Search Results - "Ip, Jonathan"

Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing by To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Chan, Wan-Mui, Tam, Anthony Raymond, Fong, Carol Ho-Yan, Yuan, Shuofeng, Tsoi, Hoi-Wah, Ng, Anthony Chin-Ki, Lee, Larry Lap-Yip, Wan, Polk, Tso, Eugene Yuk-Keung, To, Wing-Kin, Tsang, Dominic Ngai-Chong, Chan, Kwok-Hung, Huang, Jian-Dong, Kok, Kin-Hang, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung

“…Abstract Background Waning immunity occurs in patients who have recovered from Coronavirus Disease 2019 (COVID-19). However, it remains unclear whether true…”
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Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients by Lu, Lu, Mok, Bobo Wing Yee, Chen, Lin Lei, Chan, Jacky Man Chun, Tsang, Owen Tak Yin, Lam, Bosco Hoi Shiu, Chuang, Vivien Wai Man, Chu, Allen Wing Ho, Chan, Wan Mui, Ip, Jonathan Daniel, Chan, Brian Pui Chun, Zhang, Ruiqi, Yip, Cyril Chik Yan, Cheng, Vincent Chi Chung, Chan, Kwok Hung, Jin, Dong Yan, Hung, Ivan Fan Ngai, Yuen, Kwok Yung, Chen, Honglin, To, Kelvin Kai Wang

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant, designated as a variant of concern by the World Health…”
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SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells by Zhao, Hanjun, Lu, Lu, Peng, Zheng, Chen, Lin-Lei, Meng, Xinjin, Zhang, Chuyuan, Ip, Jonathan Daniel, Chan, Wan-Mui, Chu, Allen Wing-Ho, Chan, Kwok-Hung, Jin, Dong-Yan, Chen, Honglin, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…The novel SARS-CoV-2 Omicron variant (B.1.1.529), first found in early November 2021, has sparked considerable global concern and it has >50 mutations, many of…”
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Investigation of air dispersal during a rhinovirus outbreak in a pediatric intensive care unit by Wong, Shuk-Ching, Yip, Cyril C.-Y., Chen, Jonathan H.-K., Yuen, Lithia L.-H., AuYeung, Christine H.-Y., Chan, Wan-Mui, Chu, Allen W.-H., Leung, Rhoda C.-Y., Ip, Jonathan D., So, Simon Y.-C., Yuen, Kwok-Yung, To, Kelvin K.-W., Cheng, Vincent C.-C.

“…While airborne transmission of rhinovirus is recognized in indoor settings, its role in hospital transmission remains unclear. We investigated an outbreak of…”
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Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong by Chen, Lin-Lei, Abdullah, Syed Muhammad Umer, Chan, Wan-Mui, Chan, Brian Pui-Chun, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Lu, Lu, Zhang, Xiaojuan, Zhao, Yan, Chuang, Vivien Wai-Man, Au, Albert Ka-Wing, Cheng, Vincent Chi-Chung, Sridhar, Siddharth, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, Chan, Kwok-Hung, To, Kelvin Kai-Wang

“…Monitoring population protective immunity against SARS-CoV-2 variants is critical for risk assessment. We hypothesize that Hong Kong’s explosive Omicron BA.2…”
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Development and evaluation of a conventional RT‐PCR for differentiating emerging influenza B/Victoria lineage viruses with hemagglutinin amino acid deletion from B/Yamagata lineage viruses by Chan, Wan‐Mui, Wong, Lok‐Hin, So, Chun‐Fung, Chen, Lin‐Lei, Wu, Wai‐Lan, Ip, Jonathan D., Lam, Athene Hoi‐Ying, Yip, Cyril C. Y., Yuen, Kwok‐Yung, To, Kelvin K. W.

