Search Results - "Irollo, Elena"
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Mechanisms of neuronal dysfunction in HIV-associated neurocognitive disorders
Published in Cellular and molecular life sciences : CMLS (01-05-2021)“…HIV-associated neurocognitive disorder (HAND) is characterized by cognitive and behavioral deficits in people living with HIV. HAND is still common in patients…”
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CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
Published in eLife (23-01-2020)“…Synaptodendritic pruning is a common cause of cognitive decline in neurological disorders, including HIV-associated neurocognitive disorders (HAND). HAND…”
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Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research
Published in Marine drugs (08-11-2013)“…An in-depth study of the secondary metabolites contained in the Caribbean sponge Smenospongia aurea led to the isolation of smenamide A (1) and B (2), hybrid…”
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Isolation and assessment of the in vitro anti-tumor activity of smenothiazole A and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea
Published in Marine drugs (16-01-2015)“…The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and…”
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Adult Human Brain Tissue Cultures to Study NeuroHIV
Published in Cells (Basel, Switzerland) (29-06-2024)“…HIV-associated neurocognitive disorders (HAND) persist under antiretroviral therapy as a complex pathology that has been difficult to study in cellular and…”
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CD133: to be or not to be, is this the real question?
Published in American journal of translational research (25-09-2013)“…CD133 (promini-1) is a member of the transmembrane glycoprotein family, was initially described as a specific marker to select human hematopoietic progenitor…”
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The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
Published in Molecular neurobiology (01-04-2023)“…Alteration of neuronal protein processing is often associated with neurological disorders and is highly dependent on cellular protein trafficking. A prime…”
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Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…Stress granules are nonmembranous organelles that function as a stress-adaptation mechanism. We have recently shown that stress granules are mobilized by…”
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The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain
Published in Journal of neuroimmune pharmacology (01-09-2023)“…NeuroHIV and other neurologic disorders present with altered iron metabolism in central nervous system neurons. Many people with HIV also use opioids, which…”
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Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…Opioid use has substantially increased over recent years and remains a major driver of new HIV infections worldwide. Clinical studies indicate that opioids may…”
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Sphingosine‐1‐phosphate/TGF‐β axis drives epithelial mesenchymal transition in asthma‐like disease
Published in British journal of pharmacology (01-04-2022)“…Background and Purpose Airway remodelling is a critical feature of chronic lung diseases. Epithelial‐mesenchymal transition (EMT) represents an important…”
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Collagen-X: a Novel Specific Stromal Biomarker for the Detection of Malignant Colorectal Carcinomas
Published 01-01-2018“…Colorectal Carcinoma (CRC) is the second most common malignant tumor in the Western world. It has been well documented that the tumor microenvironment plays an…”
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Dissertation -
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Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons
Published in eNeuro (01-07-2019)“…HIV-associated neurocognitive disorders (HAND) remain prevalent and are aggravated by µ-opioid use. We have previously shown that morphine and other µ-opioids…”
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Journal Article