Search Results - "Irlbacher, Horst"

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target by Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

“…MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool…”
Get full text

Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy by Kober, Christina, Roewe, Julian, Schmees, Norbert, Roese, Lars, Roehn, Ulrike, Bader, Benjamin, Stoeckigt, Detlef, Prinz, Florian, Gorjánácz, Mátyás, Roider, Helge Gottfried, Olesch, Catherine, Leder, Gabriele, Irlbacher, Horst, Lesche, Ralf, Lefranc, Julien, Oezcan-Wahlbrink, Mine, Batra, Ankita Sati, Elmadany, Nirmeen, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Cichon, Frederik, Baumann, Daniel, Sadik, Ahmed, Opitz, Christiane A, Weinmann, Hilmar, Hartung, Ingo V, Kreft, Bertolt, Offringa, Rienk, Platten, Michael, Gutcher, Ilona

“…BackgroundThe metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and…”
Get full text

Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel by Ziera, Tim, Irlbacher, Horst, Fromm, Anja, Latouche, Celine, Krug, Susanne M, Fromm, Michael, Jaisser, Frederic, Borden, Steffen A

“…Aldosterone is the principal hormonal regulator of sodium homeostasis in vertebrates. It exerts its actions through the mineralocorticoid receptor (MR) that…”
Get full text

Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression by Irlbacher, Horst, Franke, Jacqueline, Manke, Thomas, Vingron, Martin, Ehrenhofer-Murray, Ann E

“…Heterochromatinization at the silent mating-type loci HMR and HML in Saccharomyces cerevisiae is achieved by targeting the Sir complex to these regions via a…”
Get full text

Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase by Weber, Jan M, Irlbacher, Horst, Ehrenhofer-Murray, Ann E

“…Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications,…”
Get full text

Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor by Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret

“…The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKε are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase…”
Get full text

Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor by Langer, Gernot, Scott, John, Lind, Christoffer, Otto, Christiane, Bothe, Ulrich, Laux-Biehlmann, Alexis, Müller, Jörg, le Roy, Beau, Irlbacher, Horst, Nowak-Reppel, Katrin, Schlüter, Anne, Davenport, Adam J, Slack, Mark, Bäurle, Stefan

“…The human pituitary adenylate cyclase-activating polypeptide receptor (hPAC -R), a class B G-protein-coupled receptor (GPCR) identified almost 30 years ago,…”
Get full text

Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A by Wortmann, Lars, Bräuer, Nico, Holton, Simon J, Irlbacher, Horst, Weiske, Jörg, Lechner, Christian, Meier, Robin, Karén, Jakob, Siöberg, Catrine Berthold, Pütter, Vera, Christ, Clara D, ter Laak, Antonius, Lienau, Philip, Lesche, Ralf, Nicke, Barbara, Cheung, Shing-Hu, Bauser, Marcus, Haegebarth, Andrea, von Nussbaum, Franz, Mumberg, Dominik, Lemos, Clara

“…PIP4K2A is an insufficiently studied type II lipid kinase that catalyzes the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol…”
Get full text

Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis by Koppitz, Marcus, Bräuer, Nico, Ter Laak, Antonius, Irlbacher, Horst, Rotgeri, Andrea, Coelho, Anne-Marie, Walter, Daryl, Steinmeyer, Andreas, Zollner, Thomas M., Peters, Michaele, Nagel, Jens

“…[Display omitted] Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES…”
Get full text

Abstract 4454: Identification of BAY-218, a potent and selective small-molecule AhR inhibitor, as a new modality to counteract tumor immunosuppression by Schmees, Norbert, Gutcher, Ilona, Roehn, Ulrike, Irlbacher, Horst, Stoeckigt, Detlef, Bader, Benjamin, Kober, Christina, Roese, Lars, Carretero, Rafael, Oezen, Iris, Zorn, Ludiwg, Platten, Michael, Hartung, Ingo Volker, Kreft, Bertolt, Weinmann, Hilmar

“…Abstract Re-constitution of anti-tumor T-cell responses by clinically-approved immune checkpoint inhibitors (ICIs) targeting CTLA4 or PD-1/PD-L1 represents a…”
Get full text

Abstract 1288: Blocking tumor-associated immune suppression with BAY-218, a novel, selective aryl hydrocarbon receptor (AhR) inhibitor by Gutcher, Ilona, Kober, Christina, Roese, Lars, Roewe, Julian, Schmees, Norbert, Prinz, Florian, Gorjanacz, Matyas, Roehn, Ulrike, Bader, Benjamin, Irlbacher, Horst, Stoeckigt, Detlef, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Weinmann, Hilmar, Hartung, Ingo V., Kreft, Bertolt, Platten, Michael

“…Abstract Tumor cells co-opt multiple pathways in order to evade attack by infiltrating immune cells. One such mechanism is the upregulation of…”
Get full text

Abstract 4460: Targeting the redox-protective protein MTH1 for cancer therapy: A novel way to exploit the unique redox status of cancer cells by Glasauer, Andrea, Irlbacher, Horst, Richter, Anja, Toschi, Luisella, Steckel, Michael, Haegebarth, Andrea

“…Abstract Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS) production and an altered redox environment compared to…”
Get full text

Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 by Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

“…Abstract Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular…”
Get full text

Differential expression of antenna and core genes in Prochlorococcus PCC 9511 (Oxyphotobacteria) grown under a modulated light-dark cycle by Garczarek, Laurence, Partensky, Frédéric, Irlbacher, Horst, Holtzendorff, Julia, Babin, Marcel, Mary, Isabelle, Thomas, Jean Claude, Hess, Wolfgang R.

“…The continuous changes in incident solar light occurring during the day oblige oxyphototrophs, such as the marine prokaryote Prochlorococcus, to modulate the…”
Get full text