Search Results - "Irving, Elaine A"

Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury by Irving, Elaine A., Bamford, Mark

“…Protein kinase-mediated signaling cascades constitute the major route by which cells respond to their extracellular environment. Of these, three…”
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Series: Pragmatic trials and real world evidence: Paper 3. Patient selection challenges and consequences by Oude Rengerink, Katrien, Kalkman, Shona, Collier, Susan, Ciaglia, Antonio, Worsley, Sally D., Lightbourne, Alison, Eckert, Laurent, Groenwold, Rolf H.H., Grobbee, Diederick E., Irving, Elaine A.

“…This paper addresses challenges of identifying, enrolling, and retaining participants in a trial conducted within a routine care setting. All patients who are…”
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The GetReal Trial Tool: design, assess and discuss clinical drug trials in light of Real World Evidence generation by Zuidgeest, Mira G.P., Goetz, Iris, Meinecke, Anna-Katharina, Boateng, Daniel, Irving, Elaine A., van Thiel, Ghislaine J.M., Welsing, Paco M.J., Oude-Rengerink, Katrien, Grobbee, Diederick E.

“…Methodologies incorporating Real World Elements into clinical trial design (also called pragmatic trials) offer an attractive opportunity to assess the effect…”
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Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine by Klyubin, Igor, Wang, Qinwen, Reed, Miranda N, Irving, Elaine A, Upton, Neil, Hofmeister, Jacki, Cleary, James P, Anwyl, Roger, Rowan, Michael J

“…Abstract Soluble amyloid-β protein (Aβ) may cause cognitive impairment in Alzheimer's disease in the absence of significant neurodegeneration. Here, the…”
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Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat by Irving, Elaine A, Barone, Frank C, Reith, Alastair D, Hadingham, Sarah J, Parsons, Andrew A

“…Two relatively well characterised kinase signalling pathways are those involving MAPK/ERK and p38/SAPK2, that are known to be activated in vitro by various…”
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Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex by Strong, Anthony J., Anderson, Peter J., Watts, Helena R., Virley, David J., Lloyd, Andrew, Irving, Elaine A., Nagafuji, Toshiaki, Ninomiya, Mitsuyoshi, Nakamura, Hajime, Dunn, Andrew K., Graf, Rudolf

“…In the light of accumulating evidence for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations in the human brain…”
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Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the rat by Legos, Jeffrey J, Mangoni, Arduino A, Read, Simon J, Campbell, Colin A, Irving, Elaine A, Roberts, Jenny, Barone, Frank C, Parsons, Andrew A

“…Background: Recent studies have demonstrated spontaneous and prolonged hyperthermia following stroke in both humans and rodents. However, a full…”
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SB 234551 selective ETA receptor antagonism : Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection by LEGOS, Jeffrey J, LENHARD, Stephen C, HAIMBACH, Robin E, SCHAEFFER, Thomas R, BENTLEY, Ross G, MCVEY, Matthew J, CHANDRA, Sudeep, IRVING, Elaine A, PARSONS, Andrew A, BARONE, Frank C

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Time-dependent increase in Nogo-A expression after focal cerebral ischemia in marmoset monkeys by Eslamboli, Andisheh, Grundy, Robert I., Irving, Elaine A.

“…Nogo-A is a myelin-associated protein that has been shown to inhibit axonal sprouting after lesions to the CNS. Several studies have demonstrated that blocking…”
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The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase by Takle, Andrew K., Bamford, Mark J., Davies, Susannah, Davis, Robert P., Dean, David K., Gaiba, Alessandra, Irving, Elaine A., King, Frank D., Naylor, Antoinette, Parr, Christopher A., Ray, Alison M., Reith, Alastair D., Smith, Beverley B., Staton, Penelope C., Steadman, Jon G.A., Stean, Tania O., Wilson, David M.

