Search Results - "Irwin, C. R."

The neutralising and stimulatory effects of antimicrobial peptide LL-37 in human gingival fibroblasts by Lappin, MJ, Dellett, M., Mills, KI, Lundy, FT, Irwin, CR

“…To investigate the effects of LL-37, a broad spectrum antimicrobial peptide expressed in periodontal tissues, on human gingival fibroblast responsiveness to…”
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The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial by Shaw, J., Hughes, C. M., Lagan, K.M., Stevenson, M. R., Irwin, C.R., Bell, P. M.

“…The aim of the study was to evaluate the effect of topical phenytoin on healing in diabetic foot ulcers. A randomized, controlled, double-blind, clinical trial…”
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PAR-2 Regulates Dental Pulp Inflammation Associated with Caries by Lundy, F.T., About, I., Curtis, T.M., McGahon, M.K., Linden, G.J., Irwin, C.R., El Karim, I.A.

“…Protease-activated receptors (PARs) are G-protein-coupled receptors that are activated enzymatically by proteolysis of an N-terminal domain. The cleavage and…”
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The role of IL-6 in the pathogenesis of periodontal disease by Irwin, CR, Myrillas, TT

“…The mechanisms underlying periodontal disease involve complex interactions between bacterial products, host cells and locally produced, biologically active…”
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Modulation of gingival epithelial phenotypes by interactions with regionally defined populations of fibroblasts by Locke, M., Hyland, P. L., Irwin, C. R., Mackenzie, I. C.

“…Background and Objective:  The unusual structure and functions of junctional epithelium, together with its pattern of migration in periodontal disease, raise…”
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Matrix Metalloproteinase-3 Differences in Oral and Skin Fibroblasts by McKeown, S.T.W., Barnes, J.J., Hyland, P.L., Lundy, F.T., Fray, M.J., Irwin, C.R.

“…While skin wounds heal by scarring, wounds of oral mucosa show privileged healing with minimal scar formation. Our hypothesis was that phenotypic differences…”
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Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease by Jones, David S, Woolfson, A.David, Brown, Andrew F, Coulter, Wilson A, McClelland, Cathy, Irwin, Christopher R

“…This study describes the formulation, characterisation and preliminary clinical evaluation of mucoadhesive, semi-solid formulations containing…”
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Odontoblast cell death induces NLRP3 inflammasome‐dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation by Al Natour, B., Lundy, F. T., Moynah, P. N., About, I., Jeanneau, C., Irwin, C.R., Domberoski, Y., El Karim, I. A.

“…Aim To investigate the ability of dead odontoblasts to initiate NLRP3 inflammasome‐dependent sterile inflammation and to explore the effect on dental pulp cell…”
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Construction of large area organotypical cultures of oral mucosa and skin by Igarashi, M., Irwin, C. R., Locke, M., Mackenzie, I. C.

“…Background:  Skin and oral mucosal keratinocytes grown in vitro usually lose their normal patterns of differentiation, unless grown as organotypical cultures…”
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Matrix metalloproteinase‐8 activity in gingival crevicular fluid: development of a novel assay by Mc Crudden, M. T. C., Irwin, C. R., El karim, I., Linden, G. J., Lundy, F. T.

“…Background and Objective The matrix metalloproteinases (MMPs) play a role in regulating turnover and metabolism of connective tissues in health but they have…”
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Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth by Hyland, P. L., McKeown, S. T. W., Mackenzie, I. C., Irwin, C. R.

“…Background:  Epithelial proliferation is a histological characteristic of drug‐induced gingival overgrowth. Keratinocyte growth factor (KGF) and scatter factor…”
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Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis by Jones, D S, Irwin, C R, Woolfson, A D, Djokic, J, Adams, V

“…In this study, the physicochemical properties and preliminary in vivo clinical performance of formulations containing hydroxyethylcellulose (HEC; 3, 5, 10%…”
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Interferon-γ stimulates CD14, TLR2 and TLR4 mRNA expression in gingival fibroblasts increasing responsiveness to bacterial challenge by Lappin, M.J, Brown, V, Zaric, S.S, Lundy, F.T, Coulter, W.A, Irwin, C.R

“…Highlights • IFN-γ induces mRNA expression of CD14, TLR2 and TLR4 in human gingival fibroblasts. • IFN-γ induces expression of membrane-bound CD14 in human…”
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Gingival fibroblast response to cyclosporin A and transforming growth factor β1 by James, J. A., Irwin, C. R., Linden, G. J.

“…This study investigates a potential role for TGFβ1 in the pathogenesis of cyclosporin A‐induced gingival overgrowth (CsA‐OG). TGFβ1 was localized…”
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Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y by Killough, S. A., Lundy, F. T., Irwin, C. R.

“…Killough SA, Lundy FT, Irwin CR. Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y. International Endodontic Journal, 43,…”
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Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus by James, J. A., Boomer, S., Maxwell, A. P., Hull, P. S., Short, C. D., Campbell, B. A., Johnson, R. W. G., Irwin, C. R., Marley, J. J., Spratt, H., Linden, G. J.

“…Background: Unsightly gingival overgrowth affects many individuals immunosuppressed with cyclosporin A (CsA). Current management involves repeated periodontal…”
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Cyclosporin associated gingival overgrowth in renal transplant recipients by Spratt, H., Boomer, S., Irwin, CR, Marley, JJ, James, JA, Maxwell, P., Middleton, D., Linden, GJ

“…OBJECTIVES: To investigate the prevalence and severity of gingival overgrowth in a group of renal transplant recipients treated in one centre in Northern…”
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The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth by James, J. A., Marley, J. J., Jamal, S., Campbell, B. A., Short, C. D., Johnson, R. W. G., Hull, P. S., Spratt, H., Irwin, C. R., Boomer, S., Maxwell, A. P., Linden, G. J.

“…Background/aims: To investigate whether the choice of calcium channel blocker, used in conjunction with cyclosporin A, affected the prevalence of gingival…”
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Inter- and intra-site heterogeneity in the expression of fetal-like phenotypic characteristics by gingival fibroblasts : potential significance for wound healing by IRWIN, C. R, PICARDO, M, ELLIS, I, SLOAN, P, GREY, A. M, MCGURK, M, SCHOR, S. L

“…We have previously reported that fetal and adult skin fibroblasts display distinctive migratory phenotypes on 3-D collagen substrata and that these behavioural…”
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Subpopulations of fetal-like gingival fibroblasts: characterisation and potential significance for wound healing and the progression of periodontal disease by Schor, S L, Ellis, I, Irwin, C R, Banyard, J, Seneviratne, K, Dolman, C, Gilbert, A D, Chisholm, D M

“…Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the…”
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