Search Results - "Ipseiz, Natacha"

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation by Faas, Maria, Ipseiz, Natacha, Ackermann, Jochen, Culemann, Stephan, Grüneboom, Anika, Schröder, Fenja, Rothe, Tobias, Scholtysek, Carina, Eberhardt, Martin, Böttcher, Martin, Kirchner, Philipp, Stoll, Cornelia, Ekici, Arif, Fuchs, Maximilian, Kunz, Meik, Weigmann, Benno, Wirtz, Stefan, Lang, Roland, Hofmann, Joerg, Vera, Julio, Voehringer, David, Michelucci, Alessandro, Mougiakakos, Dimitrios, Uderhardt, Stefan, Schett, Georg, Krönke, Gerhard

“…Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and tissue repair. However, molecular pathways that govern their…”
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Macrophage reprogramming for therapy by Bart, Valentina M. T., Pickering, Robert J., Taylor, Philip R., Ipseiz, Natacha

“…Summary Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To…”
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The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation by Rothe, Tobias, Ipseiz, Natacha, Faas, Maria, Lang, Stefanie, Perez-Branguli, Francesc, Metzger, Daniel, Ichinose, Hiroshi, Winner, Beate, Schett, Georg, Krönke, Gerhard

“…Microglia cells fulfill key homeostatic functions and essentially contribute to host defense within the CNS. Altered activation of microglia, in turn, has been…”
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The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells by Ipseiz, Natacha, Uderhardt, Stefan, Scholtysek, Carina, Steffen, Martin, Schabbauer, Gernot, Bozec, Aline, Schett, Georg, Krönke, Gerhard

“…Uptake of apoptotic cells (ACs) by macrophages ensures the nonimmunogenic clearance of dying cells, as well as the maintenance of self-tolerance to AC-derived…”
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The Role of Macrophages During Zebrafish Injury and Tissue Regeneration Under Infectious and Non-Infectious Conditions by Bohaud, Candice, Johansen, Matt D, Jorgensen, Christian, Ipseiz, Natacha, Kremer, Laurent, Djouad, Farida

“…The future of regenerative medicine relies on our understanding of the mechanistic processes that underlie tissue regeneration, highlighting the need for…”
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Therapeutic targeting of chronic kidney disease-associated DAMPs differentially contributing to vascular pathology by Mazzarino, Morgane, Cetin, Esra, Bartosova, Maria, Marinovic, Iva, Ipseiz, Natacha, Hughes, Timothy R., Schmitt, Claus Peter, Ramji, Dipak P., Labéta, Mario O., Raby, Anne-Catherine

“…Chronic Kidney Disease (CKD) is associated with markedly increased cardiovascular (CV) morbidity and mortality. Chronic inflammation, a hallmark of both CKD…”
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The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions by Bohaud, Candice, Johansen, Matt D., Jorgensen, Christian, Kremer, Laurent, Ipseiz, Natacha, Djouad, Farida

“…Several infectious pathologies in humans, such as tuberculosis or SARS-CoV-2, are responsible for tissue or lung damage, requiring regeneration. The…”
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PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass by Müller, Dorothea I. H., Stoll, Cornelia, Palumbo-Zerr, Katrin, Böhm, Christina, Krishnacoumar, Brenda, Ipseiz, Natacha, Taubmann, Jule, Zimmermann, Max, Böttcher, Martin, Mougiakakos, Dimitrios, Tuckermann, Jan, Djouad, Farida, Schett, Georg, Scholtysek, Carina, Krönke, Gerhard

“…Bone turnover, which is determined by osteoclast-mediated bone resorption and osteoblast-mediated bone formation, represents a highly energy consuming process…”
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NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover by Scholtysek, Carina, Ipseiz, Natacha, Böhm, Christina, Krishnacoumar, Brenda, Stenzel, Martin, Czerwinski, Tina, Palumbo‐Zerr, Katrin, Rothe, Tobias, Weidner, Daniela, Klej, Alexandra, Stoll, Cornelia, Distler, Jörg, Tuckermann, Jan, Herrmann, Martin, Fabry, Ben, Goldmann, Wolfgang H, Schett, Georg, Krönke, Gerhard

