte growth factor (KGF) and scatter factor…”
Get full text