Search Results - "Irion, Uwe"

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system by Irion, Uwe, Krauss, Jana, Nüsslein-Volhard, Christiane

“…The introduction of engineered site-specific DNA endonucleases has brought precise genome editing in many model organisms and human cells into the realm of…”
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The identification of genes involved in the evolution of color patterns in fish by Irion, Uwe, Nüsslein-Volhard, Christiane

“…The genetic basis of morphological variation, both within and between species, provides a major topic in evolutionary biology. Teleost fish produce most…”
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Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifs by Irion, Uwe

“…Muscleblind-like proteins, Muscleblind (Mbl) in Drosophila and MBNL1-3 in vertebrates, are regulators of alternative splicing. Human MBNL1 is a key factor in…”
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Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish by Podobnik, Marco, Frohnhöfer, Hans Georg, Dooley, Christopher M., Eskova, Anastasia, Nüsslein-Volhard, Christiane, Irion, Uwe

“…The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns…”
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Author Correction: Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish by Podobnik, Marco, Frohnhöfer, Hans Georg, Dooley, Christopher M., Eskova, Anastasia, Nüsslein-Volhard, Christiane, Irion, Uwe

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bicoid RNA localization requires specific binding of an endosomal sorting complex by Irion, Uwe, St Johnston, Daniel

“…bicoid messenger RNA localizes to the anterior of the Drosophila egg, where it is translated to form a morphogen gradient of Bicoid protein that patterns the…”
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ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells by Fadeev, Andrey, Mendoza-Garcia, Patricia, Irion, Uwe, Guan, Jikui, Pfeifer, Kathrin, Wiessner, Stephanie, Serluca, Fabrizio, Singh, Ajeet Pratap, Nüsslein-Volhard, Christiane, Palmer, Ruth H.

“…Mutations in anaplastic lymphoma kinase (ALK) are implicated in somatic and familial neuroblastoma, a pediatric tumor of neural crest-derived tissues…”
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Tight Junction Protein 1a regulates pigment cell organisation during zebrafish colour patterning by Fadeev, Andrey, Krauss, Jana, Frohnhöfer, Hans Georg, Irion, Uwe, Nüsslein-Volhard, Christiane

“…Zebrafish display a prominent pattern of alternating dark and light stripes generated by the precise positioning of pigment cells in the skin. This arrangement…”
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Efficient genome editing using modified Cas9 proteins in zebrafish by Dorner, Laura, Stratmann, Benedikt, Bader, Laura, Podobnik, Marco, Irion, Uwe

“…The zebrafish (Danio rerio) is an important model organism for basic as well as applied bio-medical research. One main advantage is its genetic tractability,…”
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Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish by Irion, Uwe, Frohnhöfer, Hans Georg, Krauss, Jana, Çolak Champollion, Tuǧba, Maischein, Hans-Martin, Geiger-Rudolph, Silke, Weiler, Christian, Nüsslein-Volhard, Christiane

“…Interactions between all three pigment cell types are required to form the stripe pattern of adult zebrafish (Danio rerio), but their molecular nature is…”
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Loss‐of‐function mutations in the melanocortin 1 receptor cause disruption of dorso‐ventral countershading in teleost fish by Cal, Laura, Suarez‐Bregua, Paula, Braasch, Ingo, Irion, Uwe, Kelsh, Robert, Cerdá‐Reverter, Jose Miguel, Rotllant, Josep

“…The melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat…”
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bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring by Trovisco, Vítor, Belaya, Katsiaryna, Nashchekin, Dmitry, Irion, Uwe, Sirinakis, George, Butler, Richard, Lee, Jack J, Gavis, Elizabeth R, St Johnston, Daniel

“…mRNA localises to the oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at…”
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Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment by Eskova, Anastasia, Chauvigné, Francois, Maischein, Hans-Martin, Ammelburg, Moritz, Cerdà, Joan, Nüsslein-Volhard, Christiane, Irion, Uwe

“…The development of the pigmentation pattern in zebrafish is a tightly regulated process that depends on both the self-organizing properties of pigment cells…”
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Response to Comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish” by Singh, Ajeet Pratap, Frohnhöfer, Hans-Georg, Irion, Uwe, Nüsslein-Volhard, Christiane

“…Watanabe and Kondo question our conclusion that the current Turing-type model of color patterning in zebrafish requires modification. In addition to…”
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A dominant mutation in tyrp1A leads to melanophore death in zebrafish by Krauss, Jana, Geiger-Rudolph, Silke, Koch, Iris, Nüsslein-Volhard, Christiane, Irion, Uwe

“…Summary Melanin biosynthesis in vertebrates depends on the function of three enzymes of the tyrosinase family, tyrosinase (Tyr), tyrosinase‐related protein 1…”
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Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish by Mahalwar, Prateek, Singh, Ajeet Pratap, Fadeev, Andrey, Nüsslein-Volhard, Christiane, Irion, Uwe

“…The conspicuous striped coloration of zebrafish is produced by cell-cell interactions among three different types of chromatophores: black melanophores,…”
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Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors by Chang, Chin-Wen, Nashchekin, Dmitry, Wheatley, Lucy, Irion, Uwe, Dahlgaard, Katja, Montague, Tessa G, Hall, Jacqueline, St Johnston, Daniel

“…The Drosophila melanogaster anterior-posterior axis is established during oogenesis by the localization of bicoid and oskar mRNAs to the anterior and posterior…”
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Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish by Frohnhöfer, Hans Georg, Geiger-Rudolph, Silke, Pattky, Martin, Meixner, Martin, Huhn, Carolin, Maischein, Hans-Martin, Geisler, Robert, Gehring, Ines, Maderspacher, Florian, Nüsslein-Volhard, Christiane, Irion, Uwe

“…Polyamines are small poly-cations essential for all cellular life. The main polyamines present in metazoans are putrescine, spermidine and spermine. Their…”
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Endothelin signalling in iridophore development and stripe pattern formation of zebrafish by Krauss, Jana, Frohnhöfer, Hans Georg, Walderich, Brigitte, Maischein, Hans-Martin, Weiler, Christian, Irion, Uwe, Nüsslein-Volhard, Christiane

“…Colour patterns of adult fish are composed of several different types of pigment cells distributing in the skin during juvenile development. The zebrafish,…”
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Differentiated muscles are mandatory for gas-filling of the Drosophila airway system by Wang, Yiwen, Cruz, Tina, Irion, Uwe, Moussian, Bernard

“…At the end of development, organs acquire functionality, thereby ensuring autonomy of an organism when it separates from its mother or a protective egg. In…”
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