Search Results - "Ip, Blanche C."

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis by Nicholas, Dequina, Proctor, Elizabeth A, Raval, Forum M, Ip, Blanche C, Habib, Chloe, Ritou, Eleni, Grammatopoulos, Tom N, Steenkamp, Devin, Dooms, Hans, Apovian, Caroline M, Lauffenburger, Douglas A, Nikolajczyk, Barbara S

“…Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may…”
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Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure by Fonseca, Vera C., Van, Vivian, Ip, Blanche C.

“…Purpose Human extracellular matrix (ECM) exhibits complex protein composition and architecture depending on tissue and disease state, which remains challenging…”
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Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice by Ip, Blanche C, Liu, Chun, Ausman, Lynne M, von Lintig, Johannes, Wang, Xiang-Dong

“…Obesity is associated with increased liver cancer risks and mortality. We recently showed that apo-10'-lycopenoic acid, a lycopene metabolite generated by…”
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Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip, Blanche C, Wang, Xiang-Dong

“…Increased prevalence of non-alcoholic fatty liver disease (NAFLD) is one of the consequences of the current obesity epidemic. NAFLD is a major form of chronic…”
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Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice by Li, Xinli, Liu, Chun, Ip, Blanche C, Hu, Kang-Quan, Smith, Donald E, Greenberg, Andrew S, Wang, Xiang-Dong

“…Tumor progression locus 2 (TPL2), a serine-threonine kinase, functions as a critical regulator of inflammatory pathways and mediates oncogenic events. The…”
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Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice by IP, Blanche C, HU, Kang-Quan, CHUN LIU, SMITH, Donald E, OBIN, Martin S, AUSMAN, Lynne M, WANG, Xiang-Dong

“…Obesity is associated with increased risk in hepatocellular carcinoma (HCC) development and mortality. An important disease control strategy is the prevention…”
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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes by Nicholas, Dequina A., Proctor, Elizabeth A., Agrawal, Madhur, Belkina, Anna C., Van Nostrand, Stephen C., Panneerseelan-Bharath, Leena, Jones, Albert R., Raval, Forum, Ip, Blanche C., Zhu, Min, Cacicedo, Jose M., Habib, Chloe, Sainz-Rueda, Nestor, Persky, Leah, Sullivan, Patrick G., Corkey, Barbara E., Apovian, Caroline M., Kern, Philip A., Lauffenburger, Douglas A., Nikolajczyk, Barbara S.

“…Mechanisms that regulate metabolites and downstream energy generation are key determinants of T cell cytokine production, but the processes underlying the Th17…”
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3D Microtissues Mimic the Architecture, Estradiol Synthesis, and Gap Junction Intercellular Communication of the Avascular Granulosa by Ip, Blanche C, Leary, Elizabeth, Knorlein, Benjamin, Reich, David, Van, Vivian, Manning, Joshua, Morgan, Jeffrey R

“…Abstract Humans are consistently exposed to thousands of untested chemicals that have been detected in the follicular fluid of the ovaries, and can disrupt…”
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Lymphocyte roles in metabolic dysfunction: of men and mice by Ip, Blanche C, Hogan, Andrew E, Nikolajczyk, Barbara S

“…Highlights • Lymphocytes have complex regulatory roles in obesity-associated insulin resistance and type 2 diabetes pathogenesis. • Obesity differentially…”
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Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice by Ip, Blanche C, Liu, Chun, Lichtenstein, Alice H, von Lintig, Johannes, Wang, Xiang-Dong

“…Nonalcoholic fatty liver disease is positively associated with obesity and cardiovascular disease risk. Apo-10'-lycopenoic acid (APO10LA), a potential…”
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The bio-gripper: a fluid-driven micro-manipulator of living tissue constructs for additive bio-manufacturing by Ip, Blanche C, Cui, Francis, Tripathi, Anubhav, Morgan, Jeffrey R