“…ABSTRACT NR4A1 (Nur77 or NGFI‐B), an orphan member of the nuclear receptor superfamily, has been identified as a key regulator of the differentiation and…”
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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors by Krishnacoumar, Brenda, Stenzel, Martin, Garibagaoglu, Hilal, Omata, Yasunori, Sworn, Rachel L, Hofmann, Thea, Ipseiz, Natacha, Czubala, Magdalena A, Steffen, Ulrike, Maccataio, Antonio, Stoll, Cornelia, Böhm, Christina, Herrmann, Martin, Uderhardt, Stefan, Jenkins, Robert H, Taylor, Philip R, Grüneboom, Anika, Zaiss, Mario M, Schett, Georg, Krönke, Gerhard, Scholtysek, Carina

“…Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts…”
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Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway by Ipseiz, Natacha, Pickering, Robert J, Rosas, Marcela, Tyrrell, Victoria J, Davies, Luke C, Orr, Selinda J, Czubala, Magdalena A, Fathalla, Dina, Robertson, Avril AB, Bryant, Clare E, O'Donnell, Valerie, Taylor, Philip R

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Moonlighting osteoclasts as undertakers of apoptotic cells by Harre, Ulrike, Keppeler, Hildegard, Ipseiz, Natacha, Derer, Anja, Poller, Kerstin, Aigner, Michael, Schett, Georg, Herrmann, Martin, Lauber, Kirsten

“…Rapid clearance of apoptotic cells, frequently referred to as efferocytosis, is crucial for the maintenance of tissue homeostasis and the prevention of…”
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Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors by Ipseiz, Natacha, Czubala, Magdalena A., Bart, Valentina M.T., Davies, Luke C., Jenkins, Robert H., Brennan, Paul, Taylor, Philip R.

“…Tissue-resident macrophages exhibit specialized phenotypes dependent on their in vivo physiological niche. Investigation of their function often relies upon…”
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Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors by Ipseiz, Natacha, Czubala, Magdalena A., Bart, Valentina M.T., Davies, Luke C., Jenkins, Robert H., Brennan, Paul, Taylor, Philip R.

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Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis by Ipseiz, Natacha, Scholtysek, Carina, Culemann, Stephan, Krönke, Gerhard

“…Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of…”
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Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche by Luo, Yubin, Chen, Guang-Liang, Hannemann, Nicole, Ipseiz, Natacha, Krönke, Gerhard, Bäuerle, Tobias, Munos, Luis, Wirtz, Stefan, Schett, Georg, Bozec, Aline

“…The effect of metabolic stress on the bone marrow microenvironment is poorly defined. We show that high-fat diet (HFD) decreased long-term Lin−Sca-1+c-Kit+…”
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Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease by Pfeifle, R., Nandakumar, Kutty Selva, Krönke, G.

“…The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23…”
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Regulation of autoantibody activity by the IL-23-T H 17 axis determines the onset of autoimmune disease by Pfeifle, René, Rothe, Tobias, Ipseiz, Natacha, Scherer, Hans U, Culemann, Stephan, Harre, Ulrike, Ackermann, Jochen A, Seefried, Martina, Kleyer, Arnd, Uderhardt, Stefan, Haugg, Benjamin, Hueber, Axel J, Daum, Patrick, Heidkamp, Gordon F, Ge, Changrong, Böhm, Sybille, Lux, Anja, Schuh, Wolfgang, Magorivska, Iryna, Nandakumar, Kutty S, Lönnblom, Erik, Becker, Christoph, Dudziak, Diana, Wuhrer, Manfred, Rombouts, Yoann, Koeleman, Carolien A, Toes, René, Winkler, Thomas H, Holmdahl, Rikard, Herrmann, Martin, Blüml, Stephan, Nimmerjahn, Falk, Schett, Georg, Krönke, Gerhard

“…The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23…”
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Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway by Ipseiz, Natacha, Pickering, Robert J, Rosas, Marcela, Tyrrell, Victoria J, Davies, Luke C, Orr, Selinda J, Czubala, Magdalena A, Fathalla, Dina, Robertson, Avril AB, Bryant, Clare E, O'Donnell, Valerie, Taylor, Philip R

“…The alarm cytokine interleukin‐1β (IL‐1β) is a potent activator of the inflammatory cascade following pathogen recognition. IL‐1β production typically requires…”
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Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow by Haberland, Konrad, Ackermann, Jochen A., Ipseiz, Natacha, Culemann, Stephan, Pracht, Katharina, Englbrecht, Matthias, Jäck, Hans‐Martin, Schett, Georg, Schuh, Wolfgang, Krönke, Gerhard

“…Eosinophils were reported to serve as an essential component of the plasma cell niche within the bone marrow. As the potential contribution of eosinophils to…”
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