Search Results - "Irusta, Pablo M."

Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease by Polack, Fernando P, Delgado, Maria Florencia, Coviello, Silvina, Monsalvo, A Clara, Melendi, Guillermina A, Hernandez, Johanna Zea, Batalle, Juan P, Diaz, Leandro, Trento, Alfonsina, Chang, Herng-Yu, Mitzner, Wayne, Ravetch, Jeffrey, Melero, José A, Irusta, Pablo M

“…A formalin-inactivated vaccine from the 1960s against respiratory syncytial virus (RSV) failed to protect children. Although scientists thought that its…”
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Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro by de Cabo, Rafael, Liu, Lijuan, Ali, Ahmed, Price, Nathan, Zhang, Jing, Wang, Mingyi, Lakatta, Edward, Irusta, Pablo M

“…The cumulative effects of cellular senescence and cell loss over time in various tissues and organs are considered major contributing factors to the ageing…”
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The role of protease-activated receptor 1 signaling in CD8 T cell effector functions by Chen, Hui, Smith, Mindy, Herz, Jasmin, Li, Tong, Hasley, Rebecca, Le Saout, Cecile, Zhu, Ziang, Cheng, Jie, Gronda, Andres, Martina, José A., Irusta, Pablo M., Karpova, Tatiana, McGavern, Dorian B., Catalfamo, Marta

“…CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role…”
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Mitochondrial biogenesis and healthy aging by López-Lluch, Guillermo, Irusta, Pablo M., Navas, Placido, de Cabo, Rafael

“…Aging is associated with an overall loss of function at the level of the whole organism that has origins in cellular deterioration. Most cellular components,…”
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The Cysteine-Rich Region of Respiratory Syncytial Virus Attachment Protein Inhibits Innate Immunity Elicited by the Virus and Endotoxin by Polack, Fernando P., Irusta, Pablo M., Hoffman, Scott J., Schiatti, M. Paula, Melendi, Guillermina A., Delgado, M. Florencia, Laham, Federico R., Thumar, Bhagvanji, Hendry, R. Michael, Melero, Jose A., Karron, Ruth A., Collins, Peter L., Kleeberger, Steven R., Lamb, Robert A.

“…The attachment protein (glycoprotein) of respiratory syncytial virus (RSV) has long been associated with disease potentiation and respiratory symptoms. The…”
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IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells by Acacia de Sa Pinheiro, Ana, Morrot, Alexandre, Chakravarty, Sumana, Overstreet, Michael, Bream, Jay H., Irusta, Pablo M., Zavala, Fidel

“…IL‐4 has distinct effects on the differentiation and functional properties of CD8+ T cells. In vivo studies have shown that it is critical for the development…”
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Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export by Esmaili, Armond M., Johnson, Erika L., Thaivalappil, Silpa S., Kuhn, Helena M., Kornbluth, Sally, Irusta, Pablo M.

“…Aven is a regulator of apoptosis whose overexpression is associated with poor prognosis in several cancers, including childhood acute lymphoblastic leukemia…”
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SRT1720 improves survival and healthspan of obese mice by Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael

“…Sirt1 is an NAD + -dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in…”
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C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression by MELENDI, Guillermina A, HOFLMAN, Scott J, THUMAR, Adeep, GERARD, Norma P, MITZNER, Wayne, BARNUM, Scott R, GERARD, Craig, KLEEBERGER, Steven R, POLACK, Fernando P, KARRON, Ruth A, IRUSTA, Pablo M, LAHAM, Federico R, HUMBLES, Alison, SCHOFIELD, Brian, PAN, Chien-Hsiung, RABOLD, Richard, THUMAR, Bhagvanji

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Viral modulators of cell death provide new links to old pathways by Irusta, Pablo M, Chen, Ying-bei, Hardwick, J Marie

“…By observing how viruses facilitate their parasitic relationships with host cells, we gain insights into key regulatory pathways of the cell. Not only are…”
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Bacterial lysates improve the protective antibody response against respiratory viruses through Toll-like receptor 4 by Coviello, Silvina, Wimmenauer, Vera, Polack, Fernando P, Irusta, Pablo M

