Search Results - "Irma, B"

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation by Lee, Bettina L, Stowe, Irma B, Gupta, Aaron, Kornfeld, Opher S, Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P, Kayagaki, Nobuhiko

“…Intracellular LPS sensing by caspase-4/5/11 triggers proteolytic activation of pore-forming gasdermin D (GSDMD), leading to pyroptotic cell death in…”
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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 by Kayagaki, Nobuhiko, Wong, Michael T., Stowe, Irma B., Ramani, Sree Ranjani, Gonzalez, Lino C., Akashi-Takamura, Sachiko, Miyake, Kensuke, Zhang, Juan, Lee, Wyne P., Muszyński, Artur, Forsberg, Lennart S., Carlson, Russell W., Dixit, Vishva M.

“…Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri are sensed in an ill-defined manner by…”
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NINJ1 mediates plasma membrane rupture during lytic cell death by Kayagaki, Nobuhiko, Kornfeld, Opher S., Lee, Bettina L., Stowe, Irma B., O’Rourke, Karen, Li, Qingling, Sandoval, Wendy, Yan, Donghong, Kang, Jing, Xu, Min, Zhang, Juan, Lee, Wyne P., McKenzie, Brent S., Ulas, Gözde, Payandeh, Jian, Roose-Girma, Merone, Modrusan, Zora, Reja, Rohit, Sagolla, Meredith, Webster, Joshua D., Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Miosge, Lisa A., Goodnow, Christopher C., Bertram, Edward M., Dixit, Vishva M.

“…Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular…”
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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages by Lee, Bettina L., Mirrashidi, Kathleen M., Stowe, Irma B., Kummerfeld, Sarah K., Watanabe, Colin, Haley, Benjamin, Cuellar, Trinna L., Reichelt, Michael, Kayagaki, Nobuhiko

“…The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation…”
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling by Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O’Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie R., Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne P., Snipas, Scott J., Salvesen, Guy S., Morris, Lucy X., Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward M., Goodnow, Christopher C., Dixit, Vishva M.

“…Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli , Salmonella typhimurium , Shigella flexneri , and Burkholderia…”
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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition by Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

“…The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological…”
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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury by Kayagaki, Nobuhiko, Stowe, Irma B., Alegre, Kamela, Deshpande, Ishan, Wu, Shuang, Lin, Zhonghua, Kornfeld, Opher S., Lee, Bettina L., Zhang, Juan, Liu, John, Suto, Eric, Lee, Wyne P., Schneider, Kellen, Lin, WeiYu, Seshasayee, Dhaya, Bhangale, Tushar, Chalouni, Cecile, Johnson, Matthew C., Joshi, Prajakta, Mossemann, Jan, Zhao, Sarah, Ali, Danish, Goldenberg, Neil M., Sayed, Blayne A., Steinberg, Benjamin E., Newton, Kim, Webster, Joshua D., Kelly, Ryan L., Dixit, Vishva M.

“…Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1 1 . PMR releases pro-inflammatory…”
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Mechanism of cadmium-induced nephrotoxicity by Bautista, Claudia J., Arango, Nidia, Plata, Consuelo, Mitre-Aguilar, Irma B., Trujillo, Joyce, Ramírez, Victoria

“…Heavy metals are found naturally in our environment and have many uses and applications in daily life. However, high concentrations of metals may be a result…”
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A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1 by Stowe, Irma B, Mercado, Ellen L, Stowe, Timothy R, Bell, Erika L, Oses-Prieto, Juan A, Hernández, Hilda, Burlingame, Alma L, McCormick, Frank

“…The Ras/mitogen-activated protein kinase (MAPK) pathway plays a critical role in transducing mitogenic signals from receptor tyrosine kinases. Loss-of-function…”
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Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells by Montiel-Dávalos, Angélica, Silva Sánchez, Guadalupe Jazmin, Huerta-García, Elizabeth, Rueda-Romero, Cristhiam, Soca Chafre, Giovanny, Mitre-Aguilar, Irma B, Alfaro-Moreno, Ernesto, Pedraza-Chaverri, José, López-Marure, Rebeca

