Search Results - "Irtenkauf, Susan"

Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic Differentiation by Berezovsky, Artem D, Poisson, Laila M, Cherba, David, Webb, Craig P, Transou, Andrea D, Lemke, Nancy W, Hong, Xin, Hasselbach, Laura A, Irtenkauf, Susan M, Mikkelsen, Tom, deCarvalho, Ana C

“…Abstract The high-mobility group–box transcription factor sex-determining region Y–box 2 (Sox2) is essential for the maintenance of stem cells from early…”
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Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research by Irtenkauf, Susan M, Sobiechowski, Susan, Hasselbach, Laura A, Nelson, Kevin K, Transou, Andrea D, Carlton, Enoch T, Mikkelsen, Tom, deCarvalho, Ana C

“…Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panel of patient-derived mouse orthotopic…”
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Optimization of high grade glioma cell culture from surgical specimens for use in clinically relevant animal models and 3D immunochemistry by Hasselbach, Laura A, Irtenkauf, Susan M, Lemke, Nancy W, Nelson, Kevin K, Berezovsky, Artem D, Carlton, Enoch T, Transou, Andrea D, Mikkelsen, Tom, deCarvalho, Ana C

“…Glioblastomas, the most common and aggressive form of astrocytoma, are refractory to therapy, and molecularly heterogeneous. The ability to establish cell…”
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The impact of initial tumor microenvironment on imaging phenotype by Nagaraja, Tavarekere N., deCarvalho, Ana C., Brown, Stephen L., Griffith, Brent, Farmer, Katelynn, Irtenkauf, Susan, Hasselbach, Laura, Mukherjee, Abir, Bartlett, Seamus, Valadie, O. Grahm, Cabral, Glauber, Knight, Robert A., Lee, Ian Y., Divine, George W., Ewing, James R.

“…•Most available murine models of glioblastoma (GBM) do not reproduce radiologic features of the human disease i.e., a space-occupying tumor and T1 contrast…”
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Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: A high-resolution magnetic resonance spectroscopy study by O'Leary-Moore, Shonagh K, Galloway, Matthew P, McMechan, Andrew P, Irtenkauf, Susan, Hannigan, John H, Bowen, Scott E

“…Abstract Inhalant abuse in young people is a growing public health concern. We reported previously that acute toluene intoxication in young rats, using a…”
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EXTH-06. GLIOBLASTOMA PATIENT SPECIFIC TRANSCRIPTOME REMODELING IN RESPONSE TO MDM2 ANTAGONIST TREATMENT OF WILD-TYPE P53 CANCER STEM CELLS IS ASSOCIATED WITH SENSITIVITY AND STRATEGIES FOR COMBINATION THERAPY by Meng, Yuling, Mughal, Nouman, Datta, Indrani, Nuga, Oluwademilade, Irtenkauf, Susan, Hasselbach, Laura, Quenneville, Kristyn, Brown, Stephen, deCarvalho, Ana

“…Abstract Over 70% of glioblastomas are p53 wild-type and these patients could benefit from p53 reactivation treatment. Here we determined the sensitivity of a…”
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CSIG-10. PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA ONCOGENE DEPENDENCY IN GLIOBLASTOMA by Berezovsky, Artem, Datta, Indrani, She, Ruicong, Transou, Andrea, Irtenkauf, Susan, Hasselbach, Laura, Poisson, Laila, deCarvalho, Ana

“…Abstract PDGFRA is the second most frequently amplified gene encoding receptor tyrosine kinase in adult glioblastoma (GBM), oftentimes as extrachromosomal…”
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CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA by Berezovsky, Artem, Irtenkauf, Susan, Transou, Andrea, Hasselbach, Laura, Mikkelsen, Tom, de Carvalho, Ana

“…Abstract Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential…”
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Abstract 1505: Platelet derived growth factor receptor alpha oncogene dependency in glioblastoma by Berezovsky, Artem D., Irtenkauf, Susan M., Transou, Andrea D., Hasselbach, Laura A., Mikkelsen, Tom, deCarvalho, Ana C.

“…Abstract Platelet-derived growth factor receptor alpha (PDGFRA) is a ligand-activated receptor tyrosine kinase (RTK) involved in neurodevelopment. In pediatric…”
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Abstract 2519: Identification of novel MET fusion transcript amplification in glioblastoma by Nuga, Oluwademilade, deCarvalho, Ana, Meng, Yuling, Hasselbach, Laura, Nelson, Kevin, Irtenkauf, Susan, Transou, Andrea

“…Abstract Glioblastoma (GBM) is the most common and aggressive primary CNS malignant tumor with a 15.2% 2 year survival rate for tumors diagnosed between 2008…”
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TMOD-06. HIGH INCIDENCE OF TUMORS AFTER TREATMENT WITH A DNA-ALKYLATING AGENT IN MOUSE STRAINS COMMONLY USED IN PRE-CLINICAL STUDIES by Irtenkauf, Susan, Hasselbach, Laura, Transou, Andrea, Poisson, Laila, Noushmehr, Houtan, Rybkin, Igor, deCarvalho, Ana

“…Abstract Glioblastoma (GBM) is commonly treated with the DNA-alkylating agent temozolomide (TMZ). Silencing O6-methylguanine-DNA methyltransferase (MGMT) by…”
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Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma by Berezovsky, Artem D., Transou, Andrea D., Irtenkauf, Susan M., Hasselbach, Laura A., Koeman, Julie, Kim, Hoon, Verhaak, Roel G., Mikkelsen, Tom, Poisson, Laila M., deCarvalho, Ana C.