“…Respiratory viruses cause significant morbidity and mortality in infants and young children worldwide. Current strategies to modulate the immune system and…”
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Aven-Dependent Activation of ATM Following DNA Damage by Guo, Jessie Yanxiang, Yamada, Ayumi, Kajino, Taisuke, Wu, Judy Qiju, Tang, Wanli, Freel, Christopher D., Feng, Junjie, Chau, B. Nelson, Wang, Michael Zhuo, Margolis, Seth S., Yoo, Hae Yong, Wang, Xiao-Fan, Dunphy, William G., Irusta, Pablo M., Hardwick, J. Marie, Kornbluth, Sally

“…In response to DNA damage, cells undergo either cell-cycle arrest or apoptosis, depending on the extent of damage and the cell's capacity for DNA repair…”
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Reply to: "Antibody affinity maturation and respiratory syncytial virus disease" by Polack, Fernando P, Florencia Delgado, Maria, Irusta, Pablo M

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Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven: Identification of Drosophila Aven by Zou, Sige, Chang, Joy, LaFever, Leesa, Tang, Wangli, Johnson, Erika L., Hu, Jack, Wilk, Ronit, Krause, Henry M., Drummond-Barbosa, Daniela, Irusta, Pablo M.

“…Aven is a regulator of the DNA-damage response and G 2 /M cell cycle progression. Overexpression of Aven is associated with poor prognosis in patients with…”
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Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responses by Melendi, Guillermina A, Bridget, Dowd, Monsalvo, Ana C, Laham, Federico F, Acosta, Patricio, Delgado, Maria Florencia, Polack, Fernando P, Irusta, Pablo M

“…The cytotoxic T-lymphocyte (CTL) response plays an important role in the control of respiratory syncytial virus (RSV) replication and the establishment of a…”
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Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice by Birkenfeld, Andreas L., Lee, Hui-Young, Guebre-Egziabher, Fitsum, Alves, Tiago C., Jurczak, Michael J., Jornayvaz, Francois R., Zhang, Dongyang, Hsiao, Jennifer J., Martin-Montalvo, Alejandro, Fischer-Rosinsky, Antje, Spranger, Joachim, Pfeiffer, Andreas F., Jordan, Jens, Fromm, Martin F., König, Jörg, Lieske, Stefanie, Carmean, Christopher M., Frederick, David W., Weismann, Dirk, Knauf, Felix, Irusta, Pablo M., De Cabo, Rafael, Helfand, Stephen L., Samuel, Varman T., Shulman, Gerald I.

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Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper by Colón-Ramos, Daniel A, Irusta, Pablo M, Gan, Eugene C, Olson, Michael R, Song, Jaewhan, Morimoto, Richard I, Elliott, Richard M, Lombard, Mark, Hollingsworth, Robert, Hardwick, J Marie, Smith, Gary K, Kornbluth, Sally

“…Members of the California serogroup of bunyaviruses (family Bunyaviridae) are the leading cause of pediatric viral encephalitis in North America. Significant…”
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Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven by Zou, Sige, Chang, Joy, LaFever, Leesa, Tang, Wangli, Johnson, Erika L, Hu, Jack, Wilk, Ronit, Krause, Henry M, Drummond-Barbosa, Daniela, Irusta, Pablo M

“…Aven is a regulator of the DNA-damage response and G2/M cell cycle progression. Overexpression of Aven is associated with poor prognosis in patients with…”
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Definition of an Inhibitory Juxtamembrane WW-like Domain in the Platelet-derived Growth Factor β Receptor by Irusta, Pablo M., Luo, Yue, Bakht, Omar, Lai, Char-Chang, Smith, Steven O., DiMaio, Daniel

“…A variety of tumors contain activating mutations in the cytoplasmic juxtamembrane domain of the type III family of receptor-tyrosine kinases, and some…”
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A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation by Irusta, Pablo M., DiMaio, Daniel

“…Platelet‐derived growth factor β receptor (PDGFβR) is a transmembrane receptor tyrosine kinase involved in a variety of cellular functions. We have generated a…”
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