Search Results - "Iovanna, J"

A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma by Nicolle, R., Gayet, O., Duconseil, P., Vanbrugghe, C., Roques, J., Bigonnet, M., Blum, Y., Elarouci, N., Armenoult, L., Ayadi, M., de Reyniès, A., Puleo, F., Augustin, J., Emile, J.F., Svrcek, M., Arsenijevic, T., Hammel, P., Giovannini, M., Grandval, P., Dahan, L., Moutardier, V., Gilabert, M., Van Laethem, J.L., Bachet, J.B., Cros, J., Iovanna, J., Dusetti, N.J.

“…Chemotherapy is the only systemic treatment approved for pancreatic ductal adenocarcinoma (PDAC), with a selection of regimens based on patients' performance…”
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Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E by Andrieu, C, Taieb, D, Baylot, V, Ettinger, S, Soubeyran, P, De-Thonel, A, Nelson, C, Garrido, C, So, A, Fazli, L, Bladou, F, Gleave, M, Iovanna, J L, Rocchi, P

“…One strategy to improve therapies in advanced prostate cancer (PC) involves targeting genes that are activated by androgen withdrawal to delay the emergence of…”
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A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation by Radulovic, K, Normand, S, Rehman, A, Delanoye-Crespin, A, Chatagnon, J, Delacre, M, Waldschmitt, N, Poulin, L F, Iovanna, J, Ryffel, B, Rosenstiel, P, Chamaillard, M

“…Flavones represent a class of polyphenols that are found in many plant-derived food sources. Herein, we provide evidence that the anti-inflammatory and…”
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Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation by Peuget, S, Bonacci, T, Soubeyran, P, Iovanna, J, Dusetti, N J

“…Tumor Protein p53-Induced Nuclear Protein 1 (TP53INP1) is a tumor suppressor that modulates the p53 response to stress. TP53INP1 is one of the key mediators of…”
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NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance by Emma, M R, Iovanna, J L, Bachvarov, D, Puleio, R, Loria, G R, Augello, G, Candido, S, Libra, M, Gulino, A, Cancila, V, McCubrey, J A, Montalto, G, Cervello, M

“…Sorafenib, an oral multikinase inhibitor, is the only approved agent for the treatment of advanced hepatocellular carcinoma (HCC). However, its benefits are…”
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TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death by Seillier, M, Peuget, S, Gayet, O, Gauthier, C, N'Guessan, P, Monte, M, Carrier, A, Iovanna, J L, Dusetti, N J

“…TP53INP1 (tumor protein 53-induced nuclear protein 1) is a tumor suppressor, whose expression is downregulated in cancers from different organs. It was…”
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The xenobiotic transporter ABCC4 /MRP4 promotes epithelial mesenchymal transition in pancreatic cancer by Gancedo, S N, Sahores, A, Gómez, N, Di Siervi, N, May, M, Yaneff, A, de Sousa Serro, M G, Fraunhoffer, N, Dusetti, N, Iovanna, J, Shayo, C, Davio, C A, González, B

“…The xenobiotic transporter /MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic…”
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Development and validation of AI-assisted transcriptomic signatures to personalize adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma by Fraunhoffer, N, Hammel, P, Conroy, T, Nicolle, R, Bachet, J-B, Harlé, A, Rebours, V, Turpin, A, Ben Abdelghani, M, Mitry, E, Biagi, J, Chanez, B, Bigonnet, M, Lopez, A, Evesque, L, Lecomte, T, Assenat, E, Bouché, O, Renouf, D J, Lambert, A, Monard, L, Mauduit, M, Cros, J, Iovanna, J, Dusetti, N

“…After surgical resection of pancreatic ductal adenocarcinoma (PDAC), patients are predominantly treated with adjuvant chemotherapy, commonly consisting of…”
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IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice by Moyat, M, Bouzourene, H, Ouyang, W, Iovanna, J, Renauld, J-C, Velin, D

“…Despite the recent description of the mucosal vaccine-induced reduction of Helicobacter pylori natural infection in a phase 3 clinical trial, the absence of…”
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TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma by Thakur, A K, Nigri, J, Lac, S, Leca, J, Bressy, C, Berthezene, P, Bartholin, L, Chan, P, Calvo, E, Iovanna, J L, Vasseur, S, Guillaumond, F, Tomasini, R

