Search Results - "Iraburu, María J."

AGAP2: Modulating TGFβ1-Signaling in the Regulation of Liver Fibrosis by Navarro-Corcuera, Amaia, Ansorena, Eduardo, Montiel-Duarte, Cristina, Iraburu, María J

“…AGAP2 (Arf GAP with GTP-binding protein-like domain, Ankyrin repeat and PH domain 2) isoform 2 is a protein that belongs to the Arf GAP (GTPase activating…”
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NADPH oxidase 5 promotes proliferation and fibrosis in human hepatic stellate cells by Andueza, Aitor, Garde, Naiara, García-Garzón, Antonia, Ansorena, Eduardo, López-Zabalza, María J., Iraburu, María J., Zalba, Guillermo, Martínez-Irujo, Juan J.

“…NADPH oxidase (Nox) variants Nox1, Nox2 and Nox4 are implicated in the progression of liver fibrosis. However, the role of Nox5 is not yet known, mainly due to…”
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Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells by Navarro-Corcuera, Amaia, López-Zabalza, María J., Martínez-Irujo, Juan J., Álvarez-Sola, Gloria, Ávila, Matías A., Iraburu, María J., Ansorena, Eduardo, Montiel-Duarte, Cristina

“…Liver damage induces hepatic stellate cells (HSC) activation, characterised by a fibrogenic, proliferative and migratory phenotype. Activated HSC are mainly…”
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Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway by de Galarreta, Marina Ruiz, Navarro, Amaia, Ansorena, Eduardo, Garzón, Antonia García, Mòdol, Teresa, López-Zabalza, María J., Martínez-Irujo, Juan J., Iraburu, María J.

“…Unfolded protein response (UPR) triggered as a consequence of ER stress has been shown to be involved in the development of different pathologies, including…”
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Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells by Ruiz de Galarreta, Marina, Arriazu, Elena, Pérez de Obanos, María P., Ansorena, Eduardo, Iraburu, María J.

“…Ocoxin is a nutritional supplement that has been shown to exert antioxidant and immunomodulatory responses in patients with chronic hepatitis C. The present…”
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Fibronectin Peptides as Potential Regulators of Hepatic Fibrosis Through Apoptosis of Hepatic Stellate Cells by Mòdol, Teresa, Brice, Natalia, Ruiz de Galarreta, Marina, García Garzón, Antonia, Iraburu, María J., Martínez-Irujo, Juan J., López-Zabalza, María J.

“…The turnover of extracellular matrix (ECM) components can generate signals that regulate several cellular functions such as proliferation, differentiation, and…”
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Oxidation pathways underlying the pro-oxidant effects of apigenin by Andueza, Aitor, García-Garzón, Antonia, Ruiz de Galarreta, Marina, Ansorena, Eduardo, Iraburu, María J., López-Zabalza, María J., Martínez-Irujo, Juan J.

“…Apigenin, a natural flavone, is emerging as a promising compound for the treatment of several diseases. One of the hallmarks of apigenin is the generation of…”
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GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice by Arriazu, Elena, Ruiz de Galarreta, Marina, López-Zabalza, María J, Leung, Tung Ming, Nieto, Natalia, Iraburu, María J

“…General control nonderepresible 2 (GCN2) is a highly conserved cytosolic kinase that modulates a complex response for coping with the stress owing to lack of…”
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Apoptosis of hepatic stellate cells mediated by specific protein nitration by Mòdol, Teresa, Natal, Cristina, Pérez de Obanos, María P., Domingo de Miguel, Eduardo, Iraburu, María J., López-Zabalza, María J.

“…Inflammatory conditions are characterized by continuous overproduction of nitric oxide (NO) that can contribute to cell survival but also to cell demise by…”
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Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells by Pérez de Obanos, María P., López-Zabalza, María J., Arriazu, Elena, Modol, Teresa, Prieto, Jesús, Herraiz, María T., Iraburu, María J.

“…The amino acid leucine causes an increase of collagen α1(I) synthesis in hepatic stellate cells through the activation of translational regulatory mechanisms…”
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Revising Endosomal Trafficking under Insulin Receptor Activation by Iraburu, Maria J., Garner, Tommy, Montiel-Duarte, Cristina

“…The endocytosis of ligand-bound receptors and their eventual recycling to the plasma membrane (PM) are processes that have an influence on signalling activity…”
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Specific protein nitration in nitric oxide-induced apoptosis of human monocytes by Natal, Cristina, Modol, Teresa, Osés-Prieto, Juan A, López-Moratalla, Natalia, Iraburu, María J, López-Zabalza, María J

“…The sustained overproduction of nitric oxide (NO) observed in inflammatory conditions can contribute to cell demise by affecting apoptosis. Nitration of…”
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Amino Acid Deprivation Decreases Intracellular Levels of Reactive Oxygen Species in Hepatic Stellate Cells by Arriazu, Elena, Pérez de Obanos, María P., López-Zabalza, María J., Herraiz, María T., Iraburu, María J.

