Search Results - "Iqbal, Aman"

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability by Houliston, R. Scott, Lemak, Alexander, Iqbal, Aman, Ivanochko, Danton, Duan, Shili, Kaustov, Lilia, Ong, Michelle S., Fan, Lixin, Senisterra, Guillermo, Brown, Peter J., Wang, Yun-Xing, Arrowsmith, Cheryl H.

“…UHRF1 is a key mediator of inheritance of epigenetic DNA methylation patterns during cell division and is a putative target for cancer therapy. Recent studies…”
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A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II by Liu, Yanli, Iqbal, Aman, Li, Weiguo, Ni, Zuyao, Wang, Yalong, Ramprasad, Jurupula, Abraham, Karan Joshua, Zhang, Mengmeng, Zhao, Dorothy Yanling, Qin, Su, Loppnau, Peter, Jiang, Honglv, Guo, Xinghua, Brown, Peter J., Zhen, Xuechu, Xu, Guoqiang, Mekhail, Karim, Ji, Xingyue, Bedford, Mark T., Greenblatt, Jack F., Min, Jinrong

“…Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain,…”
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Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2‑Oxoglutarate Dependent Oxygenases by Tarhonskaya, Hanna, Szöllössi, Andrea, Leung, Ivanhoe K. H, Bush, Jacob T, Henry, Luc, Chowdhury, Rasheduzzaman, Iqbal, Aman, Claridge, Timothy D. W, Schofield, Christopher J, Flashman, Emily

“…Deacetoxycephalosporin C synthase (DAOCS) catalyzes the oxidative ring expansion of penicillin N (penN) to give deacetoxycephalosporin C (DAOC), which is the…”
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The trend of measles in Afghanistan by Nishat, Homeira, Aman, Mohammad Iqbal, Ibrahimi, Farahnaz, Zahed, Ajmal, Khader, Yousef, Shaheen, Malak A

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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP) by Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E

“…XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways…”
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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP by Chessari, Gianni, Buck, Ildiko M, Day, James E. H, Day, Philip J, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Miller, Darcey, Reader, Michael, Rees, David C, Rich, Sharna J, Tamanini, Emiliano, Vitorino, Marc, Ward, George A, Williams, Pamela A, Williams, Glyn, Wilsher, Nicola E, Woolford, Alison J.-A

“…Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis and pro-survival signaling pathways whose deregulation is often associated with…”
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Identification and characterization of the first fragment hits for SETDB1 Tudor domain by Mader, Pavel, Mendoza-Sanchez, Rodrigo, Iqbal, Aman, Dong, Aiping, Dobrovetsky, Elena, Corless, Victoria B., Liew, Sean K., Houliston, Scott R., De Freitas, Renato Ferreira, Smil, David, Sena, Carlo C. Dela, Kennedy, Steven, Diaz, Diego B., Wu, Hong, Dombrovski, Ludmila, Allali-Hassani, Abdellah, Min, Jinrong, Schapira, Matthieu, Vedadi, Masoud, Brown, Peter J., Santhakumar, Vijayaratnam, Yudin, Andrei K., Arrowsmith, Cheryl H.

“…[Display omitted] SET domain bifurcated protein 1 (SETDB1) is a human histone-lysine methyltransferase which is amplified in human cancers and was shown to be…”
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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors by Murray, Christopher W, Berdini, Valerio, Buck, Ildiko M, Carr, Maria E, Cleasby, Anne, Coyle, Joseph E, Curry, Jayne E, Day, James E. H, Day, Phillip J, Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y. W, Martins, Vanessa, Mortenson, Paul N, Munck, Joanne M, Page, Lee W, Patel, Sahil, Roomans, Susan, Smith, Kirsten, Tamanini, Emiliano, Saxty, Gordon

“…The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We…”
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Removing user fees for basic health services: a pilot study and national roll-out in Afghanistan by Steinhardt, Laura C, Aman, Iqbal, Pakzad, Iqbalshah, Kumar, Binay, Singh, Lakhwinder P, Peters, David

“…Background User fees for primary care tend to suppress utilization, and many countries are experimenting with fee removal. Studies show that additional inputs…”
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Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway by Valegård, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, Généreux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger, McDonough, Michael A.

