Search Results - "Iorgulescu, J Bryan"

Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy by Gohil, Satyen H., Iorgulescu, J. Bryan, Braun, David A., Keskin, Derin B., Livak, Kenneth J.

“…Advances in molecular biology, microfluidics and bioinformatics have empowered the study of thousands or even millions of individual cells from malignant…”
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Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma by Hu, Zhuting, Leet, Donna E., Allesøe, Rosa L., Oliveira, Giacomo, Li, Shuqiang, Luoma, Adrienne M., Liu, Jinyan, Forman, Juliet, Huang, Teddy, Iorgulescu, J. Bryan, Holden, Rebecca, Sarkizova, Siranush, Gohil, Satyen H., Redd, Robert A., Sun, Jing, Elagina, Liudmila, Giobbie-Hurder, Anita, Zhang, Wandi, Peter, Lauren, Ciantra, Zoe, Rodig, Scott, Olive, Oriol, Shetty, Keerthi, Pyrdol, Jason, Uduman, Mohamed, Lee, Patrick C., Bachireddy, Pavan, Buchbinder, Elizabeth I., Yoon, Charles H., Neuberg, Donna, Pentelute, Bradley L., Hacohen, Nir, Livak, Kenneth J., Shukla, Sachet A., Olsen, Lars Rønn, Barouch, Dan H., Wucherpfennig, Kai W., Fritsch, Edward F., Keskin, Derin B., Wu, Catherine J., Ott, Patrick A.

“…Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term…”
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Acquired mechanisms of immune escape in cancer following immunotherapy by Iorgulescu, J Bryan, Braun, David, Oliveira, Giacomo, Keskin, Derin B, Wu, Catherine J

“…Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of…”
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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma by Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

“…Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data…”
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Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery by Ivan, Michael E, Bryan Iorgulescu, J, El-Sayed, Ivan, McDermott, Michael W, Parsa, Andrew T, Pletcher, Steven D, Jahangiri, Arman, Wagner, Jeffrey, Aghi, Manish K

“…Abstract Postoperative cerebrospinal fluid (CSF) leak is a serious complication of transsphenoidal surgery, which can lead to meningitis and often requires…”
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The epidemiology of primary and metastatic brain tumors in infancy through childhood by Lamba, Nayan, Groves, Andrew, Torre, Matthew, Yeo, Kee Kiat, Iorgulescu, J. Bryan

“…Purpose To evaluate the epidemiology of primary and metastatic pediatric brain tumors in the United States according to the WHO CNS 4th and 5th editions…”
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Contemporary assessment of extent of resection in molecularly defined categories of diffuse low-grade glioma: a volumetric analysis by Kavouridis, Vasileios K, Boaro, Alessandro, Dorr, Jeffrey, Cho, Elise Y, Iorgulescu, J Bryan, Reardon, David A, Arnaout, Omar, Smith, Timothy R

“…While the effect of increased extent of resection (EOR) on survival in diffuse infiltrating low-grade glioma (LGG) patients is well established, there is still…”
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Local disease control for spinal metastases following "separation surgery" and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients by Laufer, Ilya, Iorgulescu, J Bryan, Chapman, Talia, Lis, Eric, Shi, Weiji, Zhang, Zhigang, Cox, Brett W, Yamada, Yoshiya, Bilsky, Mark H

“…Decompression surgery followed by adjuvant radiotherapy is an effective therapy for preservation or recovery of neurological function and achieving durable…”
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Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity by Backlund, Coralie M., Holden, Rebecca L., Moynihan, Kelly D., Garafola, Daniel, Farquhar, Charlotte, Mehta, Naveen K., Maiorino, Laura, Pham, Sydney, Iorgulescu, J. Bryan, Reardon, David A., Wu, Catherine J., Pentelute, Bradley L., Irvine, Darrell J.

“…Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide…”
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Epidemiology of common and uncommon adult pituitary tumors in the U.S. according to the 2017 World Health Organization classification by Castellanos, Luz E., Gutierrez, Catherine, Smith, Timothy, Laws, Edward R., Iorgulescu, J. Bryan

“…Purpose To examine the contemporary epidemiology of adult pituitary tumors with a particular focus on uncommon tumor types, using the 2017 WHO Classification…”
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Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma by Lim-Fat, Mary Jane, Song, Kun Wei, Iorgulescu, J. Bryan, Andersen, Brian M., Forst, Deborah A., Jordan, Justin T., Gerstner, Elizabeth R., Reardon, David A., Wen, Patrick Y., Arrillaga-Romany, Isabel