“…In eukaryotic cells amino acid deprivation triggers a response aimed to ensure cell survival in stress conditions. In the present work we analyzed the effects…”
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Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma by Colyn, Leticia, Bárcena‐Varela, Marina, Álvarez‐Sola, Gloria, Latasa, M. Ujue, Uriarte, Iker, Santamaría, Eva, Herranz, Jose M., Santos‐Laso, Alvaro, Arechederra, Maria, Ruiz de Gauna, Mikel, Aspichueta, Patricia, Canale, Matteo, Casadei‐Gardini, Andrea, Francesconi, Maria, Carotti, Simone, Morini, Sergio, Nelson, Leonard J., Iraburu, Maria J., Chen, Chaobo, Sangro, Bruno, Marin, Jose J.G., Martinez‐Chantar, Maria L., Banales, Jesus M., Arnes‐Benito, Robert, Huch, Meritxell, Patino, John M., Dar, Altaf A., Nosrati, Mehdi, Oyarzábal, Julen, Prósper, Felipe, Urman, Jesus, Cubero, Francisco Javier, Trautwein, Christian, Berasain, Carmen, Fernandez‐Barrena, Maite G., Avila, Matias A.

“…Background and Aims Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and…”
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Losartan inhibits the post-transcriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive rats by Varo, Nerea, Etayo, Juan C, Zalba, Guillermo, Beaumont, Javier, Iraburu, María J, Montiel, Cristina, Gil, María J, Monreal, Ignacio, Díez, Javier

“…OBJECTIVEPrevious studies have shown that as well as left ventricular hypertrophy, myocardial fibrosis develops early in rats with spontaneous hypertension…”
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3,4-Methylenedioxymethamphetamine (“Ecstasy”) induces apoptosis of cultured rat liver cells by Montiel-Duarte, Cristina, Varela-Rey, Marta, Osés-Prieto, Juan A, López-Zabalza, Marı́a Jesús, Beitia, Guadalupe, Cenarruzabeitia, Edurne, Iraburu, Marı́a J

“…“Ecstasy” (3,4-methylenedioxymethamphetamine, MDMA) has been shown to be hepatotoxic for human users, but molecular mechanisms involved in this effect remained…”
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Messenger RNA as a personalized therapy: The moment of truth for rare metabolic diseases by Córdoba, Karol M, Jericó, Daniel, Sampedro, Ana, Jiang, Lei, Iraburu, María J, Martini, Paolo G V, Berraondo, Pedro, Avila, Matías A, Fontanellas, Antonio

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Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells by Ansorena, Eduardo, Berasain, Carmen, López Zabalza, María J, Avila, Matías A, García-Trevijano, Elena R, Iraburu, María J

“…S-adenosylmethionine (AdoMet) and 5'-methylthioadenosine (MTA) exert a protective action on apoptosis induced by okadaic acid in primary rat hepatocytes but…”
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Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach by Urman, Jesús M., Herranz, José M., Uriarte, Iker, Rullán, María, Oyón, Daniel, González, Belén, Fernandez-Urién, Ignacio, Carrascosa, Juan, Bolado, Federico, Zabalza, Lucía, Arechederra, María, Alvarez-Sola, Gloria, Colyn, Leticia, Latasa, María U., Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio, Iraburu, María J., Iruarrizaga-Lejarreta, Marta, Alonso, Cristina, Sangro, Bruno, Purroy, Ana, Gil, Isabel, Carmona, Lorena, Cubero, Francisco Javier, Martínez-Chantar, María L., Banales, Jesús M., Romero, Marta R., Macias, Rocio I.R., Monte, Maria J., Marín, Jose J. G., Vila, Juan J., Corrales, Fernando J., Berasain, Carmen, Fernández-Barrena, Maite G., Avila, Matías A.

“…Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses…”
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Transforming growth factor β1 induces the expression of α1(i) procollagen mRNA by a hydrogen peroxide‐C/EBPβ‐dependent mechanism in rat hepatic stellate cells by García‐Trevijano, Elena R., Iraburu, María J., Fontana, Luis, Domínguez‐Rosales, José A., Auster, Anitra, Covarrubias‐Pinedo, Amador, Rojkind, Marcos

“…Oxidative stress plays a key role in liver fibrosis. Both inflammatory cells and activated Kupffer cells produce H2O2, an oxidant involved in the activation of…”
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