Search Results - "Irvine, A. D."

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity by Kezic, S., O’Regan, G. M., Yau, N., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Irwin McLean, W. H., Irvine, A. D.

“…To cite this article: Kezic S, O’Regan GM, Yau N, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Irwin McLean WH, Irvine AD. Levels of…”
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The role of filaggrin in the atopic diathesis by O'Regan, G. M., Irvine, A. D.

“…Summary Atopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions, immunodysregulation, disrupted epidermal barrier function and…”
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Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis by McAleer, M.A., Jakasa, I., Hurault, G., Sarvari, P., McLean, W.H.I., Tanaka, R.J., Kezic, S., Irvine, A.D.

“…Summary Background Biomarkers of atopic dermatitis (AD) are largely lacking, especially in infant AD. Those that have been examined to date have focused mostly…”
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Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide by Irvine, A.D., Mina‐Osorio, P.

“…Summary Background Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates…”
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Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement by Drucker, A.M., Eyerich, K., de Bruin‐Weller, M.S., Thyssen, J.P., Spuls, P.I., Irvine, A.D., Girolomoni, G., Dhar, S., Flohr, C., Murrell, D.F., Paller, A.S., Guttman‐Yassky, E.

“…Summary Background Guidelines discourage the use of systemic corticosteroids for atopic dermatitis (AD), but their use remains widespread. Objectives To reach…”
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The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group by Alexander, H., Paller, A.S., Traidl‐Hoffmann, C., Beck, L.A., De Benedetto, A., Dhar, S., Girolomoni, G., Irvine, A.D., Spuls, P., Su, J., Thyssen, J.P., Vestergaard, C., Werfel, T., Wollenberg, A., Deleuran, M., Flohr, C.

“…Summary Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections, which cause significant morbidity and, if untreated, may…”
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Early‐life regional and temporal variation in filaggrin‐derived natural moisturizing factor, filaggrin‐processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis by McAleer, M.A., Jakasa, I., Raj, N., O'Donnell, C.P.F., Lane, M.E., Rawlings, A.V., Voegeli, R., McLean, W.H.I., Kezic, S., Irvine, A.D.

“…Summary Background Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and…”
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The European TREatment of ATopic eczema (TREAT) Registry Taskforce survey: prescribing practices in Europe for phototherapy and systemic therapy in adult patients with moderate‐to‐severe atopic eczema by Vermeulen, F.M., Gerbens, L.A.A., Schmitt, J., Deleuran, M., Irvine, A.D., Logan, K., Ouwerkerk, W., Vestergaard, C., Flohr, C., Spuls, P.I.

“…Summary Background For many years dermatologists have had access to few therapies for patients with moderate‐to‐severe atopic eczema (AE). New promising…”
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Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort by Mulick, A.R., Mansfield, K.E., Silverwood, R.J., Budu‐Aggrey, A., Roberts, A., Custovic, A., Pearce, N., Irvine, A.D., Smeeth, L., Abuabara, K., Langan, S.M.

“…Summary Background Atopic dermatitis (AD) disease activity and severity is highly variable during childhood. Early attempts to identify subtypes based on…”
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MicroRNA analysis of childhood atopic dermatitis reveals a role for miR‐451a by Nousbeck, J., McAleer, M.A., Hurault, G., Kenny, E., Harte, K., Kezic, S., Tanaka, R.J., Irvine, A.D.

“…Summary Background MicroRNAs (miRNAs), important regulators of gene expression, have been implicated in a variety of disorders. The expression pattern of…”
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The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis by Harkins, C.P., McAleer, M.A., Bennett, D., McHugh, M., Fleury, O.M., Pettigrew, K.A., Oravcová, K., Parkhill, J., Proby, C.M., Dawe, R.S., Geoghegan, J.A., Irvine, A.D., Holden, M.T.G.

“…Summary Background Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during…”
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Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations by Chen, H., Common, J.E.A., Haines, R.L., Balakrishnan, A., Brown, S.J., Goh, C.S.M., Cordell, H.J., Sandilands, A., Campbell, L.E., Kroboth, K., Irvine, A.D., Goh, D.L.M., Tang, M.B.Y., van Bever, H.P., Giam, Y.C., McLean, W.H.I., Lane, E.B.

