Search Results - "Ippolito, Joseph A"

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV‑2 by Ghahremanpour, Mohammad M, Tirado-Rives, Julian, Deshmukh, Maya, Ippolito, Joseph A, Zhang, Chun-Hui, Cabeza de Vaca, Israel, Liosi, Maria-Elena, Anderson, Karen S, Jorgensen, William L

“…A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus…”
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Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV‑2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations by Zhang, Chun-Hui, Stone, Elizabeth A, Deshmukh, Maya, Ippolito, Joseph A, Ghahremanpour, Mohammad M, Tirado-Rives, Julian, Spasov, Krasimir A, Zhang, Shuo, Takeo, Yuka, Kudalkar, Shalley N, Liang, Zhuobin, Isaacs, Farren, Lindenbach, Brett, Miller, Scott J, Anderson, Karen S, Jorgensen, William L

“…Starting from our previous finding of 14 known drugs as inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have…”
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Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit by Ippolito, Joseph A, Kanyo, Zoltan F, Wang, Deping, Franceschi, Francois J, Moore, Peter B, Steitz, Thomas A, Duffy, Erin M

“…The oxazolidinone antibacterials target the 50S subunit of prokaryotic ribosomes. To gain insight into their mechanism of action, the crystal structure of the…”
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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV‑2 to Low-Nanomolar Antiviral Potency by Zhang, Chun-Hui, Spasov, Krasimir A, Reilly, Raquel A, Hollander, Klarissa, Stone, Elizabeth A, Ippolito, Joseph A, Liosi, Maria-Elena, Deshmukh, Maya G, Tirado-Rives, Julian, Zhang, Shuo, Liang, Zhuobin, Miller, Scott J, Isaacs, Farren, Lindenbach, Brett D, Anderson, Karen S, Jorgensen, William L

“…Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018 μM for…”
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RNA Tertiary Interactions in the Large Ribosomal Subunit: The A-Minor Motif by Nissen, Poul, Ippolito, Joseph A., Ban, Nenad, Moore, Peter B., Steitz, Thomas A.

“…Analysis of the 2.4-Å resolution crystal structure of the large ribosomal subunit from Haloarcula marismortui reveals the existence of an abundant and…”
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The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit by Hansen, Jeffrey L., Ippolito, Joseph A., Ban, Nenad, Nissen, Poul, Moore, Peter B., Steitz, Thomas A.

“…Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and…”
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Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase by Frey, Kathleen M, Bertoletti, Nicole, Chan, Albert H, Ippolito, Joseph A, Bollini, Mariela, Spasov, Krasimir A, Jorgensen, William L, Anderson, Karen S

“…Reverse transcriptase (RT) from the human immunodeficiency virus continues to be an attractive drug target for antiretroviral therapy. June 2022 will…”
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Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance by SKRIPKIN, Eugene, MCCONNELL, Timothy S, DEVITO, Joseph, LAWRENCE, Laura, IPPOLITO, Joseph A, DUFFY, Erin M, SUTCLIFFE, Joyce, FRANCESCHI, Francois

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Use of the h-Index in Academic Orthopaedic Surgery by Bastian, Sevag, Ippolito, Joseph A., Lopez, Santiago A., Eloy, Jean Anderson, Beebe, Kathleen S.

“…The Hirsch index (h-index), widely considered a valuable measure of assessing academic productivity, has been studied in various medical and surgical…”
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The relative citation ratio (RCR) as a novel bibliometric among 2511 academic orthopedic surgeons by Gupta, Arjun, Meeter, Alexandra, Norin, Jorden, Ippolito, Joseph A., Beebe, Kathleen S.

“…Objectively measuring research output is important for grant awards, promotion, and tenure, or self‐evaluation of productivity. However, certain shortcomings…”
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The Effect of Sex on Orthopaedic Surgeon Income by Beebe, Kathleen S., Krell, Ethan S., Rynecki, Nicole D., Ippolito, Joseph A.

“…Several studies have identified discrepancies in salary between male and female surgeons. Our aim was to investigate the impact of sex on an orthopaedic…”
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Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease by Deshmukh, Maya G., Ippolito, Joseph A., Zhang, Chun-Hui, Stone, Elizabeth A., Reilly, Raquel A., Miller, Scott J., Jorgensen, William L., Anderson, Karen S.

“…There is a clinical need for direct-acting antivirals targeting SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, to complement current…”
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Supplemental Bone Grafting in Giant Cell Tumor of the Extremity Reduces Nononcologic Complications by Benevenia, Joseph, Rivero, Steven M., Moore, Jeffrey, Ippolito, Joseph A., Siegerman, Daniel A., Beebe, Kathleen S., Patterson, Francis R.

“…Background Giant cell tumors (GCTs) are treated with resection curettage and adjuvants followed by stabilization. Complications include recurrence, fracture,…”
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Larger stem to bone diameter ratio predicts lower cemented endoprosthesis failure by Kadkoy, Yazan, Ippolito, Joseph A., Schneider, Gregory, Thomson, Jennifer, Park, Claire, Dias, Rosamaria, Beebe, Kathleen S., Patterson, Francis R., Benevenia, Joseph

“…Background and Objectives With continued advances in treatment options, patients with endoprosthetic reconstruction are living longer and consequently relying…”
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A Preoperative Scale for Determining Surgical Readmission Risk After Total Knee Arthroplasty by Siracuse, Brianna L., Ippolito, Joseph A., Gibson, Peter D., Ohman-Strickland, Pamela A., Beebe, Kathleen S.

“…Total knee arthroplasty (TKA) is one of the most common orthopaedic procedures performed in the U.S. The purpose of this study was to develop and verify a…”
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Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands by Liosi, Maria-Elena, Ippolito, Joseph A., Henry, Sean P., Krimmer, Stefan G., Newton, Ana S., Cutrona, Kara J., Olivarez, Rene A., Mohanty, Jyotidarsini, Schlessinger, Joseph, Jorgensen, William L.

“…JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of…”
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Injuries sustained during high intensity interval training: are modern fitness trends contributing to increased injury rates? by Rynecki, Nicole D., Siracuse, Brianna L., Ippolito, Joseph A., Beebe, Kathleen S.

“…BACKGROUND: Over the past decade, interest in high intensity interval training (HIIT) has increased considerably. The objective of this study was to determine…”
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Identifying Patients at Risk for Venous Thromboembolic Events After Isolated Upper Extremity Trauma: A Predictive Scale by Ippolito, Joseph A, Siracuse, Brianna L, Galloway, Joseph D, Ahmed, Irfan, Vosbikian, Michael M

“…Previous studies have defined risk factors for development of venous thromboembolisms (VTEs) among patients with lower extremity orthopedic trauma. Limited…”
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Nonsurgical Treatment of De Quervain Tenosynovitis: A Prospective Randomized Trial by Ippolito, Joseph A., Hauser, Spencer, Patel, Jay, Vosbikian, Michael, Ahmed, Irfan

“…Background: De Quervain tenosynovitis is commonly seen in patients who perform repetitive wrist ulnar deviation with thumb abduction and extension. Previous…”
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Hoverboards: A New Cause of Pediatric Morbidity by Siracuse, Brianna L, Ippolito, Joseph A, Gibson, Peter D, Beebe, Kathleen S

“…Abstract Introduction The hoverboard, a self-balancing powered scooter, was introduced to the market in 2015 and quickly became one of the most popular…”
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