“…We previously developed the Bio-Pick, Place, and Perfuse (Bio-P3) instrument to fabricate large perfusable tissue constructs by stacking and aligning…”
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Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels by Khoo, Amanda S, Valentin, Thomas M, Leggett, Susan E, Bhaskar, Dhananjay, Bye, Elisa M, Benmelech, Shoham, Ip, Blanche C, Wong, Ian Y

“…Invading cancer cells adapt their migration phenotype in response to mechanical and biochemical cues from the extracellular matrix. For instance, mesenchymal…”
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Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats by Nascimento, André F., Ip, Blanche C., Luvizotto, Renata A. M., Seitz, Helmut K., Wang, Xiang-Dong

“…Chronic alcohol intake decreases adiponectin and sirtuin 1 (SIRT1) expressions, both of which have been implicated in various biological processes including…”
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Does fetal leptin and adiponectin influence children's lung function and risk of wheeze? by Ip, Blanche C, Li, Nan, Jackson-Browne, Medina, Eliot, Melissa, Xu, Yingying, Chen, Aimin, Lanphear, Bruce P, Spanier, Adam J, Braun, Joseph M

“…Adipocytokines, which are secreted during fetal development by both mothers and fetuses, may influence fetal lung development, but little human data are…”
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Hydrodynamics of the Bio-Gripper: A Fluid-Driven "Claw Machine" for Soft Microtissue Translocation by Cui, Francis R, Ip, Blanche C, Morgan, Jeffrey R, Tripathi, Anubhav

“…Technological advances in solid organ tissue engineering that rely on the assembly of small tissue-building parts require a novel transport method suited for…”
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High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice by Ip, Blanche C, Liu, Chun, Smith, Donald E, Ausman, Lynne M, Wang, Xiang-Dong

“…Previous studies demonstrated that diet-induced obese mice fed a semi-purified high-fat diet (HFD) had greater liver tumorigenesis than mice fed a…”
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Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging by Bharath, Leena P, Ip, Blanche C, Nikolajczyk, Barbara S

“…Adipose tissue (AT) is the primary energy reservoir organ, and thereby plays a critical role in energy homeostasis and regulation of metabolism. AT expands in…”
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Perfused Organ Cell‐Dense Macrotissues Assembled from Prefabricated Living Microtissues by Ip, Blanche C., Cui, Francis, Wilks, Benjamin T., Murphy, John, Tripathi, Anubhav, Morgan, Jeffrey R.

“…Engineered tissues usually fall short of physiological cell densities and sizes, resulting in limited functional performance. Viability of large tissues is…”
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Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment by Ip, Blanche C, Madnick, Samantha J, Zheng, Sophia, van Tongeren, Tessa C A, Hall, Susan J, Li, Hui, Martin, Suzanne, Spriggs, Sandrine, Carmichael, Paul, Chen, Wei, Ames, David, Breitweiser, Lori A, Pence, Heather E, Bowling, Andrew J, Johnson, Kamin J, Cubberley, Richard, Morgan, Jeffrey R, Boekelheide, Kim

“…Chemicals in the systemic circulation can undergo hepatic xenobiotic metabolism, generate metabolites, and exhibit altered toxicity compared with their parent…”
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Abstract 4724: Optimizing 500 pooled PRISM cell lines for a 10-day assay to elucidate viability effects and mechanism of action for slower-acting therapeutics by Ronan, Melissa, Ip, Blanche C., Nguyen, Ellen, Widocki, Ursula, Sangpo, Tenzin, Kalathungal, Alvin, Diaz-Gallegos, Nashielli, Fazio, Anthony, Golabi, Aydin, Naim, Maha, George, Ashish Bino, Liu, YuhJong, Kocak, Mustafa, Puram, Rishi, Rees, Matthew G., Roth, Jennifer

“…PRISM (Profiling Relative Inhibition Simultaneously in Mixtures), using DNA-barcoded cell lines cultured as ~25 cell line pools, has been an effective drug…”
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