Search Results - "Irby, Rosalyn B"

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway by Krishnegowda, Gowdahalli, Prakasha Gowda, A.S., Tagaram, Hephzibah Rani S., Carroll, Kevin F. Staveley-O’, Irby, Rosalyn B., Sharma, Arun K., Amin, Shantu

“…A novel series of 5,7-dibromoisatin analogs were synthesized and evaluated for their cytotoxicities against four human cancer cell lines including colon HT29,…”
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The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer by Allen, Joshua E, Gallant, Jean-Nicolas, Dicker, David T, Amin, Shantu, Irby, Rosalyn B, Sharma, Arun K, El-Deiry, Wafik S

“…Phenylbutyl isoselenocyanate (ISC-4) is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to…”
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Epidermal growth factor receptor revisited: Prognostic marker or target for therapy? by Irby, Rosalyn B.

“…Commentary to: EGFR expression variance in paired colorectal cancer primary and metastatic tumors Nirit Yarom, Celia Marginean, Terence Moyana, Ivan…”
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Activating SRC mutation in a subset of advanced human colon cancers by Yeatman, Timothy J, Irby, Rosalyn B, Mao, Weiguang, Coppola, Domenico, Kang, Jimmy, Loubeau, Jean Marc, Trudeau, Walter, Karl, Richard, Fujita, Donald J, Jove, Richard

“…The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in…”
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Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network by Wang, Bi-Dar, Kline, Christina Leah B., Pastor, Danielle M., Olson, Thomas L., Frank, Bryan, Luu, Truong, Sharma, Arun K., Robertson, Gavin, Weirauch, Matthew T., Patierno, Steven R., Stuart, Joshua M., Irby, Rosalyn B., Lee, Norman H.

“…Abstract Background Diminished expression or activity of prostate apoptosis response protein 4 (Par-4) has been demonstrated in a number of cancers, although…”
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TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells by Nguyen, Jeffrey Q., Irby, Rosalyn B.

“…The prostate apoptosis response protein 4 (Par-4) is a tumor-suppressor that has been shown to induce cancer-cell selective apoptosis in a variety of cancers…”
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Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU by Kline, Christina Leah, Shanmugavelandy, Sriram S., Kester, Mark, Irby, Rosalyn B.

“…The prostate apoptosis response protein 4 (Par-4), a tumor suppressor, has been shown to induce apoptosis in cancer cells. While reduced Par-4 expression has…”
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Correction: The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer by Allen, Joshua E., Gallant, Jean-Nicolas, Dicker, David T., Amin, Shantu, Irby, Rosalyn B., Sharma, Arun K., El-Deiry, Wafik S.

“…Summary of combinatorial effects of ISC-4 with approved antitumor agents. (2013) Correction: The Akt Inhibitor ISC-4 Synergizes with Cetuximab in…”
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Identification of Src transformation fingerprint in human colon cancer by Malek, Renae L, Irby, Rosalyn B, Guo, Qingbin M, Lee, Kerry, Wong, Sylvia, He, Mei, Tsai, Jennifer, Frank, Bryan, Liu, Edison T, Quackenbush, John, Jove, Richard, Yeatman, Timothy J, Lee, Norman H

“…We used a classical rodent model of transformation to understand the transcriptional processes, and hence the molecular and cellular events a given cell…”
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Iterative microarray and RNA interference-based interrogation of the Src-induced invasive phenotype by IRBY, Rosalyn B, MALEK, Renae L, BLOOM, Greg, TSAI, Jennifer, LETWIN, Noah, FRANK, Bryan C, VERRATTI, Kathleen, YEATMAN, Timothy J, LEE, Norman H

“…Src kinase has long been recognized as a factor in the progression of colorectal cancer and seems to play a specific role in the development of the metastatic…”
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Role of Src expression and activation in human cancer by Irby, R B, Yeatman, T J

“…Since the original identification of a transmissible agent responsible for the development of tumors in chickens, now known to be a retrovirus encoding the…”
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The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model by SHARMA, Arun K, KLINE, Christina L, BERG, Arthur, AMIN, Shantu, IRBY, Rosalyn B

“…Prostate apoptosis response protein-4 (Par-4) sensitizes cells to chemotherapy; however, Akt1 inactivates Par-4. Previously we showed that Par-4-overexpressing…”
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Par-4 as a potential target for cancer therapy by Irby, Rosalyn B, Kline, Christina L B

“…Despite extensive research, cancer continues to be a leading cause of death worldwide and is expected to continue to rise as a result of an aging population…”
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Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells by IRBY, Rosalyn B, YEATMAN, Timothy J

“…Src has been implicated in the development and progression of human colon cancer. Because the capacity for tumor cells to dissociate from the primary tumor is…”
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The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU by Kline, Christina Leah B., Irby, Rosalyn B.

“…The overexpression of the pro-apoptotic protein Prostate Apoptosis Response Protein-4 in colon cancer has been shown to increase response to the…”
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Tumor Necrosis Factor α Induces p53 Up-regulated Modulator of Apoptosis Expression in Colorectal Cancer Cell Lines by Pastor, Danielle M, Irby, Rosalyn B, Poritz, Lisa S

“…PURPOSE:Inflammatory bowel disease (IBD)–associated colorectal carcinogenesis involves dysregulation of multiple cellular pathways, including p53 signaling and…”
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Src kinase induces tumor formation in the c‐SRC C57BL/6 mouse by Kline, Christina Leah B., Jackson, Rosalind, Engelman, Robert, Pledger, Warren Jack, Yeatman, Timothy J., Irby, Rosalyn B.

“…Src kinase has been linked as a causative agent in the progression of a number of cancers including colon, breast, lung and melanoma. Src protein and activity…”
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Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression by Cook, Amy C., Tuck, Alan B., McCarthy, Susan, Turner, Joel G., Irby, Rosalyn B., Bloom, Gregory C., Yeatman, Timothy J., Chambers, Ann F.

“…Tumor progression is a multistep process, which enables cells to evolve from benign to malignant tumors. This progression has been suggested to depend on six…”
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Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study by Nyland, Susan Bell, Krissinger, Daniel J, Clemente, Michael J, Irby, Rosalyn B, Baab, Kendall Thomas, Jarbadan, Nancy Ruth, Sokol, Lubomir, Schaefer, Eric, Liao, Jason, Cuthbertson, David, Epling-Burnette, Pearlie, Paquette, Ronald, List, Alan F, Maciejewski, Jaroslaw P, Loughran, Thomas P

“…Abstract Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently…”
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Src activity alters α3 integrin expression in colon tumor cells by Kline, Christina Leah B, Olson, Thomas L, Irby, Rosalyn B

“…Src kinase has been linked to increased motility in the progression and metastasis of human colon cancer, although the mechanisms are not fully understood…”
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