Search Results - "Iqbal, Farwah"

Glucose withdrawal induces Endothelin 1 release with significant angiogenic effect from first trimester (FTM), but not term human umbilical cord perivascular cells (HUCPVC) by Szaraz, Peter, Mander, Poonam, Gasner, Nadav, Librach, Max, Iqbal, Farwah, Librach, Clifford

“…Background Perivascular cells (PVC) and their “progeny,” mesenchymal stromal cells (MSC), have high therapeutic potential for ischemic diseases. While hypoxia…”
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Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay by Iqbal, Farwah, Szaraz, Peter, Librach, Matthew, Gauthier-Fisher, Andrée, Librach, Clifford L

“…Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of…”
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Combination human umbilical cord perivascular and endothelial colony forming cell therapy for ischemic cardiac injury by Iqbal, Farwah, Johnston, Alexander, Wyse, Brandon, Rabani, Razieh, Mander, Poonam, Hoseini, Banafshe, Wu, Jun, Li, Ren-Ke, Gauthier-Fisher, Andrée, Szaraz, Peter, Librach, Clifford

“…Cell-based therapeutics are promising interventions to repair ischemic cardiac tissue. However, no single cell type has yet been found to be both specialized…”
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A solution to prevent secondary flow in adherent cell cultures by Szaraz, Peter, Librach, Matthew, Mander, Poonam, Hoseini, Banafshe, Librach, Max, Iqbal, Farwah, Librach, Clifford

“…High quality cell cultures require reliable laboratory practices. Today's small-scale cell culture format is dominated by circular topology vessels, with the…”
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In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Librach, Clifford L., Kenigsberg, Shlomit, Barretto, Tanya A., Iqbal, Farwah, Maghen, Leila, Librach, Matthew, Szaraz, Peter, Gauthier-Fisher, Andrée

“…Myocardial infarction (MI) causes an extensive loss of heart muscle cells and leads to congestive heart disease (CAD), the leading cause of mortality and…”
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Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease by Iqbal, Farwah, Lupieri, Adrien, Aikawa, Masanori, Aikawa, Elena

“…The transition of healthy arteries and cardiac valves into dense, cell-rich, calcified, and fibrotic tissues is driven by a complex interplay of both cellular…”
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Abstract 708: Platelet Derived Growth Factor-Beta Communication Axis is Critical for Mediating Pericyte-Endothelial Cell Interactions and Angiogenic Support in Combination Therapy of Human Umbilical Cord Perivascular Cells and Endothelial Progenitor Cells by Iqbal, Farwah, Szaraz, Peter, Librach, Clifford

“…Abstract only Introduction: First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVC) have higher cardiovascular regenerative potential compared to…”
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Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease by Iqbal, Farwah, Lupieri, Adrien, Aikawa, Masanori, Aikawa, Elena

“…The transition of healthy arteries and cardiac valves into dense, cell-rich, calcified, and fibrotic tissues is driven by a complex interplay of both cellular…”
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Abstract 660: Injury Induced Connexin 43 Expression Plays A Role In Vascular Endothelial Wound Healing by Sedovy, Meghan W, Leng, Xinyan, Iqbal, Farwah, Malek, Arya, Roberts, Kailynn, Johnstone, Scott R

“…Abstract only Vascular surgeries, such as stent placement and coronary artery bypass, damage the endothelial lining of blood vessels. Impaired healing of…”
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In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells by Szaraz, Peter, Gratch, Yarden S, Iqbal, Farwah, Librach, Clifford L

“…Myocardial infarction and the subsequent ischemic cascade result in the extensive loss of cardiomyocytes, leading to congestive heart failure, the leading…”
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Abstract 655: Protecting The Saphenous Vein Endothelium During Bypass Surgery by Sedovy, Meghan W, Leng, Xinyan, Iqbal, Farwah, Leaf, Melissa, Malek, Arya, Wyatt, David A, Choate, Cynthia W, Rowe, Joseph F, Baker, Joseph W, Johnstone, Scott R, Joseph, Mark

“…Abstract only Coronary artery bypass graft surgeries commonly use saphenous vein grafts to revascularize diseased coronary arteries. Despite surgical and…”
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Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity by Iqbal, Farwah, Schlotter, Florian, Becker-Greene, Dakota, Lupieri, Adrien, Goettsch, Claudia, Hutcheson, Joshua D, Rogers, Maximillian A, Itoh, Shinsuke, Halu, Arda, Lee, Lang Ho, Blaser, Mark C, Mlynarchik, Andrew K, Hagita, Sumihiko, Kuraoka, Shiori, Chen, Hao Yu, Engert, James C, Passos, Livia S A, Jha, Prabhash K, Osborn, Eric A, Jaffer, Farouc A, Body, Simon C, Robson, Simon C, Thanassoulis, George, Aikawa, Masanori, Singh, Sasha A, Sonawane, Abhijeet R, Aikawa, Elena

