Search Results - "Iqbal, Iram Khan"

Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery by Iqbal, Iram Khan, Bajeli, Sapna, Akela, Ajit Kumar, Kumar, Ashwani

“…(Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle. With the advent of…”
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Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy by Iqbal, Iram Khan, Bajeli, Sapna, Sahu, Shivani, Bhat, Shabir Ahmad, Kumar, Ashwani

“…The deacetylase SIRT1 (sirtuin 1) has emerged as a major regulator of nucleocytoplasmic distribution of macroautophagy/autophagy marker MAP1LC3/LC3…”
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Quantification of the Metabolic Heterogeneity in Mycobacterial Cells Through the Measurement of the NADH/NAD+ Ratio Using a Genetically Encoded Sensor by Bhat, Shabir Ahmad, Iqbal, Iram Khan, Kumar, Ashwani

“…NADH/NAD levels are an indicator of the bacterial metabolic state. NAD(H) levels are maintained through coordination of pathways involved in NAD(H) synthesis…”
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Imaging the NADH:NAD + Homeostasis for Understanding the Metabolic Response of Mycobacterium to Physiologically Relevant Stresses by Bhat, Shabir A, Iqbal, Iram K, Kumar, Ashwani

“…The NADH:NAD ratio is the primary indicator of the metabolic state of bacteria. NAD(H) homeostasis is critical for (Mtb) survival and is thus considered an…”
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Abstract 3303: Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignancies by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, Babu, Dabbeeru Madhu, Shwetha, Shwetha, Manna, Ankita, Mandal, Monalisha, Panigrahi, Rituparna, Marappan, Sivapriya, Gore, Suraj T, Fairus, Mohamad, Jin, Lim Yang, Mukherjee, Subhendu, Daginakatte, Girish, Chelur, Shekar, Nellore, Kavitha, Ramachandra, Murali, Samajdar, Susanta

“…Abstract EP300 (or p300) acts as histone acetyltransferase (HAT) and transcriptional adapter or co-activator regulating transcription via chromatin remodeling…”
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Abstract 6065: Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapy by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, A R, Girish, Kamath, Aishwarya B, Mane, Deepak Dattatray, Raj A, Gouri, Reghu, Reshma, Mohapatra, Subhasmita, Marappan, Sivapriya, Gore, Suraj T, Mukherjee, Subhendu, Daginakatte, Girish, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract CBP and p300 are closely related epigenetic modulators that participate in chromatin remodeling and transcription and play an oncogenic role in a…”
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