Search Results - "Irvine, Mark W"

The NMDA receptor as a target for cognitive enhancement by Collingridge, Graham L., Volianskis, Arturas, Bannister, Neil, France, Grace, Hanna, Lydia, Mercier, Marion, Tidball, Patrick, Fang, Guangyu, Irvine, Mark W., Costa, Blaise M., Monaghan, Daniel T., Bortolotto, Zuner A., Molnár, Elek, Lodge, David, Jane, David E.

“…NMDA receptors (NMDARs) play an important role in neural plasticity including long-term potentiation and long-term depression, which are likely to explain…”
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Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators by Monaghan, Daniel T., Irvine, Mark W., Costa, Blaise Mathias, Fang, Guangyu, Jane, David E.

“…[Display omitted] ► There are now several pharmacological sites on the NMDA receptor complex. ► Positive and negative allosteric modulators of NMDA receptors…”
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors by Wang, Jue Xiang, Irvine, Mark W., Burnell, Erica S., Sapkota, Kiran, Thatcher, Robert J., Li, Minjun, Simorowski, Noriko, Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E., Furukawa, Hiro

“…N -Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct…”
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Different NMDA receptor subtypes mediate induction of long‐term potentiation and two forms of short‐term potentiation at CA1 synapses in rat hippocampus in vitro by Volianskis, Arturas, Bannister, Neil, Collett, Valerie J., Irvine, Mark W., Monaghan, Daniel T., Fitzjohn, Stephen M., Jensen, Morten S., Jane, David E., Collingridge, Graham L.

“…Key points N‐Methyl‐d‐aspartate receptor (NMDAR)‐dependent potentiation of synaptic transmission is widely accepted as a cellular model of learning and memory…”
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A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors by Chopra, Divyan A., Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Jane, David E., Monaghan, Daniel T., Dravid, Shashank M.

“…NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified…”
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N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse by Costa, Blaise Mathias, Feng, Bihua, Tsintsadze, Timur S, Morley, Richard M, Irvine, Mark W, Tsintsadze, Vera, Lozovaya, Natasha A, Jane, David E, Monaghan, Daniel T

“…N-Methyl-d-aspartate (NMDA) receptor antagonists that are highly selective for specific NMDA receptor 2 (NR2) subunits have several potential therapeutic…”
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Piperazine-2,3-dicarboxylic Acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors by Irvine, Mark W, Costa, Blaise M, Dlaboga, Daniel, Culley, Georgia R, Hulse, Richard, Scholefield, Caroline L, Atlason, Palmi, Fang, Guangyu, Eaves, Richard, Morley, Richard, Mayo-Martin, Maria B, Amici, Mascia, Bortolotto, Zuner A, Donaldson, Lucy, Collingridge, Graham L, Molnár, Elek, Monaghan, Daniel T, Jane, David E

“…Competitive N-methyl-d-aspartate receptor (NMDAR) antagonists bind to the GluN2 subunit, of which there are four types (GluN2A-D). We report that some…”
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Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792 by Sapkota, Kiran, Burnell, Erica S., Irvine, Mark W., Fang, Guangyu, Gawande, Dinesh Y., Dravid, Shashank M., Jane, David E., Monaghan, Daniel T.

“…N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR…”
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Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus by France, Grace, Fernández-Fernández, Diego, Burnell, Erica S., Irvine, Mark W., Monaghan, Daniel T., Jane, David E., Bortolotto, Zuner A., Collingridge, Graham L., Volianskis, Arturas

“…In the CA1 area of the hippocampus N-methyl-d-aspartate receptors (NMDARs) mediate the induction of long-term depression (LTD), short-term potentiation (STP)…”
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A novel family of negative and positive allosteric modulators of NMDA receptors by Costa, Blaise Mathias, Irvine, Mark W, Fang, Guangyu, Eaves, Richard J, Mayo-Martin, Marie Belen, Skifter, Donald A, Jane, David E, Monaghan, Daniel T

“…The N-methyl-D-aspartate (NMDA) receptor family regulates various central nervous system functions, such as synaptic plasticity. However, hypo- or…”
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Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid by Irvine, Mark W., Fang, Guangyu, Sapkota, Kiran, Burnell, Erica S., Volianskis, Arturas, Costa, Blaise M., Culley, Georgia, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.

“…The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-glutamate and glycine, plays a major role in the synaptic plasticity…”
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The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site by Safar, Fatemah, Hurdiss, Elliot, Erotocritou, Marios, Greiner, Timo, Lape, Remigijus, Irvine, Mark W., Fang, Guangyu, Jane, David, Yu, Rilei, Dämgen, Marc A., Biggin, Philip C., Sivilotti, Lucia G.

“…Glycine receptors (GlyR) belong to the pentameric ligand-gated ion channel (pLGIC) superfamily and mediate fast inhibitory transmission in the vertebrate CNS…”
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Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives by Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Burnell, Erica S., Bannister, Neil, Volianskis, Arturas, Culley, Georgia R., Dravid, Shashank M., Collingridge, Graham L., Jane, David E., Monaghan, Daniel T.

“…The theory that N-methyl-d-aspartate receptor (NMDAR) hypofunction is responsible for the symptoms of schizophrenia is well supported by many pharmacological…”
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Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid by Costa, Blaise Mathias, Irvine, Mark W., Fang, Guangyu, Eaves, Richard J., Mayo-Martin, Maria Belen, Laube, Bodo, Jane, David E., Monaghan, Daniel T.

“…Over-activation of N-methyl-d-aspartate (NMDA) receptors is critically involved in many neurological conditions, thus there has been considerable interest in…”
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Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors by Irvine, Mark W., Costa, Blaise M., Volianskis, Arturas, Fang, Guangyu, Ceolin, Laura, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.

“…► Coumarins based on the negative allosteric modulator UBP608 inhibit cloned NMDARs. ► 6,8-Dibromo- and 6,8-diiodo-coumarin-3-carboxylate were the most potent…”
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An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo by Wallis, James L., Irvine, Mark W., Jane, David E., Lodge, David, Collingridge, Graham L., Bortolotto, Zuner A.

“…ABSTRACT The roles of both kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) in mossy fiber long‐term potentiation (MF‐LTP) have been…”
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Rhodanine derivatives as novel inhibitors of PDE4 by Irvine, Mark W., Patrick, Graham L., Kewney, Justin, Hastings, Stuart F., MacKenzie, Simon J.

“…The discovery, synthesis and in-vitro activity of a novel series of rhodanine based phosphodiesterase-4 inhibitors (e.g. 3i) is described. The discovery,…”
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Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators: The Glutamatergic Synapse by MONAGHAN, Daniel T, IRVINE, Mark W, MATHIAS COSTA, Blaise, GUANGYU FANG, JANE, David E

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Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors: The Glutamatergic Synapse by IRVINE, Mark W, COSTA, Blaise M, VOLIANSKIS, Arturas, GUANGYU FANG, CEOLIN, Laura, COLLINGRIDGE, Graham L, MONAGHAN, Daniel T, JANE, David E

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Sex, lies and politics: the psychoanalytic transition of the ideological word in mario vargas llosa's peruvian novels by Irvine, Mark W

“…Using psychoanalytic literary criticism based around the theories of Sigmund Freud, Jacques Lacan and Julia Kristeva, this thesis will show how the…”
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