“…Summary Background  Null mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and predispose to atopic dermatitis (AD). Cohort studies in…”
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What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review by Blakeway, H., Van‐de-Velde, V., Allen, V.B., Kravvas, G., Palla, L., Page, M.J., Flohr, C., Weller, R.B., Irvine, A.D., McPherson, T., Roberts, A., Williams, H.C., Reynolds, N., Brown, S.J., Paternoster, L., Langan, S.M.

“…Summary Background Epidemiological studies indicate that gene–environment interactions play a role in atopic dermatitis (AD). Objectives To review the evidence…”
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TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries by Vermeulen, F.M., Gerbens, L.A.A., Bosma, A.L., Apfelbacher, C.J., Irvine, A.D., Arents, B.W.M., Barbarot, S., Deleuran, M., Eichenfield, L.F., Manca, A., Schmitt, J., Vestergaard, C., Wall, D., Weidinger, S., Middelkamp‐Hup, M.A., Spuls, P.I., Flohr, C.

“…Summary Background Comparative, real‐life and long‐term evidence on the effectiveness and safety of phototherapy and systemic therapy in moderate‐to‐severe…”
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TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo‐ and systemic therapy registries by Gerbens, L.A.A., Apfelbacher, C.J., Irvine, A.D., Barbarot, S., Booij, R.J., Boyce, A.E., Deleuran, M., Eichenfield, L.F., Hof, M.H., Middelkamp‐Hup, M.A., Roberts, A., Schmitt, J., Vestergaard, C., Wall, D., Weidinger, S., Williamson, P.R., Flohr, C., Spuls, P.I.

“…Summary Background Evidence of immunomodulatory therapies to guide clinical management of atopic eczema (AE) is scarce, despite frequent and often off‐label…”
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Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation by Irvine, A D, Mclean, W H I

“…Keratins are obligate heterodimer proteins that form the intermediate filament cytoskeleton of all epithelial cells. Keratins are tissue and differentiation…”
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Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations by Onoufriadis, A., Cabezas, A., Ng, J.C.F., Canales, J., Costas, M.J., Ribeiro, J.M., Rodrigues, J.R., McAleer, M.A., Castelo‐Soccio, L., Simpson, M.A., Fraternali, F., Irvine, A.D., Cameselle, J.C., McGrath, J.A.

“…Summary Background Loose anagen hair is a rare form of impaired hair anchorage in which anagen hairs that lack inner and outer root sheaths can be gently and…”
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Global reporting of cases of COVID‐19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic by Mahil, S.K., Yiu, Z.Z.N., Mason, K.J., Dand, N., Coker, B., Wall, D., Fletcher, G., Bosma, A., Capon, F., Iversen, L., Langan, S.M., Di Meglio, P., Musters, A.H., Prieto‐Merino, D., Tsakok, T., Warren, R.B., Flohr, C., Spuls, P.I., Griffiths, C.E.M., Barker, J., Irvine, A.D., Smith, C.H.

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Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening by Lovgren, M.‐L., McAleer, M.A., Irvine, A.D., Wilson, N.J., Tavadia, S., Schwartz, M.E., Cole, C., Sandilands, A., Smith, F.J.D., Zamiri, M.

“…Summary The inherited palmoplantar keratodermas (PPKs) are a heterogeneous group of genodermatoses, characterized by thickening of the epidermis of the palms…”
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Dermatological manifestations of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP): a case series of 28 patients by Chasseuil, E., McGrath, J.A., Seo, A., Balguerie, X., Bodak, N., Chasseuil, H., Denis‐Musquer, M., Goldenberg, A., Goussot, R., Irvine, A.D., Khumalo, N.P., King, M.C., Küry, S., Lipsker, D., Mallet, S., Mayosi, B.M., Nanda, A., Puzenat, E., Salort‐Campana, E., Sidbury, R., Shimamura, A., Bézieau, S., Mercier, S., Barbarot, S.

“…Dear Editor, Hereditary Fibrosing Poikiloderma with Tendon Contractures, Myopathy and Pulmonary Fibrosis (POIKTMP [MIM 615704]) is a recently described…”
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