“…Background Recent influenza B/Victoria lineage viruses contain amino acid deletions at positions 162 to 164 of the haemagglutinin (HA) protein. These amino…”
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Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains by Chen, Lin-Lei, Wu, Wai-Lan, Chan, Wan-Mui, Fong, Carol H Y, Ng, Anthony C K, Ip, Jonathan D, Lu, Lu, Dissanayake, Thrimendra K, Ding, Xixia, Cai, Jian-Piao, Zhang, Anna J X, Tam, Sidney, Hung, Ivan F N, Chan, Kwok-Hung, Yuen, Kwok-Yung, To, Kelvin K W

“…Seasonal influenza virus epidemics have a major impact on healthcare systems. Data on population susceptibility to emerging influenza virus strains during the…”
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Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2 by Zhao, Hanjun, To, Kelvin K. W., Lam, Hoiyan, Zhou, Xinxin, Chan, Jasper Fuk-Woo, Peng, Zheng, Lee, Andrew C. Y., Cai, Jianpiao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chan, Chris Chung-Sing, Yeung, Man Lung, Zhang, Anna Jinxia, Chu, Allen Wing Ho, Jiang, Shibo, Yuen, Kwok-Yung

“…Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R…”
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Emerging SARS-CoV-2 variants expand species tropism to murines by Shuai, Huiping, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Yoon, Chaemin, Hu, Jing-Chu, Wen, Lei, Hu, Bingjie, Yang, Dong, Wang, Yixin, Hou, Yuxin, Huang, Xiner, Chai, Yue, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Lu, Zhang, Rui-Qi, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Hu, Ye-Fan, Cai, Jian-Piao, Chan, Kwok-Hung, Zhou, Jie, Sridhar, Siddharth, Zhang, Bao-Zhong, Yuan, Shuofeng, Zhang, Anna Jinxia, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin

“…Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-CoV-2 variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike…”
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Humoral and cellular immunity against different SARS-CoV-2 variants in patients with chronic kidney disease by Yap, Desmond Yat-Hin, Fong, Carol Ho-Yan, Zhang, Xiaojuan, Ip, Jonathan Daniel, Chan, Wan-Mui, Chu, Allen Wing-Ho, Chen, Lin-Lei, Zhao, Yan, Chan, Brian Pui-Chun, Luk, Kristine Shik, Cheng, Vincent Chi-Chung, Chan, Tak-Mao, To, Kelvin Kai-Wang

“…Chronic kidney disease (CKD) patients are at higher risk of severe COVID-19. Humoral and cellular immunity from prior infection or vaccination are important…”
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Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19 by Wong, Shuk-Ching, Au, Albert Ka-Wing, Chen, Hong, Yuen, Lithia Lai-Ha, Li, Xin, Lung, David Christopher, Chu, Allen Wing-Ho, Ip, Jonathan Daniel, Chan, Wan-Mui, Tsoi, Hoi-Wah, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Cheng, Vincent Chi-Chung

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Development and Evaluation of an In-House Real-Time RT-PCR Targeting nsp10 Gene for SARS-CoV-2 Detection by Yip, Cyril Chik-Yan, Poon, Jane Hau-Ching, Leung, Kit-Hang, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…The emergence of SARS-CoV-2 mutations poses significant challenges to diagnostic tests, as these mutations can reduce the sensitivity of commonly used RT-PCR…”
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Loss of orf3b in the circulating SARS-CoV-2 strains by Lam, Joy-Yan, Yuen, Chun-Kit, Ip, Jonathan Daniel, Wong, Wan-Man, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Kok, Kin-Hang

“…The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since December 2019 with more than 35 million laboratory confirmed human infections…”
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The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum by Lu, Lu, Chu, Allen Wing-Ho, Zhang, Ricky Ruiqi, Chan, Wan-Mui, Ip, Jonathan Daniel, Tsoi, Hoi-Wah, Chen, Lin-lei, Cai, Jian-Piao, Lung, David Christopher, Tam, Anthony Raymond, Yau, Yat-Sun, Kwan, Mike Yat-Wah, To, Wing-Kin, Tsang, Owen Tak-Yin, Lee, Larry Lap-Yip, Yi, Haisu, Ip, Tak-Chuen, Poon, Rosana Wing-Shan, Siu, Gilman Kit-Hang, Mok, Bobo Wing-Yee, Cheng, Vincent Chi-Chung, Chan, Kwok Hung, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, To, Kelvin Kai-Wang