“…Purpose Although uncommon, detection of BRAF V600E mutations in adult patients with glioblastoma has become increasingly relevant given the widespread…”
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The impact of the COVID-19 pandemic on treatment patterns in glioblastoma by Neff, Corey, Price, Mackenzie, Cioffi, Gino, Waite, Kristin A, Kruchko, Carol, Iorgulescu, J Bryan, Barnholtz-Sloan, Jill S, Ostrom, Quinn T

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Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models by Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth M, Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy X, Naxerova, Kamila, Kumar, Ashwin S, Ghosh, Mitrajit, Emblem, Kyrre E, Ng, Mei R, Ho, William W, Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria C, Neagu, Martha R, Iorgulescu, J Bryan, Huang, Raymond Y, Youssef, Gilbert, Reardon, David A, Sharpe, Arlene H, Freeman, Gordon J, Suvà, Mario L, Xu, Lei, Jain, Rakesh K

“…Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice…”
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Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial by Xu, Ran, Shimizu, Fumiko, Hovinga, Koos, Beal, Kathryn, Karimi, Sasan, Droms, Leif, Peck, Kyung K, Gutin, Philip, Iorgulescu, J Bryan, Kaley, Thomas, DeAngelis, Lisa, Pentsova, Elena, Nolan, Craig, Grommes, Christian, Chan, Timothy, Bobrow, Dylan, Hormigo, Adilia, Cross, Justin R, Wu, Nian, Takebe, Naoko, Panageas, Katherine, Ivy, Percy, Supko, Jeffrey G, Tabar, Viviane, Omuro, Antonio

“…High-grade gliomas are associated with a dismal prognosis. Notch inhibition via the gamma-secretase inhibitor RO4929097 has emerged as a potential therapeutic…”
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Spindle cell oncocytoma of the pituitary gland by Giantini Larsen, Alexandra M, Cote, David J, Zaidi, Hasan A, Bi, Wenya Linda, Schmitt, Paul J, Iorgulescu, J Bryan, Miller, Michael B, Smith, Timothy R, Lopes, M Beatriz, Jane, John A, Laws, Edward R

“…The authors report the diagnosis, management, and outcomes of 6 cases of spindle cell oncocytoma (SCO) in an effort to guide clinical diagnosis and management…”
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The epidemiology and management patterns of pediatric pituitary tumors in the United States by Castellanos, Luz E., Misra, Madhusmita, Smith, Timothy R., Laws, Edward R., Iorgulescu, J. Bryan

“…Purpose Hypothalamic-pituitary axis dysfunction and mass effect symptoms in the pediatric population can indicate a pituitary region tumor. Herein, we evaluate…”
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Improved outcomes associated with maximal extent of resection for butterfly glioblastoma: insights from institutional and national data by Boaro, Alessandro, Kavouridis, Vasileios K., Siddi, Francesca, Mezzalira, Elisabetta, Harary, Maya, Iorgulescu, J. Bryan, Reardon, David A., Smith, Timothy R.

“…Background Butterfly glioblastomas (bGBMs) are grade IV gliomas that infiltrate the corpus callosum and spread to bilateral cerebral hemispheres. Due to the…”
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The incidence and patterns of hardware failure after separation surgery in patients with spinal metastatic tumors by Amankulor, Nduka M., MD, Xu, Ran, MD, Iorgulescu, J. Bryan, BS, Chapman, Talia, BS, Reiner, Anne S., MPH, Riedel, Elyn, MA, Lis, Eric, MD, Yamada, Yoshiya, MD, Bilsky, Mark, MD, Laufer, Ilya, MD

“…Abstract Background context Spine metastases occur frequently in patients with cancer. A variety of surgical approaches, including anterior transcavitary,…”
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Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding by Siu, Alan, Wind, Joshua J., Iorgulescu, J. Bryan, Chan, Timothy A., Yamada, Yoshiya, Sherman, Jonathan H.

“…Radiation therapy is an integral part of the standard treatment paradigm for malignant gliomas, with proven efficacy in randomized control trials. Radiation…”
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Endoscopic endonasal resection of skull base chondrosarcomas: technique and early results by Moussazadeh, Nelson, Kulwin, Charles, Anand, Vijay K, Ting, Jonathan Y, Gamss, Caryn, Iorgulescu, J Bryan, Tsiouris, Apostolos John, Cohen-Gadol, Aaron A, Schwartz, Theodore H

“…The authors of this study sought to report the technique and early clinical outcomes of a purely endonasal endoscopic approach for resection of petroclival…”
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