Search Results - "Ip, Carman K. M."

Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow by Li, Shan-Shan, Ip, Carman K. M., Tang, Matthew Y. H., Tang, Maggie K. S., Tong, Yin, Zhang, Jiangwen, Hassan, Ayon Ahmed, Mak, Abby S. C., Yung, Susan, Chan, Tak-Mao, Ip, Philip P., Lee, Cheuk Lun, Chiu, Philip C. N., Lee, Leo Tsz On, Lai, Hung-Cheng, Zeng, Jin-Zhang, Shum, Ho Cheung, Wong, Alice S. T.

“…Organ-specific colonization suggests that specific cell–cell recognition is essential. Yet, very little is known about this particular interaction. Moreover,…”
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Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress by Ip, Carman K. M., Li, Shan-Shan, Tang, Matthew Y. H., Sy, Samuel K. H., Ren, Yong, Shum, Ho Cheung, Wong, Alice S. T.

“…One of greatest challenges to the successful treatment of cancer is drug resistance. An exciting approach is the eradication of cancer stem cells (CSCs)…”
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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies by Ip, Carman K. M., Ng, Patrick K. S., Jeong, Kang Jin, Shao, S. H., Ju, Zhenlin, Leonard, P. G., Hua, Xu, Vellano, Christopher P., Woessner, Richard, Sahni, Nidhi, Scott, Kenneth L., Mills, Gordon B.

“…Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this…”
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Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice by Li, Shan-Shan, Ip, Carman K M, Tang, Matthew Y H, Sy, Samuel K H, Yung, Susan, Chan, Tak-Mao, Yang, Mengsu, Shum, Ho Cheung, Wong, Alice S T

“…Ovarian cancer is characterized by extensive peritoneal metastasis, with tumor spheres commonly found in the malignant ascites. This is associated with poor…”
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Exploiting p70 S6 kinase as a target for ovarian cancer by Ip, Carman K M, Wong, Alice S T

“…The p70 S6 kinase (p70(S6K)) is frequently active in ovarian and a wide range of cancer types, and it has a crucial role in several processes considered…”
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Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells by Law, Alice Y.S., Lai, Keng P., Ip, Carman K.M., Wong, Alice S.T., Wagner, Graham F., Wong, Chris K.C.

“…Mammalian stanniocalcin-2 (STC2) is a secreted glycoprotein hormone with a putative role in unfolded protein response and apoptosis. Here we reported that STC2…”
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Data-driven discovery of innate immunomodulators via machine learning-guided high throughput screening by Tang, Yifeng, Kim, Jeremiah Y, Ip, Carman K M, Bahmani, Azadeh, Chen, Qing, Rosenberger, Matthew G, Esser-Kahn, Aaron P, Ferguson, Andrew L

“…The innate immune response is vital for the success of prophylactic vaccines and immunotherapies. Control of signaling in innate immune pathways can improve…”
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Environmental‐relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis by Lam, Sophia S. N., Shi, Zeyu, Ip, Carman K. M., Wong, Chris K. C., Wong, Alice S. T.

“…Abstract Bisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian…”
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Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK by Zhou, Hong Yan, Wan, Kai Fung, Ip, Carman K.M., Wong, Chris K.C., Mak, Nai Ki, Lo, Kwok Wai, Wong, Alice S.T.

“…The hepatocyte growth factor (HGF) receptor, Met, is frequently overexpressed in nasopharyngeal cancer (NPC). Here, we showed for the first time that human NPC…”
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Abstract GMM-059: SHEAR STRESS DOWNREGULATION OF MIR-199A-3P DRIVES CHEMORESISTANCE IN OVARIAN CANCER CELLS by Li, Shan-Shan, Ip, Carman K. M., Shum, Ho-Cheung, Wong, Alice S. T.

“…Abstract Ovarian cancer is leading cause of deaths among all gynecological malignancies. The presence of intrinsic and acquired drug resistance are major…”
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Abstract 5885: Sialyl Lewis X-P-selectin connection between ovarian tumor-mesothelium in early stage metastasis by Li, Shan-Shan, Ip, Carman K. M., Hassan, Ayon A., Tang, Matthew Y. H., Yung, Susan, Chan, Tak-Mao, Shum, Ho Cheung, Wong, Alice S. T.

“…Abstract Metastasis is one of the major challenges for the treatment of ovarian cancer. Unlike other solid tumors, ovarian cancer primarily disseminates within…”
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Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice by Li, Shan-Shan, Ip, Carman K. M., Tang, Matthew Y. H., Sy, Samuel K. H., Yung, Susan, Chan, Tak-Mao, Yang, Mengsu, Shum, Ho Cheung, Wong, Alice S.T.

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Sialyl Lewis x -P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow by Li, Shan-Shan, Ip, Carman K M, Tang, Matthew Y H, Tang, Maggie K S, Tong, Yin, Zhang, Jiangwen, Hassan, Ayon Ahmed, Mak, Abby S C, Yung, Susan, Chan, Tak-Mao, Ip, Philip P, Lee, Cheuk Lun, Chiu, Philip C N, Lee, Leo Tsz On, Lai, Hung-Cheng, Zeng, Jin-Zhang, Shum, Ho Cheung, Wong, Alice S T

“…Organ-specific colonization suggests that specific cell-cell recognition is essential. Yet, very little is known about this particular interaction. Moreover,…”
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Data-driven discovery of innate immunomodulators machine learning-guided high throughput screening by Tang, Yifeng, Kim, Jeremiah Y, IP, Carman K. M, Bahmani, Azadeh, Chen, Qing, Rosenberger, Matthew G, Esser-Kahn, Aaron P, Ferguson, Andrew L

“…The innate immune response is vital for the success of prophylactic vaccines and immunotherapies. Control of signaling in innate immune pathways can improve…”
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Genomic-Glycosylation Aberrations in Tumor Initiation, Progression and Management by K.M. Ip, Carman, Yin, Jun, K.S. Ng, Patrick, Lin, Shiaw-Yih, B. Mills, Gordon

“…Post-translation modifications of proteins alter their functional activity and thus are key contributors of tumor initiation and progression. Glycosylation,…”
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p70 S6 kinase and actin dynamics: A perspective by Ip, Carman K.M., Wong, Alice S.T.

“…p70 S6 kinase (p70 S6K ), a member of the AGC serine/threonine kinase family, was initially identified as a key player, together with its downstream effector…”
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Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs by Kim, Jeremiah Y., Rosenberger, Matthew G., Chen, Siquan, IP, Carman KM, Bahmani, Azadeh, Chen, Qing, Shen, Jinjing, Tang, Yifeng, Wang, Andrew, Kenna, Emma, Son, Minjun, Tay, Savaş, Ferguson, Andrew L., Esser-Kahn, Aaron P.

“…Stimulation of the innate immune system is crucial in both effective vaccinations and immunotherapies. This is often achieved through adjuvants, molecules that…”
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