“…Abstract Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and…”
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Connexin 43 across the Vasculature: Gap Junctions and Beyond by Sedovy, Meghan W, Leng, Xinyan, Leaf, Melissa R, Iqbal, Farwah, Payne, Laura Beth, Chappell, John C, Johnstone, Scott R

“…Connexin 43 (Cx43) is essential to the function of the vasculature. Cx43 proteins form gap junctions that allow for the exchange of ions and molecules between…”
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ApoC-III is a novel inducer of calcification in human aortic valves by Schlotter, Florian, de Freitas, Renata C.C., Rogers, Maximillian A., Blaser, Mark C., Wu, Pin-Jou, Higashi, Hideyuki, Halu, Arda, Iqbal, Farwah, Andraski, Allison B., Rodia, Cayla N., Kuraoka, Shiori, Wen, Jennifer R., Creager, Michael, Pham, Tan, Hutcheson, Joshua D., Body, Simon C., Kohan, Alison B., Sacks, Frank M., Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena

“…Calcific aortic valve disease (CAVD) occurs when subpopulations of valve cells undergo specific differentiation pathways, promoting tissue fibrosis and…”
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Abstract 410: A Novel Combination Therapy Using First Trimester Human Umbilical Cord-Derived Mesenchymal Stromal Cells and Endothelial Progenitor Cells Significantly Improves Angiogenesis and Cardiac Recovery Following Myocardial Infarction by Iqbal, Farwah, Johnston, Alexander, Mander, Poonam, Wyse, Brandon, Wu, Jun, Li, Ren-Ke, Szaraz, Peter, Librach, Clifford

“…Abstract only Introduction: Umbilical cord-derived MSC show pericyte-like characteristics and demonstrate significant angiogenic potential via paracrine and…”
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Characterization of Potential Mechanisms That Render the Combination of First Trimester Umbilical Cord-derived Perivascular Cells (FTM HUCPVC) and Endothelial Progenitor Cells (EPC) a Promising Cellular Therapeutic Strategy Following Ischemic Cardiac Injury by Iqbal, Farwah

“…Heart disease is the main cause of mortality worldwide. The available treatments are limited, high risk and often inefficient. Cell-based therapies are being…”
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Abstract 717: CGMP Expanded First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVC) Induce Significant Angiogenesis, Myocardial Regeneration and Sustained Functional Recovery Exceeding Older MSC Sources in the Rat Myocardial Infarction (MI) Model by Péter, Száraz, Johnston, Alexander, Iqbal, Farwah, Hoseini, Banafshe, Lucato, Alexandra, Mander, Poonam, Wu, Jun, Li, Ren-Ke, Librach, Clifford

“…Abstract only Introduction: FTM HUCPVC are a novel source of young, immunoprivileged mesenchymal stromal cells (MSC). FTM HUCPVC demonstrate significant…”
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Abstract 358: First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCs) Maintain High Expression Levels of Angiogenic Factors and Have Superior Pro-angiogenic Effects on Endothelial Networks When Compared to Term HUCPVCs and BMSCs in an ex-vivo Rat Aortic Ring Assay by Iqbal, Farwah, Szaraz, Peter, Kenigsberg, Shlomit, Gauthier-Fisher, Andree, Librach, Clifford

“…Abstract only Introduction: Features of an ideal cell type, that would be conducive to vascular regeneration include (1) expression of pro-angiogenic genes (2)…”
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Abstract 31: First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCs) Show Superior Angiogenic Potential in Angiogenic Potency Assays When Compared to Term HUCPVCs and Bone Marrow Stromal Cells by Iqbal, Farwah, Szaraz, Peter, Wu, Jun, Gauthier-Fisher, Andree, Li, Ren-Ke, Librach, Clifford

“…Abstract only Introduction: Cell therapy employing pro-angiogenic cell types is a promising option for promoting revascularization of ischemic tissues. First…”
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The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro by Iqbal, Farwah, Gratch, Yarden S, Szaraz, Peter, Librach, Clifford L

“…Angiogenesis is a complex, highly regulated process responsible for providing and maintaining adequate tissue perfusion. Insufficient vasculature maintenance…”
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