Search Results - "Irvine, Darrell"

Controlling timing and location in vaccines by Irvine, Darrell J., Aung, Aereas, Silva, Murillo

“…Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate…”
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Delivering safer immunotherapies for cancer by Milling, Lauren, Zhang, Yuan, Irvine, Darrell J.

“…Cancer immunotherapy is now a powerful clinical reality, with a steady progression of new drug approvals and a massive pipeline of additional treatments in…”
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Enhancing cancer immunotherapy with nanomedicine by Irvine, Darrell J., Dane, Eric L.

“…Therapeutic targeting of the immune system in cancer is now a clinical reality and marked successes have been achieved, most notably through the use of…”
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Synthetic Nanoparticles for Vaccines and Immunotherapy by Irvine, Darrell J, Hanson, Melissa C, Rakhra, Kavya, Tokatlian, Talar

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Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants by Bhagchandani, Sachin, Johnson, Jeremiah A., Irvine, Darrell J.

“…[Display omitted] Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists of Toll-like receptors 7 and 8 (TLR7/8) and one is…”
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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity by Zhang, Yuan, Li, Na, Suh, Heikyung, Irvine, Darrell J.

“…Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)−2 generate effective anti-tumor immunity but also elicit serious toxicities,…”
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Shaping humoral immunity to vaccines through antigen-displaying nanoparticles by Irvine, Darrell J, Read, Benjamin J

“…Strategies to qualitatively and quantitatively enhance the humoral response to immunizations with protein and polysaccharide antigens are of broad interest for…”
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Drug delivery: One nanoparticle, one kill by Irvine, Darrell J

“…By wrapping a ligand-functionalized lipid membrane around a silica core, nanoparticles with a fluid surface are created. These combine unprecedented…”
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Beyond antigens and adjuvants: formulating future vaccines by Moyer, Tyson J, Zmolek, Andrew C, Irvine, Darrell J

“…The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when,…”
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Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines by Aung, Aereas, Irvine, Darrell J

“…Primary immune responses following vaccination are initiated in draining lymph nodes, where naive T and B cells encounter Ag and undergo coordinated steps of…”
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Engineering synthetic vaccines using cues from natural immunity by Irvine, Darrell J., Swartz, Melody A., Szeto, Gregory L.

“…The clinical application of vaccines has expanded from infectious diseases to cancer, enhancing our vision of how the immune system can be used to prevent and…”
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Roles for Innate Immunity in Combination Immunotherapies by Moynihan, Kelly D, Irvine, Darrell J

“…Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory…”
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A mobile home for T cells by Lei, Kewen, Irvine, Darrell J.

“…Lyophilized lymph nodes are a natural scaffold to deliver chimeric antigen receptor (CAR) T cells to tumour resection sites, where they serve as a natural T…”
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Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors by Zheng, Yiran, Tang, Li, Mabardi, Llian, Kumari, Sudha, Irvine, Darrell J

“…Adoptive cell therapy (ACT) has achieved striking efficacy in B-cell leukemias, but less success treating other cancers, in part due to the rapid loss of ACT…”
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Bio-inspired, bioengineered and biomimetic drug delivery carriers by Mitragotri, Samir, Yoo, Jin-Wook, Irvine, Darrell J, Discher, Dennis E

“…Key Points There are various challenges and limitations associated with the delivery of free drugs. These include poor solubility, poor stability, unwanted…”
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Engineering Nano- and Microparticles to Tune Immunity by Moon, James J., Huang, Bonnie, Irvine, Darrell J.

“…The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue…”
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Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications by Liu, Haipeng, Irvine, Darrell J.

“…Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated…”
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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo by Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane

“…How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to…”
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Structure-based programming of lymph-node targeting in molecular vaccines by Liu, Haipeng, Moynihan, Kelly D., Zheng, Yiran, Szeto, Gregory L., Li, Adrienne V., Huang, Bonnie, Van Egeren, Debra S., Park, Clara, Irvine, Darrell J.

“…An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by…”
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Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy by Fan, Yuchen, Kuai, Rui, Xu, Yao, Ochyl, Lukasz J, Irvine, Darrell J, Moon, James J

“…Despite their potential, conventional whole-cell cancer vaccines prepared by freeze–thawing or irradiation have shown limited therapeutic efficacy in clinical…”
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