Search Results - "Irazoqui, Fernando J."

How glycobiology can help us treat and beat the COVID-19 pandemic by Lardone, Ricardo D., Garay, Yohana C., Parodi, Pedro, de la Fuente, Sofia, Angeloni, Genaro, Bravo, Eduardo O., Schmider, Anneke K., Irazoqui, Fernando J.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible…”
Get full text

Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus by Cejas, Romina B., Lorenz, Virginia, Garay, Yohana C., Irazoqui, Fernando J.

“…Biological functions of nuclear proteins are regulated by post-translational modifications (PTMs) that modulate gene expression and cellular physiology…”
Get full text

Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis by Lorenz, Virginia, Ditamo, Yanina, Cejas, Romina B., Carrizo, Maria E., Bennett, Eric P., Clausen, Henrik, Nores, Gustavo A., Irazoqui, Fernando J.

“…Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the…”
Get full text

The Antineoplastic Lectin of the Common Edible Mushroom (Agaricus bisporus) Has Two Binding Sites, Each Specific for a Different Configuration at a Single Epimeric Hydroxyl by Carrizo, Maria E., Capaldi, Stefano, Perduca, Massimiliano, Irazoqui, Fernando J., Nores, Gustavo A., Monaco, Hugo L.

“…The lectin from the common mushroom Agaricus bisporus, the most popular edible species in Western countries, has potent antiproliferative effects on human…”
Get full text

Neurological disorders-associated anti-glycosphingolipid IgG-antibodies display differentially restricted IgG subclass distribution by Lardone, Ricardo D., Irazoqui, Fernando J., Nores, Gustavo A.

“…Antibodies against several self-glycans on glycosphingolipids are frequently detected in different neurological disorders. Their pathogenic role is profusely…”
Get full text

Correction: Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus by Cejas, Romina B., Lorenz, Virginia, Garay, Yohana C., Irazoqui, Fernando J.

Get full text

ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1 by Deza-Ponzio, Romina, Albrecht, Paula A., Fernandez-Hubeid, Lucia E., Eichwald, Tuany, Cejas, Romina B., Garay, Yohana C., Rivera-Meza, Mario, Latini, Alexandra, Irazoqui, Fernando J., Virgolini, Miriam B.

“…Lead (Pb), a common environmental contaminant, and ethanol (EtOH), a widely available drug of abuse, are well-known neurotoxicants. In vivo, experimental…”
Get full text

Purified human anti-Tn and anti-T antibodies specifically recognize carcinoma tissues by Zlocowski, Natacha, Grupe, Veronica, Garay, Yohana C., Nores, Gustavo A., Lardone, Ricardo D., Irazoqui, Fernando J.

“…Described in several epithelial cancer cells, Tn- (GalNAcα1-O-Ser/Thr) and T- (Galβ3GalNAcα1-O-Ser/Thr) antigens are examples of tumor-associated antigens…”
Get full text

Individual Restriction Of Fine Specificity Variability In Anti-GM1 IgG Antibodies Associated With Guillain-Barré Syndrome by Lardone, Ricardo D., Yuki, Nobuhiro, Irazoqui, Fernando J., Nores, Gustavo A.

“…Elevated titers of serum antibodies against GM1 ganglioside are associated with a variety of autoimmune neuropathies. Much evidence indicates these…”
Get full text

Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering by Funes, Samanta C., Chiari, María Eugenia, Comín, Romina, Irazoqui, Fernando J., Nores, Gustavo A.

“…An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an…”
Get full text

Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain by Lorenz, Virginia, Cejas, Romina B, Bennett, Eric P, Nores, Gustavo A, Irazoqui, Fernando J

“…O-GalNAc glycans are important structures in cellular homeostasis. Their biosynthesis is initiated by members of the polypeptide GalNAc-transferase…”
Get more information

In vivo immunomodulatory effect of the lectin from edible mushroom Agaricus bisporus by Ditamo, Yanina, Rupil, Lucia L, Sendra, Victor G, Nores, Gustavo A, Roth, German A, Irazoqui, Fernando J

“…Lectins are glycan-binding proteins that are resistant to digestion in the gastrointestinal tract and enter intact to blood circulation. The aim of this study…”
Get more information

An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2 by Zlocowski, Natacha, Lorenz, Virginia, Bennett, Eric P, Clausen, Henrik, Nores, Gustavo A, Irazoqui, Fernando J

“…Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation of mucin-type O-glycosylation. All ppGalNAc-T family members…”
Get more information

Correlative Fine Specificity of Several Thomsen-Friedenreich Disaccharide-Binding Proteins with an Effect on Tumor Cell Proliferation by Irazoqui, Fernando J., Jansson, Bo, Lopez, Pablo H.H., Nores, Gustavo A.

“…Epithelial cancer cells show increased cell surface expression of mucin antigens with aberrant O-glycosylation, notably type I core (Galβ1-3GalNAcα), termed…”
Get full text

Anti-GM1 IgG antibodies in Guillain–Barré syndrome: fine specificity is associated with disease severity by Lardone, Ricardo D, Yuki, Nobuhiro, Odaka, Masaaki, Daniotti, Jose L, Irazoqui, Fernando J, Nores, Gustavo A

“…BackgroundClinical severity of Guillain–Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown.ObjectiveThe study was designed…”
Get full text

Anti-GM1 antibodies as a model of the immune response to self-glycans by Nores, Gustavo A., Lardone, Ricardo D., Comín, Romina, Alaniz, María E., Moyano, Ana L., Irazoqui, Fernando J.

“…Glycans are a class of molecules with high structural variability, frequently found in the plasma membrane facing the extracellular space. Because of these…”
Get full text

Anti-idiotypic antibody mimicking a T-antigen-specific lectin inhibits human epithelial tumor cell proliferation by Sendra, Victor G, Zlocowski, Natacha, Nores, Gustavo A, Irazoqui, Fernando J

“…Cancer‐associated mucins show frequent alterations of oligosaccharide chain profile. Terminal structures may be deleted, thereby exposing normally ‘cryptic’…”
Get full text

Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation by Zlocowski, Natacha, Sendra, Victor G., Lorenz, Virginia, Villarreal, Marcos A., Jorge, Alberto, Núñez, Yolanda, Bennett, Eric P., Clausen, Henrik, Nores, Gustavo A., Irazoqui, Fernando J.

“…► Glycosyltransferase activity of ppGalNAc-T2 was reduced by acetylation. ► Acetylation of ppGalNAc-T2 enhances the recognition to αGalNAc of MUC1αGalNAc. ►…”
Get full text

Novel antibodies reacting with two neighboring gangliosides are induced in rabbits immunized with bovine brain gangliosides by Moyano, Ana L, Comín, Romina, Vilcaes, Aldo A, Funes, Samanta C, Roth, Germán A, Irazoqui, Fernando J, Nores, Gustavo A

“…Immunization of rabbits with bovine brain gangliosides induced an experimental neuropathy, with clinical signs resembling Guillain-Barré syndrome. All the…”
Get full text

Glycan bioengineering in immunogen design for tumor T antigen immunotargeting by Sendra, Victor G., Zlocowski, Natacha, Ditamo, Yanina, Copioli, Silvina, Tarp, Mads P., Bennett, Eric P., Clausen, Henrik, Roth, German A., Nores, Gustavo A., Irazoqui, Fernando J.

“…Bioengineering of Galβ3GalNAcα, known as Thomsen–Friedenreich disaccharide (TFD), is studied to promote glycan immunogenicity and immunotargeting to tumor T…”
Get full text