Search Results - "Ippolito, Rosaria"
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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
Published in Developmental cell (13-09-2021)“…Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide…”
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Journal Article -
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Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
Published in Science signaling (02-04-2019)“…Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the…”
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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
Published in Cell reports (Cambridge) (28-01-2020)“…Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors…”
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Short-term molecular consequences of chromosome mis-segregation for genome stability
Published in Nature communications (11-03-2023)“…Chromosome instability (CIN) is the most common form of genome instability and is a hallmark of cancer. CIN invariably leads to aneuploidy, a state of…”
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Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
Published in Nature communications (09-09-2024)“…Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we…”
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Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents
Published in DNA Damage and Chromosomal Instability (2024)“…Aneuploidy is a condition in which cells have an abnormal number of chromosomes that is not a multiple of the haploid complement. It is known that aneuploidy…”
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Book Chapter Journal Article -
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The Reinvention of ^}\mathbf in an Industrial Area with the Application of a Preventive Radiometric Risk Management Procedure without the Use of Radiometric Portals or Judicial Collaborators
Published in 2024 IEEE International Workshop on Metrology for Living Environment (MetroLivEnv) (12-06-2024)“…A procedure for the containment of potential radiological risk systematically applied to sampling activities and site visits in areas lacking environmental…”
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Conference Proceeding -
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A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
Published in Science (American Association for the Advancement of Science) (30-08-2024)“…Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements…”
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Abstract 413: Aneuploid cells depend on the RAF/MEK/ERK pathway and on RNA degradation for overcoming DNA damage and transcriptional burden
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Understanding the broad implications of aneuploidy at molecular, cellular, and…”
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Journal Article -
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Exploring the Impact of a Structured Educational Approach on Peristomal Skin Complications: An Interim Analysis
Published in Healthcare (Basel) (10-09-2024)“…This study, employing an interim analysis, investigates the effects of the Dermamecum protocol, a structured educational and tailored approach that stratifies…”
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Journal Article