“…Abstract Background & Objective: Receptor tyrosine kinase (RTK) signaling is altered in over 80% of glioblastoma (GBM) cases, frequently through gene…”
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TMOD-36. DEVELOPMENT OF A PATIENT-DERIVED ORTHOTOPIC XENOGRAFT GLIOBLASTOMA MODEL PHENOTYPICALLY REPRESENTATIVE OF THE CLINICAL FEATURES by Nagaraja, Tavarekere, deCarvalho, Ana, Griffith, Brent, Brown, Stephen, Divine, George, Irtenkauf, Susan, Knight, Robert, Lee, Ian, Panda, Swayamprava, Cabral, Glauber, Ewing, James

“…Abstract In murine models, patient derived orthotopic xenografts (PDOXs) generated from neurosphere cultures of human glioblastomas (GBMs) are unmatched in…”
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Comparison of toluene-induced locomotor activity in four mouse strains by Bowen, Scott E., Kimar, Sarah, Irtenkauf, Susan

“…The mechanisms by which abused inhalants exert their neurobehavioral effects are only partially understood. In research with other drugs of abuse, specific…”
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Abstract 3860: Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patient-derived xenograft mouse models of glioblastoma by Nagaraja, Tavarekere N., Elmghirbi, Rasha, Irtenkauf, Susan, Hasselbach, Laura, Tawil, Baruch, Brown, Stephen L., Panda, Swayamprava, Cabral, Glauber, Mikkelsen, Tom, Ewing, James R., deCarvalho, Ana

“…Abstract Introduction: Patient-derived xenograft (PDX) models for glioblastoma (GBM) from resected tumor tissues replicate several features of the original…”
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Abstract 1755: TORK/DNA-PK inhibitor CC-115 is effective as a single agent in a subset of glioblastoma patient-derived cancer stem cells and xenografts and potentiates temozolomide therapy by Bergman, Kimberly, Irtenkauf, Susan M., Hasselbach, Laura A., Mueller, Claudius, Petricoin, Emanuel, Raymon, Heather, Mikkelsen, Tom, Decarvalho, Ana C.

“…Abstract Glioblastoma (GBM) cells are highly invasive and respond poorly to radiation and chemotherapy. The mammalian target of rapamycin (mTOR), a…”
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Abstract 628: A method to examine spatial relationships between tumor cells and vasculature using a mouse orthotopic PDX glioblastoma model by Nagaraja, Tavarekere N., Keenan, Kelly, Irtenkauf, Susan, Hasselbach, Laura, Panda, Swayamprava, Cabral, Glauber, Ewing, James R., Mikkelsen, Tom, deCarvalho, Ana

“…Abstract Introduction: Glioblastoma progression requires angiogenesis and/or vascular co-option. A major pathway for its infiltration is the perivascular…”
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Abstract 466: MR prediction of tumor burden in Patient-Derived Mouse Xenografts model of glioblastoma using an adaptive model by Bagher-Ebadian, Hassan, deCarvalho, Ana, Dehkordi, Azimeh NV, Nagaraja, Tavarekere, Irtenkauf, Susan, Panda, Swayamparva, Ali, Meser M., Ali, Arbab S., Soltanian-Zadeh, Hamid, Knight, Robert, Ewing, James R.

“…Abstract Introduction: In human glioblastoma multiforme (GBM), infiltrating cells are found in remote locations, even in the hemisphere contralateral to the…”
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Treatment of TBI with collagen scaffolds and human marrow stromal cells increases the expression of tissue plasminogen activator by Mahmood, Asim, Qu, Changsheng, Ning, Riuzuo, Wu, Hongtao, Goussev, Anton, Xiong, Ye, Irtenkauf, Susan, Li, Yi, Chopp, Michael

“…This study examines the effects of combination therapy of collagen scaffolds and human marrow stromal cells (hMSCs) on the expression of tissue plasminogen…”
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Abstract 427: Sox2 modulation of cancer stem cell behavior in GBM by Berezovsky, Artem D., Hong, Xin, Lemke, Nancy, Nelson, Kevin, Irtenkauf, Susan, Hasselbach, Laura, Mikkelsen, Tom, deCarvalho, Ana C.

“…Abstract Background and Objective: Glioblastoma (GBM) is the most aggressive primary brain tumor. GBM cells are phenotypically plastic and can present cancer…”
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