Kinetics of the Inflammatory Response in Subcutaneous Cysticercosis Induced in Mice by Taenia crassiceps

The larval stage of Taenia crassiceps has been used to study human cysticercosis as these larvae have antigenic similarity to the cysticerci of Taenia solium. The aim of this study was to evaluate the histopathological and immunological changes that followed the inoculation of T. crassiceps cysticer...

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Bibliographic Details
Published in:	Journal of comparative pathology Vol. 147; no. 2-3; pp. 267 - 274
Main Authors:	Freitas, A.A., Moura, V.B.L., Gonçalves, S.F., Rodrigues, A.A., Félix, R.M., Soares, T.P., Irusta, V.R.C., Vinaud, M.C., Oliveira, M.A.P., Lino-Junior, R.S.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2012
Subjects:	Animals Cysticercosis - blood Cysticercosis - immunology Cysticercosis - pathology Disease Models, Animal experimental cysticercosis Granuloma - blood Granuloma - immunology Granuloma - pathology granulomatous inflammation Host-Parasite Interactions - physiology immune response Interferon-gamma - blood Interleukin-4 - blood Macrophages - immunology Macrophages - pathology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophils - metabolism Neutrophils - pathology Parasitic Diseases, Animal - blood Parasitic Diseases, Animal - immunology Parasitic Diseases, Animal - pathology subcutaneous cysticercosis Subcutaneous Tissue - immunology Subcutaneous Tissue - parasitology Subcutaneous Tissue - pathology Time Factors subcutaneous cysticercosis granulomatous inflammation immune response experimental cysticercosis
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Summary:	The larval stage of Taenia crassiceps has been used to study human cysticercosis as these larvae have antigenic similarity to the cysticerci of Taenia solium. The aim of this study was to evaluate the histopathological and immunological changes that followed the inoculation of T. crassiceps cysticerci into the subcutaneous tissue of C57BL/6 mice. Microscopically, granulomas formed of neutrophils and macrophages developed at the sites of inoculation. The serum concentration of the cytokine interferon (IFN)-γ increased throughout the course of infection, while the serum concentration of interleukin-4 increased during the period of transition from the initial phase (7–30days postinoculation [dpi]) to the late phase (60–90dpi) of infection. Destruction of the parasite therefore appears to be associated with an increase in IFN-γ, suggesting that a type 1 immune response is important in the control of the parasite.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9975 1532-3129
DOI:	10.1016/j.jcpa.2011.12.009