“…Curcumin has protective effects against toxic agents and shows preventive properties for various diseases. Particulate material with an aerodynamic diameter of…”
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Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture by Pourmal, Sergei, Truong, Melissa E, Johnson, Matthew C, Yang, Ying, Zhou, Lijuan, Alegre, Kamela, Stowe, Irma B, Gupta, Shalini, Chen, Phoebe A, Zhang, Yingnan, Rohou, Alexis, Newton, Kim, Kayagaki, Nobuhiko, Dixit, Vishva M, Deshpande, Ishan

“…Lytic cell death culminates in plasma membrane rupture (PMR), which releases large intracellular molecules to augment the inflammatory response. PMR is…”
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The Role of Glucocorticoids in Breast Cancer Therapy by Mitre-Aguilar, Irma B, Moreno-Mitre, Daniel, Melendez-Zajgla, Jorge, Maldonado, Vilma, Jacobo-Herrera, Nadia J, Ramirez-Gonzalez, Victoria, Mendoza-Almanza, Gretel

“…Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the adrenal gland and regulated by the…”
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Racial/Ethnic Differences in Hypertension Prevalence, Treatment, and Control for Outpatients in Northern California 2010–2012 by Zhao, Beinan, Jose, Powell O., Pu, Jia, Chung, Sukyung, Ancheta, Irma B., Fortmann, Stephen P., Palaniappan, Latha P.

“…BACKGROUND Hypertension (HTN) is a known major cardiovascular disease risk factor, but prevalence, treatment, and control of HTN among rapidly growing minority…”
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Genomic and non-genomic effects of glucocorticoids: implications for breast cancer by Mitre-Aguilar, Irma B, Cabrera-Quintero, Alberto J, Zentella-Dehesa, Alejandro

“…Glucocorticoids (GC) are essential steroid hormones for human life. They regulate a series of important processes by binding with three glucocorticoid…”
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Gene Expression Behavior of a Set of Genes in Platelet and Tissue Samples from Patients with Breast Cancer by Burciaga-Hernandez, Luis A, Cueto-Villalobos, Cecilia F, Ortega-Piñon, Nancy, Gonzalez-Curiel, Irma E, Godina-Gonzalez, Susana, Mendez-Frausto, Gwendolyne, Aguilar-Esquivel, Anna P, Maldonado-Lagunas, Vilma, Guerrero-de la Torre, Luis E, Melendez-Zajgla, Jorge, Sanchez-Garcia, Erika K, Mitre-Aguilar, Irma B, Mendoza-Almanza, Gretel

“…The tumor microenvironment (TME) is constituted by a great diversity of highly dynamic cell populations, each of which contributes ligands, receptors, soluble…”
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Genetic effects of ionizing radiation – some questions with no answers by Mosse, Irma B.

“…There are a lot of questions about genetic effects of ionizing radiation, the main one is does ionizing radiation induce mutations in humans? There is no…”
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Tumor Microenvironment Role in Pancreatic Cancer Stem Cells by Galindo-Vega, Aaron, Maldonado-Lagunas, Vilma, Mitre-Aguilar, Irma B, Melendez-Zajgla, Jorge

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a majority of patients presenting with unresectable or metastatic disease, resulting…”
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User stories as lightweight requirements for agile clinical decision support development by Kannan, Vaishnavi, Basit, Mujeeb A, Bajaj, Puneet, Carrington, Angela R, Donahue, Irma B, Flahaven, Emily L, Medford, Richard, Melaku, Tsedey, Moran, Brett A, Saldana, Luis E, Willett, Duwayne L, Youngblood, Josh E, Toomay, Seth M

“…Abstract Objective We sought to demonstrate applicability of user stories, progressively elaborated by testable acceptance criteria, as lightweight…”
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Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells by Mitre-Aguilar, Irma B, Barrios-Garcia, Tonatiuh, Ruiz-Lopez, Victor M, Cabrera-Quintero, Alberto J, Mejia-Dominguez, Nancy R, Ventura-Gallegos, Jose L, Moreno-Mitre, Daniel, Aranda-Gutierrez, Alejandro, Mejia-Rangel, Janini, Escalona-Guzman, Alma R, Chavarri-Guerra, Yanin, Leon-Del-Rio, Alfonso, Zentella-Dehesa, Alejandro

“…Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor…”
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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition by Walle, Lieselotte Vande, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubr, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

“…[This corrects the article DOI: 10.1371/journal.pbio.3000354.]…”
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