“…Advances made in pancreatic cancer therapy have been far from sufficient and have allowed only a slight improvement in global survival of patients with…”
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OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer by Baylot, V, Andrieu, C, Katsogiannou, M, Taieb, D, Garcia, S, Giusiano, S, Acunzo, J, Iovanna, J, Gleave, M, Garrido, C, Rocchi, P

“…Despite many advances in oncology, almost all patients with pancreatic cancer (PC) die of the disease. Molecularly targeted agents are offering hope for their…”
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Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence by Grasso, D, Garcia, M N, Hamidi, T, Cano, C, Calvo, E, Lomberk, G, Urrutia, R, Iovanna, J L

“…Nuclear protein 1 (Nupr1), a small chromatin protein, has a critical role in cancer development, progression and resistance to therapy. Previously, we had…”
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Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer by Nicolle, R., Gayet, O., Bigonnet, M., Roques, J., Chanez, B., Puleo, F., Augustin, J., Emile, J.F., Svrcek, M., Arsenijevic, T., Hammel, P., Rebours, V., Giovannini, M., Grandval, P., Dahan, L., Moutardier, V., Mitry, E., Van Laethem, J.L., Bachet, J.B., Cros, J., Iovanna, J., Dusetti, N.J.

“…•Most patient with pancreatic cancer are treated by chemotherapy.•Treatments selection are not personalized on the tumor characteristics.•Signatures predicting…”
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EpiShift: A new paradigm in chemosensitivity modulation in PDAC through epigenetics by Fraunhoffer, N., Meilerman Abuelafia, A., Rémy, N., Gayet, O., Dusetti, N., Iovanna, J.

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Inducing ferroptosis by the NUPR1 inhibitor ZZW115 to kill pancreatic cancer cells by Huang, C., Santofimia-Castaño, P., Lan, W., Fraunhoffer, N., Meilerman, A., Iovanna, J.

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RNA-based personalized nanomedicine for treating pancreatic cancer by Lan, W., Tang, J., Jiang, Y., Patricia, S., Dussetti, N., Iovanna, J., Peng, L.

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Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation by Salazar, M, Lorente, M, García-Taboada, E, Pérez Gómez, E, Dávila, D, Zúñiga-García, P, María Flores, J, Rodríguez, A, Hegedus, Z, Mosén-Ansorena, D, Aransay, A M, Hernández-Tiedra, S, López-Valero, I, Quintanilla, M, Sánchez, C, Iovanna, J L, Dusetti, N, Guzmán, M, Francis, S E, Carracedo, A, Kiss-Toth, E, Velasco, G

“…Tribbles pseudokinase-3 (TRIB3) has been proposed to act as an inhibitor of AKT although the precise molecular basis of this activity and whether the loss of…”
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TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression by Seux, M, Peuget, S, Montero, M P, Siret, C, Rigot, V, Clerc, P, Gigoux, V, Pellegrino, E, Pouyet, L, N'Guessan, P, Garcia, S, Dufresne, M, Iovanna, J L, Carrier, A, André, F, Dusetti, N J

“…Tumor protein 53 induced nuclear protein 1 (TP53INP1) is a p53 target gene that induces cell growth arrest and apoptosis by modulating p53 transcriptional…”
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Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling by Secq, V, Leca, J, Bressy, C, Guillaumond, F, Skrobuk, P, Nigri, J, Lac, S, Lavaut, M-N, Bui, T-t, Thakur, A K, Callizot, N, Steinschneider, R, Berthezene, P, Dusetti, N, Ouaissi, M, Moutardier, V, Calvo, E, Bousquet, C, Garcia, S, Bidaut, G, Vasseur, S, Iovanna, J L, Tomasini, R

“…Pancreatic ductal adenocarcinoma (PDA) is a critical health issue in the field of cancer, with few therapeutic options. Evidence supports an implication of the…”
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VAV2 regulates epidermal growth factor receptor endocytosis and degradation by Thalappilly, S, Soubeyran, P, Iovanna, J L, Dusetti, N J

“…Vav proteins are guanine nucleotide exchange factors for Rho GTPases that regulate cell adhesion, motility, spreading and proliferation in response to growth…”
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