“…Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS…”
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Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? by Irving, Elaine A, Vinson, Mary, Rosin, Claudia, Roberts, Jenny C, Chapman, Debra M, Facci, Laura, Virley, David J, Skaper, Stephen D, Burbidge, Stephen A, Walsh, Frank S, Hunter, A Jacqueline, Parsons, Andrew A

“…The inhibitory activity of myelin-associated glycoprotein (MAG) on neurons is thought to contribute to the lack of regenerative capacity of the CNS after…”
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SB 234551 selective ET A receptor antagonism: Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection by Legos, Jeffrey J., Lenhard, Stephen C., Haimbach, Robin E., Schaeffer, Thomas R., Bentley, Ross G., McVey, Matthew J., Chandra, Sudeep, Irving, Elaine A., Andrew A. Parsons, Barone, Frank C.

“…Mismatches between tissue perfusion-weighted imaging (PWI; an index of blood flow deficit) and cellular diffusion-weighted imaging (DWI; an index of tissue…”
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A selective endothelin ET A receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in rats by Zhang, Yongbo, Belayev, Ludmila, Zhao, Weizhao, Irving, Elaine A., Busto, Raul, Ginsberg, Myron D.

“…In recent experimental studies, a selective antagonist of endothelin ET A receptors, SB 234551, improved neurological and histological outcome in both head…”
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Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: involvement of free radicals by Irving, E A, Yatsushiro, K, McCulloch, J, Dewar, D

“…Glial inclusions containing the microtubule-associated protein tau are present in a variety of chronic neurodegenerative conditions. We now report a rapid and…”
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A selective endothelin ETA receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in rats by YONGBO ZHANG, BELAYEV, Ludmila, WEIZHAO ZHAO, IRVING, Elaine A, BUSTO, Raul, GINSBERG, Myron D

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A novel behavioural registration system LABORAS™ and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat by Quinn, Leann P., Grundy, Robert I., Campbell, Colin A., Collier, Sarah, Lawman, Amanda, Stean, Tania O., Billinton, Andrew, Parsons, Andrew A., Upton, Neil, Duxon, Mark S., Irving, Elaine A.

“…Following stroke, patients suffer a wide range of disabilities including motor impairment, anxiety and depression. However, to date, characterisation of rodent…”
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Participant eligibility, recruitment and retention in pragmatic trials by Oude Rengerink, Katrien, Kalkman, Shona, Collier, Susan, Ciaglia, Antonio, Worsley, Sally D, Lightbourne, Alison, Eckert, Laurent, Groenwold, Rolf H.H, Grobbee, Diederick E, Irving, Elaine A

“…Abstract This paper addresses challenges of identifying, enrolling and retaining participants in a in a trial conducted within a routine care setting. All…”
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SB 234551 selective ET sub(A) receptor antagonism: Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection by Legos, Jeffrey J, Lenhard, Stephen C, Haimbach, Robin E, Schaeffer, Thomas R, Bentley, Ross G, McVey, Matthew J, Chandra, Sudeep, Irving, Elaine A, Parsons, Andrew A, Barone, Frank C

“…Mismatches between tissue perfusion-weighted imaging (PWI; an index of blood flow deficit) and cellular diffusion-weighted imaging (DWI; an index of tissue…”
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Functional recovery and increased PSA-NCAM expression following delayed administration of an anti-MAG antibody post stroke in the rat by Grundy, Robert I, Collier, Sarah, Cambell, Colin A, Wilson, Kevin L, Roberts, Jenny C, Vinson, Mary, Davis, John B, Irving, Elaine A

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P2-019: Effect of gamma-secretase inhibitors dibenzazepine and arylsulphonamide on behaviour and pathology of the gastro-intestinal tract and T lymphocytes of the rat by Vidgeon-Hart, Martin P., Quinn, Leann, Stean, Tania, Marshall, Ian C., Harrison, David C., Burbidge, Stephen A., Irving, Elaine A., Davis, John B., Upton, Neil, Vinson, Mary

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