“…Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of N501Y on neutralizing…”
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Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells by Ip, Jonathan, Canham, Paul, Choo, K H Andy, Inaba, Yoshimi, Jacobs, Shelley A, Kalitsis, Paul, Mattiske, Deidre M, Ng, Jane, Saffery, Richard, Wong, Nicholas C, Wong, Lee H, Mann, Jeffrey R

“…Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are…”
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Corrigendum to “The significance of recurrent de novo amino acid substitutions that emerged during chronic SARS-CoV-2 infection: an observational study” [eBioMedicine, 2024;107:105273] by Ip, Jonathan Daniel, Chu, Wing-Ming, Chan, Wan-Mui, Chu, Allen Wing-Ho, Leung, Rhoda Cheuk-Ying, Peng, Qi, Tam, Anthony Raymond, Chan, Brian Pui-Chun, Cai, Jian-Piao, Yuen, Kwok-Yung, Kok, Kin-Hang, Shi, Yi, Hung, Ivan Fan-Ngai, To, Kelvin Kai-Wang

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Risk Factors for Slow Viral Decline in COVID-19 Patients during the 2022 Omicron Wave by Li, Xin, Tam, Anthony Raymond, Chu, Wing-Ming, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Abdullah, Syed Muhammad Umer, Yip, Cyril Chik-Yan, Chan, Kwok-Hung, Wong, Samson Sai-Yin, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, To, Kelvin Kai-Wang

“…Formulating termination of isolation (de-isolation) policies requires up-to-date knowledge about viral shedding dynamics. However, current de-isolation…”
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Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics by Chan, Chris Chun-Yiu, Guo, Qian, Chan, Jasper Fuk-Woo, Tang, Kaiming, Cai, Jian-Piao, Chik, Kenn Ka-Heng, Huang, Yixin, Dai, Mei, Qin, Bo, Ong, Chon Phin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Wen, Lei, Tsang, Jessica Oi-Ling, Wang, Tong-Yun, Xie, Yubin, Qin, Zhenzhi, Cao, Jianli, Ye, Zi-Wei, Chu, Hin, To, Kelvin Kai-Wang, Ge, Xing-Yi, Ni, Tao, Jin, Dong-Yan, Cui, Sheng, Yuen, Kwok-Yung, Yuan, Shuofeng

“…There are only eight approved small molecule antiviral drugs for treating COVID-19. Among them, four are nucleotide analogues (remdesivir, JT001, molnupiravir,…”
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The first case of monkeypox in Hong Kong presenting as infectious mononucleosis-like syndrome by Chiu, Kelvin Hei-Yeung, Wong, Shuk-Ching, Tam, Anthony Raymond, Sridhar, Siddharth, Yip, Cyril Chik-Yan, Chan, Kwok-Hung, Chew, Nicholas Foo-Siong, Man, Kenyon Ka-Yun, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Lo, Janice Yee-Chi, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, To, Kelvin Kai-Wang, Cheng, Vincent Chi-Chung

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Rapid Diagnosis of Mycobacterium marinum Infection by Next-Generation Sequencing: A Case Report by Xing, Fanfan, Lo, Simon K F, Ma, Yuanchao, Ip, Jonathan Daniel, Chan, Wan-Mui, Zhou, Meixun, Gong, Miaozi, Lau, Susanna K P, Woo, Patrick C Y

“…We present the first report of histology- and culture-proven infection diagnosed by next-generation sequencing (NGS). It took <2 days to make a microbiological…”
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