“…Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and…”
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Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates by Iqbal, Aman, Clifton, Ian J, Chowdhury, Rasheduzzaman, Ivison, David, Domene, Carmen, Schofield, Christopher J

“…Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an…”
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Abstract 2944: AT-IAP, a dual cIAP1 and XIAP antagonist with oral antitumor activity in melanoma models by Chessari, Gianni, Maria, Ahn, Buck, Ildiko, Chiarparin, Elisabetta, Coyle, Joe, Day, James, Frederickson, Martyn, Griffiths-Jones, Charlotte, Hearn, Keisha, Howard, Steven, Heightman, Tom, Hillmann, Petra, Iqbal, Aman, Johnson, Christopher N., Lewis, Jon, Martins, Vanessa, Munck, Joanne, Reader, Mike, Page, Lee, Hopkins, Anna, Millemaggi, Alessia, Richardson, Caroline, Saxty, Gordon, Smyth, Tomoko, Tamanini, Emiliano, Thompson, Neil, Ward, George, Williams, Glyn, Williams, Pamela, Wilsher, Nicola, Woolford, Alison

“…Abstract Melanoma is a highly aggressive malignancy with an exceptional ability to develop resistance and no curative therapy is available for patients with…”
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Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway by Iqbal, Aman, Arunlanantham, Haren, Brown Jr, Tom, Chowdhury, Rasheduzzaman, Clifton, Ian J., Kershaw, Nadia J., Hewitson, Kirsty S., McDonough, Michael A., Schofield, Christopher J.

“…(3R,5R)‐Clavulanic acid (CA) is a clinically important inhibitor of Class A β‐lactamases. Sequence comparisons suggest that orf14 of the clavulanic acid…”
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Abstract 2018: Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discovery by Chessari, Gianni, Buck, Ildiko, Chiarparin, Elisabetta, Day, James, Frederickson, Martyn, Hearn, Keisha, Heightman, Tom, Hillmann, Petra, Iqbal, Aman, Johnson, Chris, Lewis, Jon, Martins, Vanessa, Richardson, Caroline, Smyth, Tomoko, Tamanini, Emiliano, Thompson, Neil, Ward, George, Williams, Glyn, Williams, Pamela, Wilsher, Nicola, Woolford, Alison

“…Abstract XIAP and cIAP1 are members of the inhibitor of apoptosis (IAP) protein family. Both proteins have the ability to attenuate apoptosis induced through…”
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Crystal Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid by Mackenzie, Alasdair K., Valegård, Karin, Iqbal, Aman, Caines, Matthew E.C., Kershaw, Nadia J., Jensen, Susan E., Schofield, Christopher J., Andersson, Inger

“…Clavulanic acid (CA) is a clinically important β-lactamase inhibitor that is produced by fermentation of Streptomyces clavuligerus. The CA biosynthesis pathway…”
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Anatomy of a Simple Acyl Intermediate in Enzyme Catalysis: Combined Biophysical and Modeling Studies on Ornithine Acetyl Transferase by Iqbal, Aman, Clifton, Ian J, Bagonis, Maria, Kershaw, Nadia J, Domene, Carmen, Claridge, Timothy D. W, Wharton, Christopher W, Schofield, Christopher J

“…Acyl-enzyme complexes are intermediates in reactions catalyzed by many hydrolases and related enzymes which employ nucleophilic catalysis. However, most of the…”
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Studies on an n-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis by Iqbal, Aman

“…(3R,5R)-Clavulanic acid is a clinically important inhibitor of Class A β-lactamases. Progress has been made in to establishing the steps of clavulanic acid…”
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Epidemiological profile of Crimean Congo Hemorrhagic Fever (CCHF) in Afghanistan: a teaching-case study by Amini, Wahida, Aman, Mohammad Iqbal, Khader, Yousef, Shaheen, Malik

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