Search Results - "Irvine, Frano"

1131 Anti-CLEC2D-TLR9 agonist conjugate binds to and internalizes CLEC2D on myeloid cells, plasmacytoid DCs and B cells leading to robust TLR pathway activation and inflammatory cytokine production by Tabrizi, Siamak, Nandivada, Vandana, Irvine, Frano, Goshert, Caitlin, Nichols, Kelly, Scanlon, Elizabeth, Huggins, Matthew, Flick, Heather, Tang, Ming, Tan, Seng-Lai, Wang, Xianzhe, Malu, Shruti

“…BackgroundCurrent immunotherapies fail to provide benefit to tumors poorly infiltrated with T and NK cells. However, activation of myeloid cells and B cells…”
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Anti CD161 Antibody IMT-009 Is a Novel Immunotherapeutic Agent That Effectively Blocks the Inhibitory CLEC2D/CD161 Axis in CLEC2D+ B Cell Hematological Malignancies Reinvigorating T and NK Cell Function Leading to Anti-Tumor Benefit by Bernstein, Matthew, Scanlon, Elizabeth, Fusco, Alexandria, Irvine, Frano, Brown, Flavian D, Colbert, Jeffrey D, Huggins, Matthew A, Ross, Michael, Tang, Ming, Malu, Shruti

“…Background: The CLEC2D/CD161 axis is a ligand-receptor pathway that has been shown to inhibit both T and NK cell function 1,2. CD161 is a C-type lectin-like…”
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